Skip to main content
×
×
Home

Health benefits and potential applications of anthocyanins in poultry feed industry

  • L. CHANGXING (a1) (a2), M. CHENLING (a3), M. ALAGAWANY (a4), L. JIANHUA (a2), D. DONGFANG (a2), W. GAICHAO (a5), Z. WENYIN (a3), S.F. SYED (a6), M.A. ARAIN (a5) (a6), M. SAEED (a1), F.U. HASSAN (a6) (a7) and S. CHAO (a1)...
Abstract

Anthocyanins are flavonoids widely spread in various plant species as a major phyto-pigment. In recent years, interest in using anthocyanins as a feed ingredient has increased markedly owing to their health and other benefits. Anthocyanins possess various pharmacological properties, including anti-inflammatory, immunomodulatory, anticancer, antidiabetic, neuroprotective, anti-obesity and antioxidant effects. Dietary consumption of anthocyanins has revealed benefits in animal performance. Little is known about health-promoting effects of anthocyanins in avian species, but anthocyanin-rich dried fruits have shown positive effects on certain pathological conditions and health promoting markers in human and other animals. This review aims to gather information regarding health benefits of anthocyanins and highlight therapeutic and potential health beneficial effects of anthocyanins for poultry. Additionally, it explores these biologically important flavonoids as alternative ingredients in poultry feed to replace synthetic nutrients and medicines. The available literature reports studies involving use of anthocyanins focused on human, mice and in vitro models. However, there is a need to explore mechanism of action at molecular level to understand potential beneficial effects of anthocyanins in avian species.

Copyright
Corresponding author
Corresponding author: sunchao2775@163.com
References
Hide All
AHOSSI, P.K., DOUGNON, J.T., KIKI, P.S. and HOUESSIONON, J.M. (2016) . Effects of Tridax procumbens powder on zootechnical, biochemical parameters and carcass characteristics of Hubbard broiler chicken. Journal of Animal Health and Production 4: 15-21.
ALLEN, R.G. and TRESINI, M. (2000) Oxidative stress and gene regulation. Free Radical Biology and Medicine 28: 463-499.
ALVAREZ-SUAREZ, J.M., GIAMPIERI, F., TULIPANI, S., CASOLI, T., DI STEFANO, G., GONZALEZ-PARAMAS, A.M., SANTOS-BUELGA, C., BUSCO, F., QUILES, J.L., CORDERO, M.D., BOMPADRE, S., MEZZETTI, B. and BATTINO, M. (2014) One-month strawberry-rich anthocyanin supplementation ameliorates cardiovascular risk, oxidative stress markers and platelet activation in humans. Journal of Nutritional Biochemistry 25: 289-294.
AMNUEYSIT, P., TATAKUL, T., CHALERMSAN, N. and AMNUEYSIT, K. (2010) Effects of purple field corn anthocyanins on broiler heart weight. Asian Journal of Food and Agro-Industry 3: 319-327.
ARAIN, M.A., MEI, Z., HASSAN, F.U., SAEED, M., ALAGAWANY, M., SHAR, A.H. and RAJPUT, I.R. (2018) Lycopene: a natural antioxidant for prevention of heat-induced oxidative stress in poultry. World's Poultry Science Journal 74 (1): (Accepted).
ARCHETTI, M., DORING, T.F., HAGEN, S.B., HUGHES, N.M., LEATHER, S.R., LEE, D.W., LEV-YADUN, S., MANETAS, Y., OUGHAM, H.J., SCHABERG, P.G. and THOMAS, H. (2009) Unravelling the evolution of autumn colours: An interdisciplinary approach. Trends in Ecology and Evolution 24: 166-173.
BOIVIN, D., BLANCHETTE, M., BARRETTE, S., MOGHRABI, A. and BELIVEAU, R. (2007) Inhibition of cancer cell proliferation and suppression of TNF-induced activation of NFkappaB by edible berry juice. Anticancer Research 27: 937-948.
BUENO, J.M., SAEZ-PLAZA, P., RAMOS-ESCUDERO, F., JIMENEZ, A.M., FETT, R. and ASUERO, A.G. (2012) Analysis and antioxidant capacity of anthocyanin pigments. Part ii: Chemical structure, colour, and intake of anthocyanins. Critical Reviews in Analytical Chemistry 42: 126-151.
BURDULIS, D., SARKINAS, A., JASUTIENE, I., STACKEVICENE, E., NIKOLAJEVAS, L. and JANULIS, V. (2009) Comparative study of anthocyanin composition, antimicrobial and antioxidant activity in bilberry (Vaccinium myrtillus L.) and blueberry (Vaccinium corymbosum L.) fruits. Acta Poloniae Pharmaceutica 66: 399-408.
CARDILE, V., FRASCA, G., RIZZA, L., RAPISARDA, P. and BONINA, F. (2010) Antiinflammatory effects of a red orange extract in human keratinocytes treated with interferon-gamma and histamine. Phytotherapy Research 24: 414-418.
CARVALHO, F.B., GUTIERRES, J.M., BOHNERT, C., ZAGO, A.M., ABDALLA, F.H., VIEIRA, J.M., PALMA, H.E., OLIVEIRA, S.M., SPANEVELLO, R.M., DUARTE, M.M., LOPES, S.T., AIELLO, G., AMARAL, M.G., PIPPI, N.L. and ANDRADE, C.M. (2015) Anthocyanins suppress the secretion of proinflammatory mediators and oxidative stress, and restore ion pump activities in demyelination. Journal of Nutritional Biochemistry 26: 378-390.
CESONIENE, L., JASUTIENE, I. and SARKINAS, A. (2009) Phenolics and anthocyanins in berries of European cranberry and their antimicrobial activity. Medicina-Lithuania 45: 992-999.
CHEN, J., ZHAO, Y., TAO, X.Y., ZHANG, M. and SUN, A.D. (2015) Protective effect of blueberry anthocyanins in a ccl4-induced liver cell model. LWT-Food Science and Technology 60: 1105-1112.
CHEN, P.N. (2006) Mulberry anthocyanins, cyaniding 3-rutino-side and cyaniding 3-glucoside, exhibited and inhibitory effect on the migration and invasion of a human lung cancer cell line. Cancer Letters 235: 248-259.
CISOWSKA, A., WOJNICZ, D. and HENDRICH, A.B. (2011) Anthocyanins as antimicrobial agents of natural plant origin. Natural Product Communications 6: 149-156.
DAVIES, K. (2004) Plant pigments and their manipulation. Economic Botany 92-92. Wiley-Blackwell, p. 6. ISBN 1-4051-1737-0.
DECENDIT, A., MAMANIMATSUDA, M., AUMONT, V., WAFFOTEGUO, P., MOYNET, D., BONIFACE, K., RICHARD, E., KRISA, S., RAMBERT, J. and MÉRILLON, J.M. (2013) Malvidin-3-o-β glucoside, major grape anthocyanin, inhibits human macrophage-derived inflammatory mediators and decreases clinical scores in arthritic rats. Biochemical Pharmacology 86: 1461.
FUKUMOTO, L.R. and MAZZA, G. (2000) Assessing antioxidant and prooxidant activities of phenolic compounds. Journal of Agricultural and Food Chemistry 48: 3597-3604.
GEE, J.M., DUPONT, M.S., DAY, A.J., PLUMB, G.W., WILLIAMSON, G. and JOHNSON, I.T. (2000) Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway. Journal of Nutrition 130: 2765-2771.
HAJATI, H., HASSANABADI, A., GOLIAN, A., NASSIRI-MOGHADDAM, H. and NASSIRI, M.R. (2015) The effect of grape seed extract and vitamin c feed supplementation on some blood parameters and hsp70 gene expression of broiler chickens suffering from chronic heat stress. Italian Journal of Animal Science 14.
HANIEH, H., GERILE, C., NARABARA, K., GU, Z.G., ABE, A. and KONDO, Y. (2010) In vivo immunomodulatory effects of dietary purple sweet potato after immunisation in chicken. Animal Science Journal 81: 116-121.
HE, J., WALLACE, T.C., KEATLEY, K.E., FAILLA, M.L. and GIUSTI, M.M. (2009) Stability of black raspberry anthocyanins in the digestive tract lumen and transport efficiency into gastric and small intestinal tissues in the rat. Journal of Agricultural and Food Chemistry 57: 3141-3148.
HOLLMAN, P.C.H. (2001) Evidence for health benefits of plant phenols: Local or systemic effects? Journal of the Science of Food & Agriculture 81: 842-852.
HWA, K.S., CHUNG, D.M., CHUNG, Y.C. and CHUN, H.K. (2011) Hypouricemic effects of anthocyanin extracts of purple sweet potato on potassium oxonate-induced hyperuricemia in mice. Phytotherapy Research 25: 1415-1417.
HWANG, Y.P., CHOI, J.H., YUN, H.J., HAN, E.H., KIM, H.G., KIM, J.Y., PARK, B.H., KHANAL, T., CHOI, J.M., CHUNG, Y.C. and JEONG, H.G. (2011a) Anthocyanins from purple sweet potato attenuate dimethylnitrosamine-induced liver injury in rats by inducing Nrf2-mediated antioxidant enzymes and reducing COX-2 and iNOS expression. Food and Chemical Toxicology 49: 93-99.
HWANG, Y.P., CHOI, J.H., HAN, E.H., KIM, H.G., WEE, J.H., JUNG, K.O., JUNG, K.H., KWON, K.I., JEONG, T.C., CHUNG, Y.C. and JEONG, H.G. (2011b) Purple sweet potato anthocyanins attenuate hepatic lipid accumulation through activating adenosine monophosphate-activated protein kinase in human hepg2 cells and obese mice. Nutrition Research 31: 896-906.
ICHIYANAGI, T., SHIDA, Y., RAHMAN, M.M., HATANO, Y. and KONISHI, T. (2006) Bioavailability and tissue distribution of anthocyanins in bilberry (Vaccinium myrtillus L.) extract in rats. Journal of Agricultural and Food Chemistry 54: 6578-6587.
JANG, H., HA, U.S., KIM, S.J., YOON, B.I., HAN, D.S., YUK, S.M. and KIM, S.W. (2010) Anthocyanin extracted from black soybean reduces prostate weight and promotes apoptosis in the prostatic hyperplasia-induced rat model. Journal of Agricultural and Food Chemistry 58: 12686-12691.
KAHKONEN, M.P. and HEINONEN, M. (2003) Antioxidant activity of anthocyanins and their aglycons. Journal of Agricultural and Food Chemistry 51: 628-633.
KANG, S.Y., SEERAM, N.P., NAIR, M.G. and BOURQUIN, L.D. (2003) Tart cherry anthocyanins inhibit tumor development in apc(min) mice and reduce proliferation of human colon cancer cells. Cancer Letter 194: 13-19.
KONG, J.M., CHIA, L.S., GOH, N.K., CHIA, T.F. and BROUILLARD, R. (2003) Analysis and biological activities of anthocyanins. Phytochemistry 64: 923-933.
KROON, P.A., CLIFFORD, M.N., CROZIER, A., DAY, A.J., DONOVAN, J.L., MANACH, C. and WILLIAMSON, G. (2004) How should we assess the effects of exposure to dietary polyphenols in vitro? The American Journal of Clinical Nutrition 80: 15-21.
LACOMBE, A., WU, V.C., WHITE, J., TADEPALLI, S. and ANDRE, E.E. (2012) The antimicrobial properties of the lowbush blueberry (Vaccinium angustifolium) fractional components against foodborne pathogens and the conservation of probiotic Lactobacillus rhamnosus. Food Microbiology 30: 124-131.
LEE, S.H., LILLEHOJ, H.S., LILLEHOJ, E.P., CHO, S.M., PARK, D.W., HONG, Y.H., CHUN, H.K. and PARK, H.J. (2008) Immunomodulatory properties of dietary plum on coccidiosis. Comparative Immunology Microbiology and Infectious Diseases 31: 389-402.
LEFEVRE, M., HOWARD, L., MOST, M., JU, Z. and DELANY, J. (2004) Microarray analysis of the effects of grape anthocyanins on hepatic gene expression in mice. Proceedings of the FASEB Journal, pp. 851-A851.
LEUSINK, G., REMPEL, H., SKURA, B., BERKYTO, M., WHITE, W., YANG, Y., RHEE, J.Y., XUAN, S.Y., CHIU, S., SILVERSIDES, F., FITZPATRICK, S. and DIARRA, M.S.. (2010) Growth performance, meat quality, and gut microflora of broiler chickens fed with cranberry extract. Poultry Science 89: 1514.
LI, L., WANG, L.Y., WU, Z.Q., YAO, L.J., WU, Y.H., HUANG, L., LIU, K., ZHOU, X. and GOU, D.M. (2014) Anthocyanin-rich fractions from red raspberries attenuate inflammation in both raw264.7 macrophages and a mouse model of colitis. Scientific Reports 4: 6234.
MATSUMOTO, H., ICHIYANAGI, T., IIDA, H., ITO, K., TSUDA, T., HIRAYAMA, M. and KONISHI, T. (2006) Ingested delphinidin-3-rutinoside is primarily excreted to urine as the intact form and to bile as the methylated form in rats. Journal of Agricultural And Food Chemistry 54: 578-582.
MAZZA, G. (1995) Anthocyanins in grapes and grape products. Critical Review in Food Science and Nutrition 35: 341-371.
MAZZA, G. and MINIATI, E. (1993) Anthocyanins in fruits, vegetables, and grains (CRC press).
MAZZA, G.J. (2007) Anthocyanins and heart health. Annali Dellistituto Superiore Di Sanita 43: 369.
MCGHIE, T.K. and WALTON, M.C. (2007) The bioavailability and absorption of anthocyanins: Towards a better understanding. Molecular Nutrition and Food Research 51: 702-713.
MCGHIE, T.K., AINGE, G.D., BARNETT, L.E., COONEY, J.M. and JENSEN, D.J. (2003) Anthocyanin glycosides from berry fruit are absorbed and excreted unmetabolised by both humans and rats. Journal of Agricultural and Food Chemistry 51: 4539-4548.
MPIANA, P.T., NGBOLUA, K.N., BOKOTA, M.T., KASONGA, T.K., ATIBU, E.K., TSHIBANGU, D.S. and MUDOGO, V. (2010) In vitro effects of anthocyanin extracts from justicia secunda vahl on the solubility of haemoglobin s and membrane stability of sickle erythrocytes. Blood Transfusion 8: 248-254.
NAZ, S., SIDDIQI, R., AHMAD, S., RASOOL, S.A. and SAYEED, S.A. (2007) Antibacterial activity directed isolation of compounds from punica granatum. Journal of Food Science 72: M341-345.
NOHYNEK, L.J., ALAKOMI, H.L., KAHKONEN, M.P., HEINONEN, M., HELANDER, I.M., OKSMAN-CALDENTEY, K.M. and PUUPPONEN-PIMIA, R.H. (2006) Berry phenolics: Antimicrobial properties and mechanisms of action against severe human pathogens. Nutrition and Cancer 54: 18-32.
POJER, E., MATTIVI, F., JOHNSON, D. and STOCKLEY, C.S. (2013) The case for anthocyanin consumption to promote human health: A review. Comprehensive Reviews In Food Science and Food Safety 12: 483-508.
PRIOR, R.L. and WU, X.L. (2006) Anthocyanins: Structural characteristics that result in unique metabolic patterns and biological activities. Free Radical Research 40: 1014-1028.
QUIROZ-CASTAÑEDA, R.E. and DANTÁN-GONZÁLEZ, E. (2015) Control of avian coccidiosis: Future and present natural alternatives. Biomed Research International 2015: article ID 430610.
RIAZ, M., ZIA-UL-HAQ, M. and SAAD, B. (2016) Anthocyanins absorption and metabolism. Springer International Publishing pp. 57-69 (Springer).
SAEED, M., ABD EL-HACK, M.E., ALAGAWANY, M., ARAIN, M.A., ARIF, M., MIRZA, M.A., NAVEED, M., CHAO, S., SARWAR, M., SAYAB, M. and DHAMA, K. (2017a) Chicory (cichorium intybus) herb: Chemical composition, pharmacology, nutritional and healthical applications. International Journal of Pharmacology 13: 351-360.
SAEED, M., BABAZADEH, D., ARIF, M., ARAIN, M.A., BHUTTO, Z.A., SHAR, A.H., KAKAR, M.U., ANZOOR, R. and CHAO, S. (2017b) Silymarin: a potent hepatoprotective agent in poultry industry. World's Poultry Science Journal 73: 483-492.
SAEED, M., NAVEED, M., ARAIN, M.A., ARIF, M., EL-HACK, M.E.A., ALAGAWANY, M., SIYAL, F.A., SOOMRO, R.N. and SUN, C. (2017c) Quercetin: Nutritional and beneficial effects in poultry. World's Poultry Science Journal 73: 355-364.
SAPUTRA, Y., SUTHAMA, N. and SUKAMTO, B. (2016) Supplementation of purple sweet potato extract on protein digestibility and meat protein mass in broiler reared under different cage density. Proceedings of International Seminar on Livestock Production and Veterinary Technology LPVT-2016-p.378-384.
SCALBERT, A. and WILLIAMSON, G. (2000) Dietary intake and bioavailability of polyphenols. Journal of Nutrition 130: 2073S-2085S.
SEERAM, N.P., MOMIN, R.A., NAIR, M.G. and BOURQUIN, L.D. (2001) Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries. Phytomedicine 8: 362-369.
SILVA, S., COSTA, E.M., COSTA, M.R., PEREIRA, M.F., PEREIRA, J.O., SOARES, J.C. and PINTADO, M.M. (2015) Aqueous extracts of vaccinium corymbosum as inhibitors of Staphylococcus aureus. Food Control 51: 314-320.
SINGLETARY, K.W., JUNG, K.J. and GIUSTI, M. (2007) Anthocyanin-rich grape extract blocks breast cell DNA damage. Journal of Medicinal Food 10: 244-251.
SMERIGLIO, A., BARRECA, D., BELLOCCO, E. and TROMBETTA, D. (2016) Chemistry, pharmacology and health benefits of anthocyanins. Phytotherapy Research 30: 1265-1286.
STASTNIK, O., KARASEK, F., ROZTOCILOVA, A., DOLEZAL, P., MRKVICOVA, E. and PAVLATA, L. (2014) The influence of feeding wheat with purple grain to performance and biochemical parameters of broiler chickens. Proceedings of the International Ph.d. Students Conference on Mendelnet.
STASTNIK, O., MRKVICOVA, E., KARASEK, F., TROJAN, V., VYHNANEK, T., HRIVNA, L. and JAKUBCOVA, Z. (2016) The influence of coloured wheat feeding on broiler chickens performance parameters. Proceedings of the International Ph.D. Students Conference on Mendelnet.
STRACK, D. and WRAY, V. (1989) . Anthocyanins, in: DEY, P.M. & HARBORNE, J.B. (Eds) Methods in Plant Biochemistry (San Diego, CA: Academic Press).
TEDESCO, I., LUIGI RUSSO, G., NAZZARO, F., RUSSO, M. and PALUMBO, R. (2001) Antioxidant effect of red wine anthocyanins in normal and catalase-inactive human erythrocytes. Journal of Nutritional Biochemistry 12: 505-511.
TSOYI, K., PARK, H.B., KIM, Y.M., CHUNG, J.I., SHIN, S.C., LEE, W.S., SEO, H.G., LEE, J.H., CHANG, K.C. and KIM, H.J. (2008) . Anthocyanins from black soybean seed coats inhibit uvb-induced inflammatory cylooxygenase-2 gene expression and pge2 production through regulation of the nuclear factor-κb and phosphatidylinositol 3-kinase/akt pathway. Journal of Agricultural & Food Chemistry 56: 8969-8974.
TSUDA, T., HORIO, F., UCHIDA, K., AOKI, H. and OSAWA, T. (2003) Dietary cyanidin 3-o-β-d-glucoside-rich purple corn colour prevents obesity and ameliorates hyperglycemia in mice. The Journal of Nutrition 133: 2125-2130.
TSUDA, T., SHIGA, K., OHSHIMA, K., KAWAKISHI, S. and OSAWA, T. (1996) Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from phaseolus vulgaris l. Biochemical Pharmacology 52: 1033-1039.
TSUDA, T., UENO, Y., YOSHIKAWA, T., KOJO, H. and OSAWA, T. (2006) Microarray profiling of gene expression in human adipocytes in response to anthocyanins. Biochemical Pharmacology 71: 1184-1197.
WALLE, T. (2004) Absorption and metabolism of flavonoids. Free Radical Biology Medecine 36: 829-837.
WANG, D., LEI, Y., MA, Y., ZHANG, L. and ZHAO, X. (2014) Inhibition of alv-a-induced apoptosis in df-1 cells via inactivation of nuclear transcription factor κb by anthocyanins from purple corn (Zea mays L.). Journal of Functional Foods 10: 274-282.
WANG, H., CAO, G. and PRIOR, R.L. (1997) Oxygen radical absorbing capacity of anthocyanins. Journal of Agricultural & Food Chemistry 45: 304-309.
WANG, J. and MAZZA, G. (2002) Inhibitory effects of anthocyanins and other phenolic compounds on nitric oxide production in lps/ifn-γ-activated raw 264.7 macrophages. Journal of Agricultural and Food Chemistry 50: 850-857.
WERLEIN, H.D., KUTEMEYER, C., SCHATTON, G., HUBBERMANN, E.M. and SCHWARZ, K. (2005) Influence of elderberry and blackcurrant concentrates on the growth of microorganisms. Food Control 16: 729-733.
WILLIAMSON, G., DAY, A.J., PLUMB, G.W. and COUTEAU, D. (2000) Human metabolic pathways of dietary flavonoids and cinnamates. Biochemical Society Transactions 28: 16-22.
WU, X., CAO, G. and PRIOR, R.L. (2002) Absorption and metabolism of anthocyanins in elderly women after consumption of elderberry or blueberry. Journal of Nutrition 132: 1865-1871.
YOU, J., KIM, J., LIM, J. and LEE, E. (2010) Anthocyanin stimulates in vitro development of cloned pig embryos by increasing the intracellular glutathione level and inhibiting reactive oxygen species. Theriogenology 74: 777-785.
YOUSUF, B., GUL, K., WANI, A.A. and SINGH, P. (2016) Health benefits of anthocyanins and their encapsulation for potential use in food systems: A review. Critical Reviews in Food Science and Nutrition 56: 2223-2230.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

World's Poultry Science Journal
  • ISSN: 0043-9339
  • EISSN: 1743-4777
  • URL: /core/journals/world-s-poultry-science-journal
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords