Skip to main content
×
×
Home

Fertility of mammalian spermatozoa: its development and relativity

  • R. Yanagimachi (a1)
Extract

Spermatozoa leaving the testis of normal animals are not ready to fertilise oocytes. They gain this ability while passing through the epididymis. It is interesting that spermatozoa of most animals take about 10 days to pass through the epididymis despite huge interspecies variations in the length of the epididymal tubule (e.g. some 30–50 m in large farm animals and about 1 m in the laboratory mouse) (Robaire & Hermo, 1988). The site where the spermatozoa begin to acquire fertilising capacity varies according to species, but it is generally the corpus epididymis or the proximal segment of the cauda epididymis where a large proportion of the spermatozoa become fertilisationcompetent. The distal segment of the cauda epididymis is the principal site for the storage of mature spermatozoa. Prolonged sojourn in the cauda epididymis (and vas deferens), however, could be detrimental to the spermatozoa.

Copyright
References
Hide All
Clark, E.N., Corron, M.E. & Florman, H.M.. 1993. Caltrin, the calcuim transport regulatory peptide of spermatozoa, modulates acrosome exocytosis in response to the egg's zone pellucide. J. Biol. Chem. 268,5309–16.
Cohen, J.. Malter, H.E.. et al.(eds). 1992. Micromanipulation of human Gametes and Embryos New york: Raven Press.
Cooper, T.G.. 1993. The human epididymis: is it necessary? Int. J. Androl. 16, 245–50.
Hirayama, T., Quinn, P. & Marrs, R.. 1991. Fertilizing ability of mouse sper matozoa from different regions of the epididymis midrosurgically injected into the perivitelline space of Oocytes. Am. Fert. Soc. Ann. Meet Abstr.(suppl to Fertil. Steril.)S 11 (abstr. 025).
Kierszenbaum, A.. 1994. Mammalian spermatogenesis in vivo and in vitro: a pertnership of spermatogenic and somatic cell lineages. Endocr. Rev. 15, 116–34.
Ogura, A., Matsuda, J..& Yanagimachi, R.. 1994. Birth of normal Young after electrofusion of mouse oocytes with round sPermatids. Proc. Natl. Acad. Sci. USA 91, 7460–62.
Palermo, G., Jpris, H.. et al. 1993. Sperm characteristics and outcome of human assisted fertilization by subzonal insemination and intracytoplasmic sperm injection. Fertil. Steril. 59, 826–35.
Patrizio, P., Silber, S.J..& Asch, R.H.. 1994. Correlation between epididymal length and fertilization rate in men with congenital absence of the vas deferens. Fertil. Steril. 61, 265–8.
Robaire, B..& Hermo, L.. 1988. Efferent ducts, epididymis, and vas deferens: structure, function and their regulations. In The Physiology of Reproduction, 1st edn ed. Knobil, E & Neill, JD, vol.1, PP. 9991080. New York: Raven.
Siler, S.J.. 1988. Pregnancy caused by sperm from vasa efferenta. Fertil. Steril. 49, 373–5.
VanSteirtegham, A.C.., 1993. High fertilizatin rates after intracytoplasmic spermic injection. Hum. Reprod. 8, 1061–6.
Wassarman, P.M.. 1990. Profile of a mammalian sperm receptor. Development. 108, 117.
Yanagimachi, R.. 1994. Mammalian fertilization. In The Physiology of Reprodution, 2nd edn, ed. Knobil, E & Neill, JD, pp. 189317. New York: Raven Press.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Zygote
  • ISSN: 0967-1994
  • EISSN: 1469-8730
  • URL: /core/journals/zygote
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed