Introduction
Conduct disorders (CD) represent some of the most pervasive mental and behavioral disturbances, observed in 3–5% of children and adolescents globally (Erskine et al., Reference Erskine, Baxter, Patton, Moffitt, Patel, Whiteford and Scott2017; Sadler et al., Reference Sadler, Vizard, Ford, Marchesell, Pearce and Mandalia2018). The role of CD symptoms in precipitating antisocial aggressive behavior in adulthood has been debated within the developmental psychopathology literature (Fairchild et al., Reference Fairchild, Hawes, Frick, Copeland, Odgers, Franke and De Brito2019). CD serves as a criterion for diagnosing antisocial personality disorder (ASPD), a persistent pattern of disregard for and violation of others' rights. This pattern suggests some homotypic continuity in antisocial difficulties from childhood to adulthood. However, relatively high proportions of children and adolescents diagnosed with CD do not exhibit ASPD in adulthood (Copeland, Shanahan, Costello, & Angold, Reference Copeland, Shanahan, Costello and Angold2009). Instead, a significant number have been found to develop other disorders, including depression and anxiety (Kim-Cohen et al., Reference Kim-Cohen, Caspi, Moffitt, Harrington, Milne and Poulton2003). Indeed, the prognostic significance of CD for ASPD and aggressive behavior remains unclear because CD may overlap with broader risk factors that are more predictive of poorer mental health (Krueger, Markon, Patrick, & Iacono, Reference Krueger, Markon, Patrick and Iacono2005).
Existing longitudinal and cross-sectional studies support the claim that CD is part of a broader dimension of externalizing behavioral problems (Fairchild et al., Reference Fairchild, Hawes, Frick, Copeland, Odgers, Franke and De Brito2019), which in turn are part of a broader continuum of mental ill health. Researchers have highlighted the high prevalence of comorbidity among psychiatric diagnoses of various kinds, leading to the identification of a latent general psychopathology factor, colloquially termed the ‘p factor’ (Caspi et al., Reference Caspi, Houts, Belsky, Goldman-Mellor, Harrington, Israel and Moffitt2014; Caspi, Houts, Fisher, Danese, & Moffitt, Reference Caspi, Houts, Fisher, Danese and Moffitt2023). This factor is posited to play a key role in the emergence of various mental health difficulties (Caspi & Moffitt, Reference Caspi and Moffitt2018). The p factor can be estimated using different factor analytic models that have different theoretical implications, but are statistically similar in practice (Hyland et al., Reference Hyland, Murphy, Shevlin, Bentall, Karatzias, Ho and McElroy2021; van Bork, Epskamp, Rhemtulla, Borsboom, & van der Maas, Reference van Bork, Epskamp, Rhemtulla, Borsboom and van der Maas2017), in which the overlap in item responses on self-report measures is partitioned into that which all items share (i.e. a general factor), and that which subsets of items have in common, after considering the shared variance (i.e. specific factors). When applied to broadband psychopathology measures, the general p factor reflects individual differences in overall vulnerability to, or severity of, psychopathology (Caspi & Moffitt, Reference Caspi and Moffitt2018), whilst specific internalizing and externalizing factors reflect unique styles of expressing difficulties (Caspi et al., Reference Caspi, Houts, Belsky, Goldman-Mellor, Harrington, Israel and Moffitt2014).
The principles of the p factor have been extrapolated to CD research, advocating for the application of developmental-ontogenetic and hierarchical-dimensional models to investigate psychopathic traits, externalizing problems, and CD more comprehensively (Hoffmann et al., Reference Hoffmann, Evans-Lacko, Collishaw, Knapp, Pickles, Shearer and Maughan2023; Perkins et al., Reference Perkins, Joyner, Foell, Drislane, Brislin, Frick and Patrick2022). Grounded in these theoretical considerations, we propose that the relationship between CD in adolescence and subsequent aggressive behavior in adult male offenders is mediated by the general psychopathology factor.
Another potential mediator between adolescent CD and adulthood aggressive behavior is impairment in reflective functioning (RF). RF, referring to an individual's capacity to understand their own and others' mental states – including emotions, desires, intentions, and beliefs – might at least partly explain the link between psychopathology and aggression (Fonagy & Target, Reference Fonagy and Target1997; Fonagy, Target, Steele, & Steele, Reference Fonagy, Target, Steele and Steele1998; Luyten, Campbell, Allison, & Fonagy, Reference Luyten, Campbell, Allison and Fonagy2020). RF serves as the operationalization of mentalization theory (Fonagy et al., Reference Fonagy, Campbell, Constantinou, Higgitt, Allison and Luyten2022; Fonagy & Target, Reference Fonagy and Target1997) and impairments in this function can lead to disrupted recognition and regulation of emotions, as well as difficulties comprehending and interpreting empathetic responses, resulting in impulsivity and aggression. The role of mentalization, or RF, as a mediator of the association between psychopathology or personality traits and behavioral outcomes related to violence and aggression, has been highlighted in previous studies (Bo, Sharp, Lind, Simonsen, & Bateman, Reference Bo, Sharp, Lind, Simonsen and Bateman2023; Parada-Fernández, Herrero-Fernández, & Rodríguez-Arcos, Reference Parada-Fernández, Herrero-Fernández and Rodríguez-Arcos2023; Taubner, White, Zimmermann, Fonagy, & Nolte, Reference Taubner, White, Zimmermann, Fonagy and Nolte2013). Impairments in mentalization have been studied in men who offended with ASPD, and while the effectiveness of mentalization-based treatment (MBT) interventions for PD is recognized, the literature on MBT for adult who offended remains limited (Bateman, O'Connell, Lorenzini, Gardner, & Fonagy, Reference Bateman, O'Connell, Lorenzini, Gardner and Fonagy2016; Newbury-Helps, Feigenbaum, & Fonagy, Reference Newbury-Helps, Feigenbaum and Fonagy2017; Thomas & Jenkins, Reference Thomas and Jenkins2019).
In this nested study, our primary aim was to investigate the role of RF impairment and general psychopathology as potential mediators of the association between CD in adolescence and adult aggression among male offenders. By building upon prior research on RF as a marker of resilience (Bo et al., Reference Bo, Sharp, Lind, Simonsen and Bateman2023; Kealy, Rice, Seidler, Oliffe, & Ogrodniczuk, Reference Kealy, Rice, Seidler, Oliffe and Ogrodniczuk2021; Parada-Fernández et al., Reference Parada-Fernández, Herrero-Fernández and Rodríguez-Arcos2023; Taubner et al., Reference Taubner, White, Zimmermann, Fonagy and Nolte2013), we aimed to elucidate the mechanisms that could be instrumental in reducing aggressive behaviors and diminishing the stigma associated with individuals who have a history of CD. As not all individuals with CD develop into aggressive adults (Fairchild et al., Reference Fairchild, Hawes, Frick, Copeland, Odgers, Franke and De Brito2019), it is crucial to explore factors that contribute to this heterogeneity. Our study utilizes baseline data from participants recruited for the Mentalization for Offending Adult Males (MOAM) trial (Fonagy et al., Reference Fonagy, Yakeley, Gardner, Simes, McMurran, Moran and Bateman2020), before any intervention took place. Two main objectives were addressed: First, we sought to evaluate the structure of psychopathology in men who offended, and second, to determine the role of their current psychopathology and RF in mediating the relationship between CD in adolescence and aggressive behavior. We hypothesized that in addition to a direct pathway from CD to aggressive behavior, CD will also predict general psychopathology, which in turn will predict aggression via RF. In such a model, RF would mediate the impact of psychopathology, as represented by the p factor, on aggression, with individuals exhibiting lower levels of RF demonstrating a greater propensity for aggression. Alternative hypotheses were that CD alone contributes to reduced RF (irrespective of the p factor), or that the p factor completely mediates the relationship between CD and aggression (without the involvement of RF). To supplement these hypotheses, we conducted a further analysis to determine the specific factors contributing to the formation of the general p factor as a sensitivity analysis. By examining these hypotheses, we aimed to determine the interplay between CD, RF, the general psychopathology factor, and their contribution to aggressive tendencies in adult who offended.
Methods
Participants
This study conducted a secondary analysis of pre-treatment data from 313 adult male offenders under the National Probation Service (NPS) supervision. All participants met the criteria for personality difficulties and were invited to join the MOAM trial. The MOAM trial, a multisite randomized controlled study in an NHS setting, assessed the efficacy and cost-effectiveness of integrating MBT with probation as usual (PAU) against PAU alone (Fonagy et al., Reference Fonagy, Yakeley, Gardner, Simes, McMurran, Moran and Bateman2020). The sample's sociodemographic details are in Table 1.
Sociodemographic and main study variables
The trial evaluated MBT's role in diminishing aggressive and antisocial behaviors and enhancing health status and quality of life. To qualify, participants were male, 21 or older, supervised by NPS with at least six months left on their sentence. They fulfilled the DSM-IV criteria for ASPD, scored ⩾15 on the Modified Overt Aggression Scale (OAS-M; Endicott, Tracy, Burt, Olson, and Coccaro, Reference Endicott, Tracy, Burt, Olson and Coccaro2002), and had adequate English and cognitive skills for trial processes. Those convicted of child sexual offenses or primarily diagnosed with psychotic or neurodevelopmental disorders were excluded. Out of 364 potential participants, 313 were recruited due to refusal or imprisonment. All gave written consent, with approvals from the London–South East Research Ethics Committee (reference: 14/LO/1696) and the National Offender Management Service (reference: 2014-315). Assessment methods and participant selection are detailed in the trial protocol paper (Fonagy et al., Reference Fonagy, Yakeley, Gardner, Simes, McMurran, Moran and Bateman2020).
Measures
Conduct disorder (CD)
CD was retrospectively assessed using 15 questions from the ASPD section of the Structured Clinical Interview for DSM-IV Disorders (SCID-II; Gibbon, Spitzer, Williams, First, and Benjamin, Reference Gibbon, Spitzer, Williams, First and Benjamin1997). Among these questions, specific behaviors such as ‘Before the age of 15 often bullied, threatened, or intimidated others', ‘Before the age of 15 was physically cruel to people’, and ‘Before the age of 15 often lied to obtain goods or favors or to avoid obligations (i.e. ‘cons’ others)’ were included to assess CD. Participants meeting the criteria for conduct problems were assigned a score of ‘threshold or true,’ with an index ranging from 0 to 15. This index indicates the number of CD symptoms experienced before the age of 15. The SCID-II is a semi-structured diagnostic interview with demonstrated validity and reliability (Ullrich et al., Reference Ullrich, Deasy, Smith, Johnson, Clarke, Broughton and Coid2008), notably within offenders populations (Lobbestael, Leurgans, & Arntz, Reference Lobbestael, Leurgans and Arntz2011). In our current sample, the mean (average) and standard deviation for CD scores was 7.66 (s.d. = 3.46).
Adult psychopathology
Adult psychopathology was evaluated at the symptom level using several self-report items that align with the spectral level factors detailed in the Hierarchical Taxonomy of Psychopathology (HiTOP; Kotov et al., Reference Kotov, Waszczuk, Krueger, Forbes, Watson, Clark and Zimmerman2017). For Internalizing difficulties, the 12-item CORE-OM Problems and Symptoms subscale (Barkham et al., Reference Barkham, Leach, Lucock, Evans, Margison, Mellor-Clark and McGrath2001) was utilized, which has been validated and found reliable (Evans et al., Reference Evans, Connell, Barkham, Margison, McGrath, Mellor-Clark and Audin2002). Disinhibition, Detachment, Antagonism, and Psychoticism were each assessed using five items from the Personality Inventory for DSM-5, contributing to an additional 20 items (PID-5; Krueger, Derringer, Markon, Watson, and Skodol, Reference Krueger, Derringer, Markon, Watson and Skodol2012). In the present study, the PID-5 and CORE-OM demonstrated excellent internal consistency, with Cronbach's alphas of 0.914 and 0.915, respectively. The measures' average scores were 18.41 (s.d. = 12.40) and 22.89 (s.d. = 12.91) for the CORE-OM and the PID-5, respectively.
Reflective functioning (RF)
RF was measured as part of baseline assessment using the Brief Reflective Functioning Questionnaire (BRFQ; Luyten, under development). This 14-item self-report scale evaluates an individual's capacity to reflect on their own and others' mental states. Higher scores indicate more significant difficulties in RF. The BRFQ is derived from the Reflective Functioning Questionnaire (Fonagy et al., Reference Fonagy, Luyten, Moulton-Perkins, Lee, Warren, Howard and Lowyck2016), which shows good test-retest reliability and convergent validity within clinical and non-clinical samples (Euler et al., Reference Euler, Nolte, Constantinou, Griem, Montague and Fonagy2021). Briefer versions of the RFQ have been modeled with a single latent dimension (Müller et al., Reference Müller, Wendt, Spitzer, Masuhr, Back and Zimmermann2022). In the present study, the BRFQ demonstrated good internal consistency, with a Cronbach's alpha of 0.834. The mean score of this measure was 46.31 (s.d. = 15.22).
Aggressive behavior
Aggression was assessed using the Modified Overt Aggression Scale (OAS-M; Endicott et al., Reference Endicott, Tracy, Burt, Olson and Coccaro2002), a clinician-administered semi-structured interview that rates aggression over the past week across four scales: verbal aggression, aggression against objects, aggression against others, and auto-aggression (i.e. aggression towards oneself). The total weighted score is calculated by multiplying the sum of each subscale by its corresponding severity weight and then adding the weighted subscale scores together. The OAS-M was found to have robust validity, reliability, and commendable psychometric properties (Coccaro, Reference Coccaro2020). In the present study, the OAS-M mean weighted total score was 322.14 (s.d. = 177.46)
Statistical analyses
Structure of psychopathology and RF
Confirmatory factor analysis was employed to estimate four structural models of psychopathology utilizing items from both the 12 CORE-OM and 20 PID-5 items:
1. Single-Factor Model: All 32 items loaded onto a single factor.
2. Correlated Factors Model: Consisting of five correlated factors, each item loaded onto one of the following: internalizing, disinhibition, detachment, antagonism, or psychoticism.
3. Higher-Order Model: This was statistically equivalent to the correlated factors model but included a higher-order factor to predict the covariances between correlated factors.
4. Bifactor Model: All items loaded onto a general p factor as well as specific factors related to internalizing, disinhibition, detachment, antagonism, or psychoticism. An alternative bifactor model with three specific factors (internalizing, externalizing, and psychoticism) was also examined. Covariances were set to zero between the general p factor and each specific factor, and between each specific factor.
Reflective functioning assessment
The structure of the BRFQ has not been established. In line with previous studies, we utilized a single factor model to assess global RF (Schwarzer, Nolte, Fonagy, & Gingelmaier, Reference Schwarzer, Nolte, Fonagy and Gingelmaier2022; Stagaki et al., Reference Stagaki, Nolte, Feigenbaum, King-Casas, Lohrenz, Fonagy and Montague2022). Two items found to have less adequate fit to the RF factor were subsequently excluded from the final measurement.
We used the maximum likelihood estimator with robust standard errors in all analyses. Model fit was evaluated using several fit indices, including the Chi-square (χ2), Comparative Fit Index (CFI), Tucker–Lewis Index (TLI), and Root Mean Square Error of Approximation (RMSEA). Acceptable fit was indicated by CFI and TLI values ⩾ 0.90, and RMSEA values ⩽ 0.06 (Hu & Bentler, Reference Hu and Bentler1999). Although the χ2 statistic is sensitive to sample size, we report it for completeness. To compare models, we employed the Akaike information criteria (AIC) and Sample-size adjusted Bayesian information criteria (BIC). These indices impose penalties for model complexity and are suitable for comparing non-nested models. The evidence for preferring one model over another was determined by the difference in AIC or BIC between models (Murray & Johnson, Reference Murray and Johnson2013). A difference greater than 10 (in Both AIC and BIC) was taken as very strong evidence in favor of the competing model (Fabozzi, Focardi, Rachev, & Arshanapalli, Reference Fabozzi, Focardi, Rachev and Arshanapalli2014).
Reliability Analysis
We applied model-based reliability estimates to evaluate the reliability of the general and specific psychopathology factors, including:
1. Omega Hierarchical (ωH/ ωHs): Estimates the proportion of raw test score variance explained by the general factor/ a given specific factor with a cut-off of >0.08 considered as high.
2. Explained Common Variance (ECV/ECVs): Assesses the multidimensionality of a measure based on the proportion of modeled variance explained by the general factor/specific factor relative to the total modeled variance. ECV > 0.70 suggests a strong general factor (Dueber, Reference Dueber2016).
3. H Index: A measure of construct reliability based on the proportion of variance in indicators explained by the factor, divided by the variance in indicators unexplained by that factor (Hancock & Mueller, Reference Hancock, Mueller, Cudeck, du Toit and Sorbom2001).
4. Factor Determinacy (FD): Examines the precision of factor scores based on the correlation between factor scores and the actual factors. It is recommended that factor score estimates should only be used when FD > 0.90 (Gorsuch, Reference Gorsuch2013).
Additionally, we determined the total information functions for the general and specific psychopathology factors, employing weighted least squares means and variances adjusted estimates of the chosen bifactor model.
Mediation model
To determine the extent to which general psychopathology (M1) and RF (M2) mediate the association between CD during adolescence (X) and aggression in adulthood (Y), we used structural equation modeling (SEM). Our double mediation model utilized the OAS-M total weighted scores as the primary outcome variable (Y), regressing them on CD total scores (X) through a p factor (M1) and RF (M2). Additionally, in a sensitivity analysis, we inverted this relationship, regressing RF on the p factor, to evaluate the robustness of our directional assumption. Supplementary analyses included the examination of five alternative models, wherein the general p factor in the final SEM was replaced with each of the specific factors.
To determine the significance of both direct and indirect effects, 5000 bias-corrected and accelerated bootstrapping analyses were performed to yield 95% confidence intervals (CIs) (Hayes, Reference Hayes2013; Tofighi & MacKinnon, Reference Tofighi and MacKinnon2016). An effect was deemed significant if the CI excluded zero. Model parameters were adjusted if modification indices exceeded 10 in the BRFQ or 30 in the final SEM, and if there was substantive basis. Model fit was assessed based on previously defined criteria, and all analyses were run with the Lavaan package for RStudio (version 2023.06.0 + 421).
Results
Objective 1: structure of psychopathology and RF
An inter-item polychoric correlation matrix of the items included in the psychopathology factor is summarized in online Supplementary Table S1. The psychopathology single-factor model showed a poor fit to the data (see Table 2) with moderate to strong positive factor loadings (see online Supplementary Table S2). The correlated factors model displayed an acceptable absolute fit (RMSEA = 0.055). However, relative fit indices such as the TLI was marginally below the acceptable threshold of 0.09 (see Table 2 and online Supplementary Table S3 for the model's factor loadings). The correlated factors model fit better than the single-factor model (ΔAIC = 871.01, ΔBIC = 865.82). The higher-order model showed acceptable absolute fit RMSEA = 0.057) and near-acceptable relative fit (CFI and TLI < 0.09) as well (see Table 2 and online Supplementary Table S4). The higher-order model demonstrated a superior fit compared to the single-factor model (ΔAIC = 843.22, ΔBIC = 840.63), but fit worse than the correlated model (ΔAIC = −27.79, ΔBIC = −25.19). The bifactor model with a p factor and five specific factors (internalizing, disinhibition, detachment, antagonism, and psychoticism) provided an excellent fit to the data (χ2(432) = 779, p < 0.001, TLI = 0.905, CFI = 0.917, RMSEA = 0.052), and outperformed the single-factor model (ΔAIC = 903.00, ΔBIC = 886.39), the correlated-factors model (ΔAIC = 31.99, ΔBIC = 20.57), and the higher-order model (ΔAIC = 59.78, ΔBIC = 45.76). Table 3 illustrates the standardized factor loadings for this bifactor model. In contrast, an alternative bifactor model that consolidated the three externalizing subscales into a single factor, fit worse than the bifactor model with five specific factors (ΔAIC = 3792.85, ΔBIC = 3790.89). It had the worst fit parameters in comparison with the single-factor, correlated, and higher-order models (χ2(525) = 1067, p < 0.001, TLI = 0.856, CFI = 0.873, RMSEA = 0.061, see items loadings in online Supplementary Table S5). We therefore used the bifactor model with a p factor and five specific factors in further SEM analyses.
Model fit parameters for CFA and SEM models
Note: AIC, Akaike information criterion; BIC, Bayesian information criterion; BRFQ, Brief Reflective Functioning Questionnaire; CFI, Comparative Fit Index; RMSEA, Root Mean Square Error of Approximation; TLI: Tucker–Lewis Index.
Standardized factor loadings for the bifactor model with cross-loadings
Note: CORE, Clinical Outcomes in Routine Evaluation – Outcome Measure; ECV, Explained Common Variance; ECVs, Explained Common Variance subscale; M, mean; PID5BF, The Personality Inventory for DSM-5 – Brief Form; s.d., standard deviation; ω, Omega; ω, Omega subscale; ωH, Omega hierarchical; ωHs, Omega hierarchical subscale.
*** p < 0.001; **p < 0.01; *p < 0.05.
The p factor showed moderate positive factor loadings (M = 0.502, s.d. = 0.13) and high levels of information (see information function, Table 2 and online Supplementary Table S6), which is consistent with its high raw score reliability (ωH = 0.80), construct reliability (H = 93), and factor determinacy (FD = 0.94). In contrast, specific factors showed weak-to-moderate factor loadings, low information functions and subthreshold reliability indices (see online Supplementary Table S6). Whilst most reliability metrics indicated the dominance of the p factor over specific factors, ECV was split between the p factor (ECV = 0.57) and specific factors (ECVs = 0.43), with a bias towards the general factor. This indicates that the measurement model was multidimensional, making it important to model both general and specific factors in our SEM.
In the RF model, all items were loaded positively onto a single factor (M = 0.567, s.d. = 0.15), which showed a good fit to the data. Certain error covariances were freed to account for item overlap, as indicated by modification indices (e.g. ‘When I get angry, I say things without really knowing why I am saying them’ and ‘When I get angry, I say things that I later regret’). Online Supplementary Tables S7 and S8 present the RF factor analysis modification indices and item loadings, respectively. The single factor BRFQ model showed good fit of the data (χ2(45) = 88.91, p < 0.001, CFI = 0.959, TLI = 0.940, RMSEA = 0.057; AIC = 14 547.53, BIC = 14 669.53)
Objective 2: mediation models
Our hypothesized SEM, in which CD scores during adolescence predicted OAS-M aggression scores via the p factor and RF factor, provided good fit to the data: χ2(942) = 1471.62, p < 0.001, CFI = 0.901, TLI = 0.891, RMSEA = 0.045 (see Table 2 and Fig. 1; model modification indices are available in online Supplementary Table S9). CD during adolescence positively predicted aggression in adulthood, both directly and indirectly, through pathways involving the p factor and RF. In this mediation model, CD had a direct effect on OAS-M aggression scores, indicating that 1 point increase in CD symptoms was associated with a 0.27 increase in aggressive behavior score in adulthood. Additionally, each increase in CD scores was associated with a 0.29 increase in p factor scores, but not RF. A strong positive relationship was observed between the p factor and RF (β = 0.81), which subsequently associated with increased aggression scores (β = 0.26). Notably, the link between the p factor and the OAS-M scores was not independently significant within this model. The indirect pathway was statistically significant, where CD predicted p, which in turn positively associated with RF, which finally linked with elevated levels of aggression (B = 0.032, 95% CI [0.0002–0.071]). However, the indirect paths involving only the p factor (CD → p factor → OAS-M) and RF (CD → RF → OAS-M) as mediating the link between CD and aggression scores was not statistically significant (B = 0.012 and B = 0.011 respectively, both pathways had non-significant 95% CI).
Mediation model leading from conduct disorder in adolescence to aggressive behavior via general p factor and reflective functioning.
Note: Coefficients represent standardized regression weights and standard errors. OAS-M, Overt Aggression Scale – Modified. *p = 0.05. **p = 0.01. *** p = 0.001.
Alternative models
In a sensitivity analysis where the direction between the p factor and RF factor was reversed (e.g. CD → RF → p → OAS-M), the mediation effect was not significant (B = 0.011, 95% CI [−0.023 to 0.047]). In supplementary analyses, using specific factors as mediators instead of the p factor, only the specific psychoticism factor was a significant mediator between CD, RF, and OAS-M, but no model showed acceptable fit (see Table 2 and online Supplementary Figs S2–S6). Higher CD scores in adolescence predicted elevated psychoticism scores in adulthood, which in turn was linked with greater RF scores, and RF scores were associated with increased OAS-M scores (B = 0.015, 95% CI [0.003–0.033]; see online Supplementary Fig. S6).
Discussion
In this study, we examined the structure of psychopathology and RF in adult male who offended, and explored how these factors mediated the relationship between CD in adolescence and aggression in adulthood. Our results highlight that, of the models assessed, a bifactor model demonstrated the most optimal fit. This model integrated a general p factor and specific factors including internalizing, disinhibition, detachment, antagonism, and psychoticism. Its superiority in fit was evident when compared against correlated factors model, higher-order model, and single-factor model, based on criteria such as the AIC and BIC. Consistent with our expectations, CD during adolescence was associated with aggressive behavior in adulthood. In addition to this direct relationship, the pathway from CD to aggression was mediated by both the p factor and RF. Individuals with more CD symptoms, which were linked with higher general psychopathology and consequently with difficulties in RF, were more likely to display elevated aggression scores. When examined in isolation, neither the p factor nor the RF factor mediated the link between CD and aggression.
In relation to the first study objective, which focused on the structure of psychopathology in our samples, our findings support a transdiagnostic approach in assessing psychopathology among offenders. Data supported a bifactor model, with a p factor explaining the shared variance across domains and specific factors like internalizing, disinhibition, detachment, antagonism, and psychoticism explaining the variance amongst subsets of items. Although few studies have used the bifactor model in forensic groups, existing research recognizes a p factor alongside distinct psychopathology elements (Constantinou et al., Reference Constantinou, Goodyer, Eisler, Butler, Kraam, Scott and Fonagy2019; Ignatyev, Baggio, & Mundt, Reference Ignatyev, Baggio and Mundt2019). Concerns exist over the bifactor model's tendency to overfit noise in the data and unclear definitions of the p factor and specific factors (Bonifay & Cai, Reference Bonifay and Cai2017; Greene et al., Reference Greene, Eaton, Li, Forbes, Krueger, Markon and Kotov2019; Watts, Lane, Bonifay, Steinley, & Meyer, Reference Watts, Lane, Bonifay, Steinley and Meyer2020). There are also concerns that the ‘p factor’ is merely a methodological artifact. Specifically, critics argue that individuals without co-occurring problems or disorders tend to inflate correlations among various psychopathologies and that the p factor is weaker in models that incorporate data from multiple informants (Watts et al., Reference Watts, Meyer, Greene, Wood, Trull, Steinley and Sher2021, Reference Watts, Makol, Palumbo, De Los Reyes, Olino, Latzman and Sher2022). We would argue that none of these critiques rule out a p factor, since it has been validated against external criteria and shows stability like that of psychological traits. Rather, researchers should be more cautious in their interpretations of the p factor. We remain agnostic about the causal basis of the p factor in our sample, since we do not validate it against external measures or analyze longitudinal data which would speak to causal mechanisms. Instead, we use it as a statistical tool to summarize individual differences in the overlap amongst multiple conditions, which provides some index of severity, and helps us delve deeper into the constructs that tie together CD during adolescence and adult aggression.
Regarding the study's second objective, our mediation model revealed that adolescent CD positively influences adult aggression, both directly and mediated by the p and RF factors. The established link between CD and an increased risk for aggressive behaviors is well-documented (Fairchild et al., Reference Fairchild, Hawes, Frick, Copeland, Odgers, Franke and De Brito2019; Hodgins, Cree, Alderton, & Mak, Reference Hodgins, Cree, Alderton and Mak2008; North, Kotamarti, & Pollio, Reference North, Kotamarti and Pollio2022). In our study, this direct link between CD and aggressive behavior remained consistently strong across all main and alternative models, thereby bolstering the robustness of this established link. The significant indirect path from CD to aggression via the p factor underscores the important role of general psychopathology. The link between CD and the p factor was evident both in the main and the specific models, albeit weaker in the latter. This aligns with studies suggesting CD may underpin multiple psychopathologies (Kim-Cohen et al., Reference Kim-Cohen, Caspi, Moffitt, Harrington, Milne and Poulton2003; Krueger et al., Reference Krueger, Markon, Patrick and Iacono2005) and stresses the need to explore broader risk factors like parental behavior and childhood adversities when studying issues like CD or aggression (Boden, Fergusson, & Horwood, Reference Boden, Fergusson and Horwood2010). Importantly, the influence of p factor scores on the link between conduct issues and aggression was mediated by RF levels. While previous research linked various mental health difficulties, particularly severe personality disorders and comorbidity, to increased aggression (Girasek, Nagy, Fekete, Ungvari, & Gazdag, Reference Girasek, Nagy, Fekete, Ungvari and Gazdag2022; Weltens et al., Reference Weltens, Bak, Verhagen, Vandenberk, Domen, van Amelsvoort and Drukker2021; Whiting & Fazel, Reference Whiting, Fazel, Carpiniello, Vita and Mencacci2020) our model did not identify a significant link between p factor and aggressive behavior. Instead, the connection was mediated by RF impairments, indicating a noteworthy relationship between RF and aggressive behavior.
Our finding that RF mediates the relationship between general psychopathology and aggression underscores the importance of an individual's ability to reflect on their own mental states and those of others in the expression of aggressive behavior. Fonagy and Luyten (Reference Fonagy and Luyten2018) argued that conduct problems can lead to temporary or chronic difficulties in mentalizing, impairing the inhibition of interpersonal violence through empathy and perspective-taking. Our study supports this hypothesis and broadens it to include general psychopathology, especially among male offenders who exhibited prevalent CD symptoms during adolescence. The presence of CD during childhood and adolescence has been identified as a risk factor for a broad array of mental health issues and psychosocial difficulties (i.e. p), both of which can disrupt the development of RF and heighten the risk of later aggression (Fergusson, Horwood, & Lynskey, Reference Fergusson, Horwood and Lynskey1994). For instance, executive functioning impairments, common to various childhood and adolescent mental health conditions such as oppositional defiant disorder (ODD), attention deficit hyperactivity disorder (ADHD), and CD (Figueiredo, Ramião, Barroso, & Barbosa, Reference Figueiredo, Ramião, Barroso and Barbosa2022), have been linked to RF deficits in both healthy and clinical populations (Ogilvie, Stewart, Chan, & Shum, Reference Ogilvie, Stewart, Chan and Shum2011; Rutherford et al., Reference Rutherford, Byrne, Crowley, Bornstein, Bridgett and Mayes2018). Constructs that are related to RF, such as empathy and theory of mind (ToM) during childhood and adolescence, have been also found to predict later symptoms of ASPD, psychopathy, violence, and offending behavior (Frick & White, Reference Frick and White2008; Galán, Choe, Forbes, & Shaw, Reference Galán, Choe, Forbes and Shaw2017; Karoğlu, Ferguson, & Ó Ciardha, Reference Karoğlu, Ferguson and Ó Ciardha2022; Rhee et al., Reference Rhee, Woodward, Corley, Du Pont, Friedman, Hewitt and Zahn-Waxler2021). However, while ToM represents the cognitive capacity to understand others' mental states, and empathy incorporates an emotional dimension to this understanding, RF encompasses both cognitive and affective processes, enabling individuals to reflect upon and interpret behaviors considering underlying mental states. Consequently, RF is viewed as a more operationalized, comprehensive, integrative construct essential for effective interpersonal relationships and self-regulation, making it an especially pertinent target for therapeutic interventions aimed at offenders with ASPD traits.
At the neurocognitive level, RF is understood as reprocessing mental state information, enhancing empathy, and interpreting social cues, which are also essential to ToM. These functions may be diminished due to neurodevelopmental challenges, leading to difficulty in regulating emotions and impulses, especially in contexts related to aggression. This regulation requires ‘hot executive functions’ for adaptive responses and better understanding of oneself and others (Zelazo, Reference Zelazo2020). This perspective is consistent with research suggesting that the general psychopathology factor (p) mirrors impulsivity issues, explaining the correlation between psychopathology and RF (Carver, Johnson, & Timpano, Reference Carver, Johnson and Timpano2017). Furthermore, interrelations between CD, general psychopathology, RF, and aggression may arise from shared brain circuitry, especially within the orbitofrontal and ventromedial prefrontal cortex (PFC), areas associated with CD and key to mentalization processes (Bateman, Ryle, Fonagy, & Kerr, Reference Bateman, Ryle, Fonagy and Kerr2007; Rubia, Reference Rubia2011). Abnormalities in these regions, stemming from early-life risk factors, can contribute to heightened adult psychopathology, RF challenges, and aggression (De Brito, Viding, Kumari, Blackwood, & Hodgins, Reference De Brito, Viding, Kumari, Blackwood and Hodgins2013; Hiser & Koenigs, Reference Hiser and Koenigs2018).
Among five alternative models with each specific factor added as a mediator, only the specific psychoticism factor significantly mediated the relationship between CD and RF, subsequently linking to aggression. Psychoticism, reflecting the severity of mental health issues, is sometimes disregarded in assessing mental health difficulties, despite its prevalence in both clinical and community samples (Singh & Gupta, Reference Singh and Gupta2021; Van Os, Linscott, Myin-Germeys, Delespaul, & Krabbendam, Reference Van Os, Linscott, Myin-Germeys, Delespaul and Krabbendam2009). This distinctive nature of psychoticism within the broader construct of psychopathology in our results highlights the need to consider its singular contribution to our comprehension of mental health and aggressive behavior. Specific factors might represent psychopathological dimensions devoid of overlap with other dimensions, effectively studying ‘pure’ problem domains (Caspi et al., Reference Caspi, Houts, Belsky, Goldman-Mellor, Harrington, Israel and Moffitt2014). In this case, ‘pure’ psychoticism might reflect the degree of disorganized thought, a feature that parallels RF since both involve meta-cognitive abilities (Weijers et al., Reference Weijers, Ten Kate, Debbané, Bateman, De Jong, Selten and Eurelings-Bontekoe2020). Nonetheless, the mediation model did not show an acceptable fit to the data, nor did the specific psychoticism factor show acceptable levels of reliable, so we caution these interpretations.
In the context of treating conduct problems or antisocial/aggressive behaviors, practitioners often focus on specific diagnoses like CD, ODD, or ASPD, viewing these conditions as root causes. However, consistent with transdiagnostic approaches, psychological treatments might target both specific and broad underlying mechanisms (Barlow, Ellard, & Fairholme, Reference Barlow, Ellard and Fairholme2010; Bateman, Campbell, Luyten, & Fonagy, Reference Bateman, Campbell, Luyten and Fonagy2018). For example, in the START trial, both specific conduct difficulties and general psychopathology decreased throughout a parent-based intervention targeting teens at risk of antisocial behavior (Constantinou et al., Reference Constantinou, Goodyer, Eisler, Butler, Kraam, Scott and Fonagy2019). Similarly, interventions that emphasize externalizing mechanisms, such as impulsivity, self-control, goal setting and planning skills, and anger management, have been found not only to reduce criminal and aggressive behavior but also to enhance quality of life and social relationships (Elyasi, Bijandi, Bijandi, & Abdolmaleki, Reference Elyasi, Bijandi, Bijandi and Abdolmaleki2017; Ferguson, Conway, Endersby, & MacLeod, Reference Ferguson, Conway, Endersby and MacLeod2009; Shahsavarani et al., Reference Shahsavarani, Noohi, Heyrati, Mohammadi, Mohammadi and Sattari2016). Our model thus underscores the importance of addressing a spectrum of impairments and difficulties by concentrating on RF, a mental ability posited to underpin all human interaction. As such, it forms the foundation for the well-being of individuals across various mental health populations. MBT, in particular, seeks to cultivate healthier thought patterns, emotions, and behaviors, ultimately leading to a reduction in delinquent behavior.
Our findings should be interpreted with the following limitations in mind. First, although childhood conduct problems were identified as a significant risk factor for aggressive difficulties, not all children with conduct problems progress to adult psychopathology. Our mediation model merely outlines one potential developmental pathway. Second, we relied on self-report measures for psychopathology assessment and cross-sectional data, thus causality cannot be established. Third, the retrospective assessment of CD might be subject to memory and reporting biases. While some studies have reported a high concordance between prospective and retrospective assessments of childhood maltreatment, psychopathology (Scott, McLaughlin, Smith, & Ellis, Reference Scott, McLaughlin, Smith and Ellis2012), and the accuracy of self- reported offending history (Jolliffe et al., Reference Jolliffe, Farrington, Hawkins, Catalano, Hill and Kosterman2003), the validity of retrospectively assessing CD in adult offenders remains understudied. Future research should employ longitudinal designs and objective measures to assess the retrospective validity of psychopathology in offenders and to evaluate the pathway identified in the current study. Longitudinal studies could also address a significant methodological limitation in our study, arising from the reliance on cross-sectional data in the mediation analysis, which precludes establishing causal relationships among the observed variables. Although our alternative models partially mitigate concerns of reverse causation, longitudinal data would provide a more effective mean of establishing temporal precedence, an approach we intend to employ in future studies with this cohort. Considering the well-documented adverse life-course outcomes for individuals who follow antisocial developmental pathways (Healey, Knapp, & Farrington, Reference Healey, Knapp and Farrington2004), it is crucial for future research to investigate the interplay between factors such as impaired fear conditioning, callous-unemotional traits, brain variations linked to empathy and ToM, and environmental influences including unstable family backgrounds, as potential mediators and moderators of our identified pathways.
In conclusion, this investigation contributes valuable insights into psychopathology's structure in a forensic sample and underscores the mediating roles of the p factor and RF between CD and aggression. It emphasizes the importance for clinicians to assess general psychopathology moving beyond categorical diagnoses. Incorporating the theoretical perspective of general psychopathology with the operationalization concept of RF into future research could enhance our understanding of the underlying mechanisms connecting various psychiatric disorders to aggression. This approach could lead to more effective, holistic (or transdiagnostic) clinical strategies, especially in managing high-risk individuals with complex comorbidities, thereby improving intervention outcomes and reducing aggression in psychiatric settings. Our findings have substantial implications for the design and implementation of efficacious interventions for aggression and psychopathology among men who offended, such as MBT.
Supplementary material
The supplementary material for this article can be found at https://doi.org/10.1017/S003329172400062X
Acknowledgments
This report is independent research supported by the National Institute for Health Research - Health Technology Assessment (NIHR-HTA) and Care Research ARC North Thames. The views expressed in this publication are those of the authors and not necessarily those of the NIHR, or the Department of Health and Social Care. We would like to thank our esteemed colleagues at NHS England and HM Prison and Probation Service for their invaluable support and contributions throughout this study.
Competing interests
None.
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