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Topical levocabastine for the treatment of perennial allergic rhinitis

Published online by Cambridge University Press:  29 June 2007

Samy Elwany  and
Mohamed Bassiouny
Samy Elwany*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Alexandria University School of Medicine, Alexandria, Egypt.
Mohamed Bassiouny
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Alexandria University School of Medicine, Alexandria, Egypt.
*
Address for correspondence: Samy Elwany, M.D., PO Box 267 (Sidi Gaber), Alexandria, Egypt.
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Abstract

The ultrastructure of the nasal mucosa following theuse of intranasal levocabastine was studied in 20 patients suffering from perennial allergic rhinitis. The patients received twice daily 0.05 per cent levocabastine spray with a treatment duration of four weeks. At the end of the treatment period regression of the allergic process was evidenced by progressive reappearance of normal cilia and microvilli on the columnar cells, decrease of intercellular oedema andcytoplasmic vacuoles, increased number of mucous acinar cells, gradualdecrease of vascular congestion, as well as diminished oedema fluid formation. The drug, however, had no effect on mast cell degranulationnor on eosinophilic infiltration. Normalization of the ultrastructural features correlated well with clinical improvement.

Considering the results of the present study, levocabastine nasal spray appears to be an effective treatment for perennial allergic rhinitis and can be used with, or as an alternative to, other anti-allergic medications.

Keywords

Rhinitis, allergic, perennialHistamine H receptor blockaderHistology, comparative

Information

Type
Main Atricles
Information
The Journal of Laryngology & Otology , Volume 111 , Issue 10 , October 1997 , pp. 935 - 940
Copyright
Copyright © JLO (1984) Limited 1997

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References

Badhwar, A. K., Druce, H. M. (1992) Allergic rhinitis. Clinical Allergy 76: 789–803.Google Scholar
Dechant, K. L., Goa, K. L. (1991) Levocabastine: A review of its pharmacological properties and therapeuticpotential as a topical antihistamine in allergic rhinitis and conjunctivitis. Drugs 41: 202–224.CrossRefGoogle Scholar
Elwany, S., Talaat, M., Talaat, M., Helmy, A. (1983) Allergic nasal mucosa following topical treatment with beclomethasone dipropionate (Bdp) aerosol. Journal of Laryngology and Otology 97: 165–176.Google Scholar
Elwany, S., Stephanos, W. (1983) Rhinitis medicamentosa: an experimental and histochemical study. ORL 45: 187–194.Google Scholar
Elwany, S. (1984) Further observations on nasal mucosal changes in scleroderma. Journal of Laryngology and Otology 98(9): 879–886.CrossRefGoogle ScholarPubMed
Elwany, S. (1985) Delayed ultrastructural radiation induced changes in human mesotympanic middle ear mucosa. Journal of Laryngology and Otology 99(4): 343–353.CrossRefGoogle ScholarPubMed
Frostad, A. B., Olsen, A. K. (1993) A comparison of topical levocabastine and sodium cromoglycate in the treatment of pollen-provoked allergic conjunctivitis. Clinicaland Experimental Allergy 23: 406–409.Google Scholar
Kirkegaard, J., Secher, C., Borum, P., Mygind, N. (1983) Inhibition of histamine-induced nasal symptoms by the H1-receptor antagonist chlorpheniramine. British Journal of Chest Diseases 77: 113–122.CrossRefGoogle Scholar
Klementsson, H., Andersson, M., Pipkorn, U. (1990) Allergen-induced increase in non-specific nasal reactivity is blocked by antihistamines without a clear cut relationship to eosinophil influx. Journal of Allergy and Clinical Immunology 83: 466–472.CrossRefGoogle Scholar
Palma-Carlos, A. G., Palma-Carlos, M. L., Rombaut, N. (1988) The effect of levocabastine nasal spray in nasal provocation tests. International Journal of Clinical Pharmacological Research 8: 25–30.Google ScholarPubMed
Schüsler-van Hees, M. T., Duchateau, G. S., Merkus, F. W. (1992) Influence of levocabastine suspension on ciliary beat frequency and mucociliary clearance. Allergy 47: 230–233.Google Scholar
Tomiyama, S., Ohnishi, M., Okuda, M. (1993) The dose and duration of effect of levocabastine, a newtopical H1-receptor antagonist, on nasal provocation reaction to allergen. American Journal of Rhinology 7: 85–88.Google Scholar
Toppozada, H., Talaat, M. (1975) Humannasal epithelium and cellular elements in chronic allergic rhinitis. ORL 37: 233–243.CrossRefGoogle ScholarPubMed
Toppozada, H., Talaat, M. (1976) Tunica propria in chronic allergic rhinitis. ORL 38: 86–98.CrossRefGoogle ScholarPubMed
Van den Bussche, G. (1986) Levocabastine hydrochloride. Drugs Future 11: 841–843.Google Scholar