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The effect of local ventilation on a spatiotemporal model of airborne disease transmission in indoor spaces

Published online by Cambridge University Press:  15 July 2026

Alexander Pretty*
Affiliation:
School of Mathematics, Cardiff University , Cardiff, UK
Ian M. Griffiths
Affiliation:
Mathematical Institute, University of Oxford, Oxford, UK
Zechariah Lau
Affiliation:
School of Mathematics, Cardiff University , Cardiff, UK Mathematical Institute, University of Oxford, Oxford, UK
Katerina Kaouri
Affiliation:
School of Mathematics, Cardiff University , Cardiff, UK
*
Corresponding author: Alexander Pretty; Email: prettya@cardiff.ac.uk
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Abstract

We incorporate local ventilation effects into a spatially dependent generalisation of the Wells–Riley model for airborne disease transmission and consider a room in which an air purifier supplements the ventilation provided by a poorly functioning air-conditioning (AC) unit. Aerosol production and removal through ventilation, biological deactivation and gravitational settling as well as transport around a recirculating AC flow and global turbulent mixing are modelled using an advection–diffusion–reaction equation. This local ventilation model is compared with a global ventilation model, where all ventilation is treated as a global sink. We undertake this comparison for a weak purifier (clean air delivery rate of 140 m$^3$h$^{-1}$) and a strong purifier (clean air delivery rate of 1,000 m$^3$h$^{-1}$). For each purifier, we determine a total effective air exchange rate and compare against the global model with equivalent ventilation. We find that, as expected, the purifier removes fewer aerosols when the distance between the infectious person and the purifier is increased, resulting in a greater average aerosol concentration in the room. Moreover, the concentration is generally lowest when the infectious person is upstream of the purifier, located in regions where the airflow streamlines are directed into the purifier. For these infectious source locations, the global ventilation model significantly overestimates the concentration throughout the room. For infectious sources outside of these regions, there is generally good agreement between the models, particularly for the weak purifier. We also studied, for a fixed distance from the purifier, how the infection risk to a susceptible person varies as the infectious person changes location. A susceptible person faces the highest infection risk when they are directly downstream of the infectious person, where the aerosol concentration is the highest. There is better agreement between local and global ventilation models for the weak purifier than for the strong purifier since the weak purifier has less impact on the airflow in the room.

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Papers
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Author(s), 2026. Published by Cambridge University Press
Figure 0

Table 1. Parameters and their valuesTable 1 long description.

Figure 1

Table 2. Parameters for two purifiers, with λ=2×10−4$\lambda = 2\times 10^{-4}$ s−1$^{-1}$ (0.7 ACH)Table 2 long description.

Figure 2

Figure 1. A 3D room with dimensions Lx$L_x$, Ly$L_y$, Lz$L_z$ is shown in (a). A cylindrical local ventilation system crosses the two recirculating layers and the arclength coordinate ξ$\xi$ follows the recirculating loop. The computational domain (ξ,y)$(\xi ,y)$ is shown in (b).

Figure 3

Figure 2. The airflow streamlines in the (ξ,y)$(\xi ,y)$-plane are shown for (a) the weak purifier (vp=0.04$v_p = 0.04$) and (b) the strong purifier (vp=0.3$v_p = 0.3$). The shaded regions indicate streamlines that pass through the purifier inlet (left) and the purifier outlet (right).

Figure 4

Figure 3. In (a), the infectious source locations, x0$\boldsymbol{x}_0$, are depicted by filled circles and the regions where all streamlines are directed into the purifier inlet (Figure 2) are shaded for each purifier. In (b), the average aerosol concentration, $\bar {C}$, after 4 hours is shown for the weak (+$+$) and the strong (×$\times$) purifiers for these x0$\boldsymbol{x}_0$. The global ventilation cases are also shown in (b), depicted as horizontal lines (labelled with the ACH). The cases explored further in Figures 4 and 5 are indicated with circles.

Figure 5

Figure 4. Contour plots of the aerosol concentration C$C$ after 4 hours for an infectious source at x0$\boldsymbol{x}_0$ (3.4) with (d,θ)=(1,45∘)$(d,\theta ) = (1,45^{\circ })$ (see Figure 3a). The concentration is shown for (a) the weak purifier (Cp$C_p$) and (b) the equivalent global ventilation of 1.4 ACH (Cg$C_g$), both with contours at intervals of 10 aerosols/m3$^3$. The concentration is shown for (c) the strong purifier (Cp$C_p$) and (d) the equivalent global ventilation of 6 ACH (Cg$C_g$), both with contours at intervals of 3 aerosols/m3$^3$.

Figure 6

Figure 5. Contour plots of the aerosol concentration C$C$ after 4 hours for an infectious source at x0$\boldsymbol{x}_0$ (3.4) with (d,θ)=(3,90∘)$(d,\theta ) = (3,90^{\circ })$ (see Figure 3a). The concentration is shown for (a) the weak purifier (Cp$C_p$) and (b) the equivalent global ventilation of 1.4 ACH (Cg$C_g$), both with contours at intervals of 14 aerosols/m3$^3$. The concentration is shown for (c) the strong purifier (Cp$C_p$) and (d) the equivalent global ventilation of 6 ACH (Cg$C_g$), both with contours at intervals of 5 aerosols/m3$^3$. Additional dashed lines show where Cp=Cg$C_p = C_g$.

Figure 7

Figure 6. The infection risk, P$P$ (equation (2.9)), to the susceptible person at xs$\boldsymbol{x}_s$ (see (5.1)) after 1 hour with (a) ϕ=180∘$\phi = 180^{\circ }$ and (b) ϕ=90∘$\phi = 90^{\circ }$. Global ventilation cases are labelled with their ACH value (open symbols), and the equivalent local ventilation (purifier) is depicted by filled symbols of the same shape. Schematics in the lower axes show the locations of the infectious and susceptible people for each θ$\theta$.