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Reactive oxygen species in reproduction: harmful, essential or both?

Published online by Cambridge University Press:  28 April 2020

M. Jamil Open the ORCID record for M. Jamil [Opens in a new window] ,
H. Debbarh ,
S. Aboulmaouahib ,
O. Aniq Filali ,
K. Mounaji ,
M. Zarqaoui ,
B. Saadani ,
N. Louanjli  and
R. Cadi
M. Jamil*
Affiliation:
Laboratory of Molecular Genetic Physiopathology and Biotechnology. Department of Biology, Ain Chock Faculty of Sciences, HASSAN II University, Casablanca, Morocco IVF Center IRIFIV, Iris Clinic, Casablanca, Morocco
H. Debbarh
Affiliation:
Laboratory of Molecular Genetic Physiopathology and Biotechnology. Department of Biology, Ain Chock Faculty of Sciences, HASSAN II University, Casablanca, Morocco
S. Aboulmaouahib
Affiliation:
Labomac IVF Center and Clinical Laboratory Medicine, Casablanca, Morocco
O. Aniq Filali
Affiliation:
Laboratory of Molecular Genetic Physiopathology and Biotechnology. Department of Biology, Ain Chock Faculty of Sciences, HASSAN II University, Casablanca, Morocco
K. Mounaji
Affiliation:
Laboratory of Molecular Genetic Physiopathology and Biotechnology. Department of Biology, Ain Chock Faculty of Sciences, HASSAN II University, Casablanca, Morocco
M. Zarqaoui
Affiliation:
IVF Center IRIFIV, Iris Clinic, Casablanca, Morocco
B. Saadani
Affiliation:
IVF Center IRIFIV, Iris Clinic, Casablanca, Morocco
N. Louanjli
Affiliation:
IVF Center IRIFIV, Iris Clinic, Casablanca, Morocco Labomac IVF Center and Clinical Laboratory Medicine, Casablanca, Morocco
R. Cadi
Affiliation:
Laboratory of Molecular Genetic Physiopathology and Biotechnology. Department of Biology, Ain Chock Faculty of Sciences, HASSAN II University, Casablanca, Morocco
*
Author for correspondence: M. Jamil. Laboratory of Molecular Genetic Physiopathology and Biotechnology. Department of Biology, Ain Chock Faculty of Sciences, HASSAN II University, Casablanca, Morocco. E-mail: malakjamil93@gmail.com
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Summary

The process of embryonic development is crucial and radically influences preimplantation embryo competence. It involves oocyte maturation, fertilization, cell division and blastulation and is characterized by different key phases that have major influences on embryo quality. Each stage of the process of preimplantation embryonic development is led by important signalling pathways that include very many regulatory molecules, such as primary and secondary messengers. Many studies, both in vivo and in vitro, have shown the importance of the contribution of reactive oxygen species (ROS) as important second messengers in embryo development. ROS may originate from embryo metabolism and/or oocyte/embryo surroundings, and their effect on embryonic development is highly variable, depending on the needs of the embryo at each stage of development and on their environment (in vivo or under in vitro culture conditions). Other studies have also shown the deleterious effects of ROS in embryo development, when cellular tissue production overwhelms antioxidant production, leading to oxidative stress. This stress is known to be the cause of many cellular alterations, such as protein, lipid, and DNA damage. Considering that the same ROS level can have a deleterious effect on the fertilizing oocyte or embryo at certain stages, and a positive effect at another stage of the development process, further studies need to be carried out to determine the rate of ROS that benefits the embryo and from what rate it starts to be harmful, this measured at each key phase of embryonic development.

Keywords

Embryo developmentEmbryo qualityIn vitroOxidative stressReactive oxygen species
Type
Review Article
Information
Zygote , Volume 28 , Issue 4 , August 2020 , pp. 255 - 269
Copyright
© Cambridge University Press 2020

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