Hostname: page-component-6766d58669-vgfm9 Total loading time: 0 Render date: 2026-05-19T08:16:37.614Z Has data issue: false hasContentIssue false
  • English
  • Français

Extra-pulmonary small cell carcinoma of the neopharynx: case report and review of neopharyngeal tumours after total laryngectomy

Published online by Cambridge University Press:  29 July 2009

A George ,
H Uppal ,
C Phelan  and
R Hughes
A George*
Affiliation:
Department of ENT, University Hospital of North Staffordshire, Stoke on Trent, UK
H Uppal
Affiliation:
Department of ENT, University Hospital of North Staffordshire, Stoke on Trent, UK
C Phelan
Affiliation:
Department of Histopathology, University Hospital of North Staffordshire, Stoke on Trent, UK
R Hughes
Affiliation:
Department of ENT, University Hospital of North Staffordshire, Stoke on Trent, UK
*
Address for correspondence: Mr A George, Department of ENT, University Hospital of North Staffordshire, Stoke on Trent ST4 7LN, UK. E-mail: Georgea288@aol.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

We report the first documented case in the world literature of primary extra-pulmonary small cell carcinoma occurring in the neopharynx following laryngectomy.

Method:

We present a case report and a review of the world literature regarding the management of tumours of the neopharynx and extra-pulmonary small cell carcinoma.

Results:

The paucity of cases of extra-pulmonary small cell carcinoma has resulted in many departments managing this neoplasm similarly to pulmonary small cell cancer. However, the site of the primary can have an impact on disease survival and treatment options.

Conclusion:

Neopharyngeal small cell carcinoma has not previously been reported. It should be managed in the same way as other extra-pulmonary small cell carcinomas occurring within the pharynx or larynx, with combined multi-drug chemotherapy and radiotherapy. Surgery has a limited role due to the aggressiveness of the disease and the high risk of local and distant spread at presentation.

Keywords

LaryngectomyPharynx NeoplasmsTumour Metastasis

Information

Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 2 , February 2010 , pp. 216 - 219
Copyright
Copyright © JLO (1984) Limited 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

1Stafford, ND, Mathews, RN. Reconstruction of the pharynx after laryngectomy and partial pharyngectomy. J Laryngol Otol 1988;102:45–8CrossRefGoogle ScholarPubMed
2McConnell, FMS, Hester, TR, Nahai, F, Jurkiewicz, MJ, Brown, RG. Free jejunal grafts for reconstruction of the pharynx and cervical oesophagus. Arch Otolaryngol 1981;107:476–81CrossRefGoogle Scholar
3Ariyan, S. The pectoralis major myocutaneous flap – a versatile flap for reconstruction in the head and neck. Plast Reconstr Surg 1979;63:73–81Google Scholar
4Carlson, GW, Thourani, VH, Codner, MA, Grist, WJ. Free gastro-omental flap reconstruction of the complex, irradiated pharyngeal wound. Head Neck 1997;19:68–713.0.CO;2-N>CrossRefGoogle ScholarPubMed
5Sullivan, PA, Hartig, GK. Dysphagia after total laryngectomy. Curr Opin Otolaryngol Head Neck Surg 2001;9:139–46Google Scholar
6Gibbons, RG, Halvorsen, RA, Foster, WL, Warner, D, Roberts, L, Postlethwait, RW et al. Esophageal lesions after total laryngectomy. Am J Radiol 1985;144:1197–200Google ScholarPubMed
7Balfe, DM, Koehler, RE, Setzen, M, Weymen, PJ, Baron, RL, Ogura, JH. Barium examination of the esophagus after total laryngectomy. Radiology 1982;143:501–8CrossRefGoogle ScholarPubMed
8Jung, TTK, Adams, GL. Dysphagia in laryngectomized patients. Otolaryngol Head Neck Surg 1980;88:25–33Google Scholar
9Nikolaou, A, Markou, K, Petridis, D, Vlachtsis, K, Nalbantian, M, Daniilidis, L. Factors influencing tumour relapse after total laryngectomy. B-ENT 2005;1:1–10Google Scholar
10Yuen, APW, Wei, WI, Hui, Y, Ho, WK. Comprehensive analysis of pharyngeal recurrence of laryngeal carcinoma after total laryngectomy. Am J Otolaryngol 1996;17:380–5Google Scholar
11Spector, GJ, Sessions, DG, Haughey, BH, Chao, CKS, Simpson, J, El-Mofty, S et al. Delayed regional metastases, distant metastases, and second primary malignancies in squamous carcinomas of the larynx and hypopharynx. Laryngoscope 2001;111:1079–87Google Scholar
12Ferlito, A, Rinaldo, A. Primary and secondary small cell neuroendocrine carcinoma of the larynx: a review. Head Neck 2008;30:518–24Google Scholar
13Cicin, I, Karagol, H, Uzunoglu, S, Ugun, K, Usta, U, Kocak, Z. Extrapulmonary small cell carcinoma compared with small-cell lung carcinoma. Cancer 2007;110:1068–76Google Scholar
14Vrouvas, J, Ash, DV. Extrapulmonary small cell cancer. Clin Oncol 1995;7:377–81Google Scholar
15Gould, VE, Memoli, V, Chejfec, G, Johannessen, JV. The APUD cell system and its neoplasms. Surg Clin North Am 1979;59:93–108Google Scholar
16Briggs, JC, Ibrahim, NBN. Oat cell carcinoma of the oesophagus: a clinicopathological study of 23 cases. Histopathology 1983;7:261–7CrossRefGoogle ScholarPubMed
17Weng, CT, Chu, PY, Liu, MT, Chen, MK. Small cell carcinoma of the head and neck: a single institution's experience and review of the literature. J Otolaryngol Head Neck Surg 2008;37:788–93Google ScholarPubMed
18Batsakis, JG, El Naggar, AK, Luna, M. Pathology consultation: neuroendocrine tumours of larynx. Ann Otol Rhinol Laryngol 1992;101:710–14CrossRefGoogle Scholar
19World Health Organization. The World Health Organization histological typing of lung tumours. Am J Clin Pathol 1982;77:123–6CrossRefGoogle Scholar
20Medyesy, DC, Wolf, R, Putnam, JB, Ajani, JA. Small cell carcinoma of the esophagus. Cancer 2000;88:262–73.0.CO;2-K>CrossRefGoogle Scholar