Neuroendocrine Dysfunction Following Concussion: A Missed Opportunity for Enhancing Recovery?

doi:10.1017/9781139696432.028

26 - Neuroendocrine Dysfunction Following Concussion: A Missed Opportunity for Enhancing Recovery?

from Part III - Diagnosis and Management of Concussion

Published online by Cambridge University Press: 22 February 2019

Nigel Glynn and

Amar Agha

Edited by

Jeff Victoroff and

Erin D. Bigler

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Jeff Victoroff: Affiliation:
University of Southern California, Torrance
Erin D. Bigler: Affiliation:
Brigham Young University, Utah

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Summary

There are at least two conceptual frameworks within which to consider the occurrence of neuroendocrine disturbance following typical concussive brain injury (CBI). One: some tissue that orchestrates mammalian endocrine function is lodged in the head. An abrupt rattling blow to the brain might be expected to harm that tissue, or its connections, sometimes. Two: the human stress response is intimately affiliated with and conditioned by neuroendocrine function. As discussed in earlier chapters, the very common occurrence of persistent symptoms more than one year after a single typical CBI is plausibly accounted for, in part, by the risk of a cyclic reaction in which (1) hard-to-measure physical harm to stress management neural tissue (e.g., in the medial temporal lobe), and (2) even harder-to-measure organic change related to psychological stress, might become engaged in a self-reinforcing pattern of cerebral dysfunction. The present chapter, authored by a renowned authority on this subject, explains the state of the art of knowledge regarding neuroendocrine change after CBI. Even more than in the case of sleep disorders, post-CBI endocrine disorders are routinely overlooked. The title of this chapter crystalizes the author’s exhortation: clinicians may often be missing a chance to help.

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Type: Chapter
Information: Concussion and Traumatic Encephalopathy
Causes, Diagnosis and Management
, pp. 767 - 779

DOI: https://doi.org/10.1017/9781139696432.028 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2019

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