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Neuropeptide Y-Containing Neurons are Situated Predominantly Outside Cytochrome Oxidase Puffs in Macaque Visual Cortex

Published online by Cambridge University Press:  02 June 2009

Rodrigo O. Kuljis  and
Pasko Rakic
Rodrigo O. Kuljis
Affiliation:
Section of Neuroanatomy, Yale University School of Medicine, New Haven
Pasko Rakic
Affiliation:
Section of Neuroanatomy, Yale University School of Medicine, New Haven
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Abstract

Layers II/III of the primary visual cortex contain a regular pattern of histochemically detectable cytochrome oxidase (CO)-rich “puffs,” which differ from the interpuff regions in their thalamo-cortical and cortico-cortical connectivity, receptive-field properties, and the density of inhibitory GABA-containing synaptic terminals. We used an immunocytochemical method, in combination with cytochrome oxidase histochemistry, to analyze the spatial relationship between neurons that contain neuropeptide Y (NPY) and the CO puffs. Of a total of 606 neurons, only 2.6% of the NPY-containing cells are located in the puffs, whereas the rest are situated in the interpuffs, or at the interface between puffs and interpuffs. The number of NPY-containing neurons in the puffs is substantially less than that expected in an equal volume of the interpuffs (X2 = 13.86; df = 1; P < 0.001).

These observations indicate that columns containing the puffs may differ also from those in the interpuff regions in that they contain a unique array of chemically and morphologically distinct local circuit neurons.

Keywords

Neuropeptide YCytochrome oxidaseStriate cortexMacaque monkeyLocal circuit neurons
Type
Research Articles
Information
Visual Neuroscience , Volume 2 , Issue 1 , January 1989 , pp. 57 - 62
Copyright
Copyright © Cambridge University Press 1989

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