In this exploratory study into the relationship between participation in charitable activity and self-reported measures of personal wellness, social exchange theory was used to model factors that operationalize socioeconomic variables as costs, religious orientation and charitable orientation as rewards, and wellness as profit. Structural equation modeling was applied to data from the 2004 General Social Survey, including the Module on Altruism, to measure the effects, both direct and indirect, and infer knowledge from the results. Results suggest the indication of a relationship between charitable behavior and personal wellness is valid. Specifically, those who are more charitable and those with an enhanced religious orientation exhibit greater wellness. Results also indicate that charitable orientation acts as a mediating variable between income, education, religiosity, and wellness.