Hostname: page-component-76fb5796d-zzh7m Total loading time: 0 Render date: 2024-04-26T07:17:32.129Z Has data issue: false hasContentIssue false
  • English
  • Français

Parvalbumin immunoreactivity in the lateral geniculate nucleus of rhesus monkeys raised under monocular and binocular deprivation conditions

Published online by Cambridge University Press:  02 June 2009

Margarete Tigges  and
Johannes Tigges
Margarete Tigges
Affiliation:
Yerkes Regional Primate Research Center, and Departments of Anatomy and Cell Biology, and Ophthalmology, Emory University, Atlanta
Johannes Tigges
Affiliation:
Yerkes Regional Primate Research Center, and Departments of Anatomy and Cell Biology, and Ophthalmology, Emory University, Atlanta
Get access Rights & Permissions [Opens in a new window]

Abstract

Newborn rhesus monkeys were raised under monocular (lid suture, aphakia, aphakia corrected optically with contact lenses, and occlusion with opaque occluder lenses) and under binocular visual deprivation conditions (aphakia combined with occlusion or optical undercorrection of the fellow eye). Routine immunohistochemical methods with an antibody to the calcium-binding protein parvalbumin (PV) were used to examine the distribution of PV+ neurons and PV+ processes in the LGN of these monkeys. Under all rearing conditions, we found no obvious difference in PV density in neurons in any lamina, although in all monocularly deprived and in two of the three binocularly deprived monkeys neurons connected to the deprived eye were of reduced size. Furthermore, PV-immunoreactive processes in the neuropil of deprived laminae were as numerous and of the same morphologies as those in nondeprived laminae or as in normal controls. Thus, in the LGN of rhesus monkeys, the calcium-binding protein parvalbumin is resistant to monocular as well as binocular visual deprivation during the postnatal maturation process of the visual system.

Keywords

ParvalbuminImmunocytochemistryResistance to visual deprivation
Type
Research Articles
Information
Visual Neuroscience , Volume 10 , Issue 6 , November 1993 , pp. 1043 - 1053
Copyright
Copyright © Cambridge University Press 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Baimbridge, K.G., Celio, M.R. & Rogers, J.H. (1992). Calcium-binding proteins in the nervous system. Trends in Neurosciences 15, 303–308.CrossRefGoogle ScholarPubMed
Blakemore, C. & Vital-Durand, F. (1986). Effects of visual deprivation on the development of the monkey’s lateral geniculate nucleus. Journal of Physiology 380, 493–511.CrossRefGoogle ScholarPubMed
Demeulemeester, H., Vandesande, F., Orban, G.A., Heizmann, C.W. & Pochet, R. (1989). Calbindin D-28K and parvalbumin immunoreactivity is confined to two separate neuronal subpopulations in the cat visual cortex, whereas partial coexistence is shown in the dorsal lateral geniculate nucleus. Neuroscience Letters 99, 6–11.CrossRefGoogle ScholarPubMed
Fernandes, A., Tigges, M., Tigges, J., Gammon, J.A. & Chandler, C. (1988). Management of extended-wear contact lenses in infant rhesus monkeys. Behavior Research Methods, Instruments, and Computers 20, 11–17.CrossRefGoogle Scholar
Gammon, J.A., Boothe, R.G., Chandler, C.V., Tigges, M. & Wilson, J.R. (1985). Extended-wear soft contact lenses for vision studies in monkeys. Investigative Ophthalmology and Visual Science 26, 1636–1639.Google ScholarPubMed
Golladay, G.J., Butler, G.D., Tigges, M. & Mize, R.R. (1993). Monocular enucleation reduces GABA immunoreactivity in the lateral geniculate nucleus (LGN) of the rhesus monkey. Investigative Ophthalmology and Visual Science 34, 1172.Google Scholar
Harwerth, R.S., Smith, E.L. III, Crawford, M.L.J. & Von Noor-Den, G.K. (1990). Behavioral studies of the sensitive periods of development of visual functions in monkeys. Behavioral Brain Research 41, 179–198.CrossRefGoogle ScholarPubMed
Heizmann, C.W. & Braun, K. (1992). Changes in Ca2+-binding proteins in human neurodegenerative disorders. Trends in Neurosciences 15, 259–264.CrossRefGoogle Scholar
Hendrickson, A.E., Movshon, J.A., Eggers, H.M., Gizzi, M.S., Boothe, R.G. & Kiorpes, L. (1987). Effects of early unilateral blur on the macaque's visual system. II. Anatomical observations. Journal of Neuroscience 7, 1327–1339.CrossRefGoogle ScholarPubMed
Hendry, S.H.C. (1991). Delayed reduction in GABA and GAD immunoreactivity of neurons in the adult monkey dorsal lateral geniculate nucleus following monocular deprivation or enucleation. Experimental Brain Research 86, 47–59.CrossRefGoogle ScholarPubMed
Iuvone, P.M., Tigges, M., Fernandes, A. & Tigges, J. (1989). Dopamine synthesis and metabolism in rhesus monkey retina: Development, aging, and the effects of monocular visual deprivation. Visual Neuroscience 2, 465–471.CrossRefGoogle ScholarPubMed
Iuvone, P.M., Tigges, M., Stone, R.A., Lambert, S. & Laties, A.M. (1991). Effects of apomorphine, a dopamine receptor agonist, on ocular refraction and axial elongation in a primate model of myopia. Investigative Ophthalmology and Visual Science 32, 1674–1677.Google Scholar
Jones, E.G. & Hendry, S.H.C. (1989). Differential calcium-binding protein immunoreactivity distinguishes classes of relay neurons in monkey thalamic nuclei. European Journal of Neuroscience 1, 222–246.CrossRefGoogle ScholarPubMed
Lynch, J.J. III, Silveira, L.C.L., Perry, V.H. & Merigan, W.H. (1992). Visual effects of damage to P ganglion cells in macaques. Visual Neuroscience 8, 575–583.CrossRefGoogle Scholar
Mastronarde, D.N. (1989). Correlated firing of retinal ganglion cells. Trends in Neurosciences 12, 75–80.CrossRefGoogle ScholarPubMed
Meister, M., Wong, R.O.L., Baylor, D.A. & Shatz, C.J. (1991). Synchronous bursts of action potentials in ganglion cells of the developing mammalian retina. Science 252, 939–943.CrossRefGoogle ScholarPubMed
Mize, R.R. & Luo, Q. (1992). Visual deprivation fails to reduce calbindin 28 kD or GABA immunoreactivity in the Rhesus monkey superior colliculus. Visual Neuroscience 9, 157–168.CrossRefGoogle ScholarPubMed
Mize, R.R., Luo, Q. & Tigges, M. (1992). Monocular enucleation reduces immunoreactivity to the calcium-binding protein calbindin 28 kD in the Rhesus monkey lateral geniculate nucleus. Visual Neuroscience 9, 471–482.CrossRefGoogle Scholar
Omidi, K., Hendry, S.H.C, Jones, E.G. & Emson, P.C. (1988). Organization and plasticity of GABA neuronal subpopulations in monkey area 17, identified by coexistence of calcium-binding proteins. Society for Neuroscience Abstracts 14, 188.Google Scholar
Peters, A. & Sethares, C. (1991). Layer IVA of rhesus monkey primary visual cortex. Cerebral Cortex 1, 445–462.CrossRefGoogle ScholarPubMed
Rausell, E., Cusick, C.G., Taub, E. & Jones, E.G. (1992). Chronic deafferentation in monkeys differentially affects nociceptive and nonnociceptive pathways distinguished by specific calcium-binding proteins and down-regulates γ-aminobutyric acid type A receptors at thalamic levels. Proceedings of the National Academy of Sciences of the U.S.A. 89, 2571–2575.CrossRefGoogle ScholarPubMed
Stichel, C.C., Singer, W. & Heizmann, C.W. (1988). Light- and electron-microscopic immunocytochemical localization of parvalbumin in the dorsal lateral geniculate nucleus of the cat: Evidence for coexistence with GABA. Journal of Comparative Neurology 268, 29–37.CrossRefGoogle ScholarPubMed
Tigges, M. & Tigges, J. (1991). Parvalbumin of the lateral geniculate nucleus in adult rhesus monkeys after monocular eye enucleation. Visual Neuroscience 6, 375–382.CrossRefGoogle ScholarPubMed
Tigges, M., Boothe, R.G., Tigges, J. & Wilson, J.R. (1992 a). Competition between an aphakic and an occluded eye for territory in striate cortex of developing rhesus monkeys: Cytochrome oxidase histochemistry in layer 4C. Journal of Comparative Neurology 316, 173–186.CrossRefGoogle Scholar
Tigges, M., Tigges, J., Boothe, R.G. & Wilson, J.R. (1992 b). Parvalbumin immunoreactivity (PVi) in the lateral geniculate nucleus (LGN) of developing macaque monkeys after monocular visual deprivation. Investigative Ophthalmology and Visual Science (Suppl.) 33, 1215.Google Scholar
Von Noorden, G.K. (1973). Histological studies of the visual system in monkeys with experimental amblyopia. Investigative Ophthalmology 12, 727–738.Google ScholarPubMed
Von Noorden, G.K. & Crawford, M.L.J. (1977). Form deprivation without light deprivation produces the visual deprivation syndrome in Macaca mulatto. Brain Research 129, 37–44.CrossRefGoogle Scholar
Von Noorden, G.K. & Crawford, M.L.J. (1981). The effects of total unilateral occlusion vs. lid suture on the visual system of infant monkeys. Investigative Ophthalmology and Visual Science 21, 142–146.Google ScholarPubMed
Wilson, J.R., Tigges, M., Boothe, R.G., Tigges, J. & Gammon, J.A. (1991). Effects of aphakia on the geniculostriate system of infant rhesus monkeys. Acta Anatomica 142, 193–203.CrossRefGoogle ScholarPubMed