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Prognostic significance of tumour progression and human papillomavirus in advanced tonsillar cancer classified as stage IVa

Published online by Cambridge University Press:  08 December 2014

E Park ,
K-Y Jung ,
S-Y Kwon ,
J-S Woo ,
J-G Cho ,
M W Park ,
I S Kim ,
S J Kim  and
S-K Baek
E Park
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea
K-Y Jung
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea
S-Y Kwon
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea
J-S Woo
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea
J-G Cho
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea
M W Park
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea
I S Kim
Affiliation:
Department of Pathology, Korea University College of Medicine, Seoul, Korea
S J Kim
Affiliation:
Department of Pathology, Korea University College of Medicine, Seoul, Korea
S-K Baek*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea
*
Address for correspondence: Dr S-K Baek, Anam-dong 5-ga 126–1, Seongbuk-gu, Seoul 136–705, South Korea Fax: + 822–925–5233 E-mail: mdskbaek@gmail.com
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Abstract

Objective:

To identify clinical factors that can explain the differences in treatment outcome, and examine the value of human papillomavirus infection as a prognostic biomarker in stage IVa tonsillar carcinomas.

Methods:

Fifty-nine patients with tonsillar carcinoma classified as stage IVa were retrospectively analysed for survival outcomes according to various clinical factors. Human papillomavirus infection was evaluated using a human papillomavirus DNA chip test and immunohistochemical staining for p16 and p53.

Results:

Lower disease-free survival rates were associated with increasing local invasiveness and nodal status. Although human papillomavirus positivity and p16 expression was more common in locally advanced tonsillar carcinomas with advanced nodal status, the overall survival rate was better for patients with human papillomavirus positive, p16-positive tumours.

Conclusion:

The disease-free survival rate may differ according to local tumour invasiveness and nodal status, even for stage IVa tonsillar cancers. Human papillomavirus infection may be a useful biomarker for predicting treatment outcomes for stage VIa tumours.

Keywords

Tonsillar NeoplasmsPrognosisNeoplasm StagingPapillomavirus Infectionsp16INK4 Proteinp53 Tumor Suppressor Protein

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 1 , January 2015 , pp. 86 - 92
Copyright
Copyright © JLO (1984) Limited 2014 

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