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Correlation of human papillomavirus infection and clinical parameters with five-year survival in oral squamous cell carcinoma

Published online by Cambridge University Press:  11 June 2018

S M Adnan Ali ,
M S Awan ,
S Atif ,
N Ali  and
Y Mirza
S M Adnan Ali*
Affiliation:
Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan
M S Awan
Affiliation:
Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan
S Atif
Affiliation:
Aga Khan Medical College, Aga Khan University, Karachi, Pakistan
N Ali
Affiliation:
Aga Khan Medical College, Aga Khan University, Karachi, Pakistan
Y Mirza
Affiliation:
Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan
*
Address for correspondence: Dr S M Adnan Ali, Office of Academia and Research in Surgery, Department of Surgery, Aga Khan University Hospital, Stadium Road, PO Box 3500, Karachi 74800, Pakistan Fax: +92 21 3493 4294 E-mail: syed.adnan@aku.edu
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Abstract

Objective

This study associated Human Papillomavirus (HPV) infection and other clinical parameters with five-year survival of oral squamous cell carcinoma patients at a tertiary care hospital in Karachi, Pakistan.

Methods

A total of 140 patients diagnosed with oral squamous cell carcinoma were enlisted. HPV status and subtypes were established through polymerase chain reaction performed in a previously published study. Clinical data including five-year survival were obtained through institutional medical records.

Results

Ninety-five patients (67.9 per cent) were positive for HPV. Of these, 85 patients were HPV 16 positive while 2 patients were HPV 18 positive. The mean survival time for HPV positive patients was 44.3 months, whereas survival time for HPV negative patients was 46.9 months. Univariate analysis showed that HPV status in oral squamous cell carcinoma was not a statistically significant factor in determining five-year survival rate (p = 0.386).

Conclusion

There is a high prevalence of HPV positive oral squamous cell carcinoma in Pakistan; however, there is no difference in the five-year survival rate when compared to HPV negative oral squamous cell carcinoma.

Keywords

Oral PathologySquamous Cell CarcinomaHuman PapillomavirusSurvival
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 7 , July 2018 , pp. 628 - 635
Copyright
Copyright © JLO (1984) Limited, 2018 

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Footnotes

Dr S M Adnan Ali takes responsibility for the integrity of the content of the paper

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