Hostname: page-component-6766d58669-kl59c Total loading time: 0 Render date: 2026-05-18T21:21:18.223Z Has data issue: false hasContentIssue false
  • English
  • Français

The prevalence of human papillomavirus in paediatric tonsils in Southwestern Ontario

Published online by Cambridge University Press:  04 October 2021

M Wojtera ,
J W Barrett ,
J E Strychowsky ,
A Dzioba ,
J Paradis ,
M Husein ,
M I Salvadori  and
A C Nichols
M Wojtera
Affiliation:
Schulich School of Medicine and Dentistry, London, Ontario, Canada
J W Barrett
Affiliation:
Schulich School of Medicine and Dentistry, London, Ontario, Canada Department of Otolaryngology – Head and Neck Surgery, London, Ontario, Canada
J E Strychowsky*
Affiliation:
Schulich School of Medicine and Dentistry, London, Ontario, Canada Department of Otolaryngology – Head and Neck Surgery, London, Ontario, Canada
A Dzioba
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, London, Ontario, Canada
J Paradis
Affiliation:
Schulich School of Medicine and Dentistry, London, Ontario, Canada Department of Otolaryngology – Head and Neck Surgery, London, Ontario, Canada
M Husein
Affiliation:
Schulich School of Medicine and Dentistry, London, Ontario, Canada Department of Otolaryngology – Head and Neck Surgery, London, Ontario, Canada
M I Salvadori
Affiliation:
Schulich School of Medicine and Dentistry, London, Ontario, Canada Pediatrics, Western University, London, Ontario, Canada
A C Nichols
Affiliation:
Schulich School of Medicine and Dentistry, London, Ontario, Canada Department of Otolaryngology – Head and Neck Surgery, London, Ontario, Canada
*
Author for correspondence: Dr Julie Strychowsky, Victoria Hospital B3-444, 800 Commissioners Rd East, London, Ontario N6A 5W9, Canada E-mail: julie.strychowsky@lhsc.on.ca Fax: +1 519 685 8185
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

To determine the prevalence of human papillomavirus in paediatric tonsils in Southwestern Ontario, Canada.

Materials and methods

Patients aged 0–18 years undergoing tonsillectomy were recruited. Two specimens (left and right tonsils) were collected from each participant. Tonsillar DNA was analysed using quantitative polymerase chain reaction to determine the presence of human papillomavirus subtypes 6, 11, 16 or 18.

Results

A total of 102 patients, aged 1–18 years (mean age of 5.7 years), were recruited. Ninety-nine surveys were returned. There were 44 females (44.4 per cent) and 55 males (55.6 per cent). Forty patients (40.4 per cent) were firstborn children and 73 (73.7 per cent) were delivered vaginally. Six mothers (6.1 per cent) and one father (1.0 per cent) had prior known human papillomavirus infection, and one mother (1.0 per cent) had a history of cervical cancer. All tonsil specimens were negative for human papillomavirus subtypes 6, 11, 16 and 18.

Conclusion

No human papillomavirus subtypes 6, 11, 16 or 18 were found in paediatric tonsil specimens from Southwestern Ontario.

Keywords

Human PapillomavirusHPV Human PapillomavirusTonsilPediatrics

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 3 , March 2022 , pp. 243 - 247
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

Footnotes

Dr J Strychowsky takes responsibility for the integrity of the content of the paper

References

Gillison, ML, Broutian, T, Pickard, RK, Tong, ZY, Xiao, W, Kahle, L et al. Prevalence of oral HPV infection in the United States 2009–2010. JAMA 2012;307:693–703CrossRefGoogle ScholarPubMed
Hocking, JS, Stein, A, Conway, EL, Regan, D, Grulich, A, Law, M et al. Head and neck cancer in Australia between 1982 and 2005 show increasing incidence of potentially HPV-associated oropharyngeal cancers. Br J Cancer 2011;104:886–91CrossRefGoogle ScholarPubMed
Chaturvedi, AK, Engels, EA, Anderson, WF, Gillison, ML. Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. J Clin Oncol 2008;26:612–19CrossRefGoogle ScholarPubMed
Mehanna, H, Beech, T, Nicholson, T, El-Hariry, I, McConkey, C, Paleri, V et al. Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer--systematic review and meta-analysis of trends by time and region. Head Neck 2013;35:747–55CrossRefGoogle ScholarPubMed
Syrjänen, S. HPV infections and tonsillar carcinoma. J Clin Pathol 2004;57:449–55CrossRefGoogle ScholarPubMed
Herrero, R, Castellsagué, X, Pawlita, M, Lissowska, J, Kee, F, Balaram, P et al. Human papillomavirus and oral cancer: The International Agency for Research on Cancer multicenter study. J Natl Cancer Inst 2003;95:1772–83CrossRefGoogle ScholarPubMed
Klussmann, JP, Weissenborn, SJ, Wieland, U, Dries, V, Kolligs, J, Jungehuelsing, M et al. Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas. Cancer 2001;92:2875–843.0.CO;2-7>CrossRefGoogle ScholarPubMed
Wojtera, M, Paradis, J, Husein, M, Nichols, AC, Barrett, JW, Salvadori, MI et al. The prevalence of human papillomavirus in pediatric tonsils: a systematic review of the literature. J Otolaryngol Head Neck Surg 2018;47:8CrossRefGoogle ScholarPubMed
Nichols, AC, Dhaliwal, SS, Palma, DA, Basmaji, J, Chapeskie, C, Dowthwaite, S et al. Does HPV type affect outcome in oropharyngeal cancer? J Otolaryngol Head Neck Surg 2013;42:9CrossRefGoogle ScholarPubMed
Qiagen. AllPrep DNA/RNA Mini Handbook: For simultaneous purification of genomic DNA and total RNA from the same animal cell or tissue sample. In: https://www.qiagen.com/us/resources/download.aspx?id=580866a6-56c6-4674-8566-2852164d8519&lang=en [29 September 2021]Google Scholar
Merck Canada. “Juvenile-Onset Recurrent Respiratory Papillomatosis in the Era of HPV” and “Vaccination Immunotherapy-Updates in the Treatment of Head and Neck Cancer”. Paper presented at: Canadian Society of Otolaryngology – Head and Neck Surgery 72nd Annual General Meeting, June 17–19, 2018, Quebec City, QC. In: https://www.entcanada.org/news-events/annual-meetings/quebec-city-2018/ [29 September 2021]Google Scholar
Clifford, GM, Rana, RK, Franceschi, S, Smith, JS, Gough, G, Pimenta, JM. Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancer. Cancer Epidemiol Biomarkers Prev 2005;14:1157–64CrossRefGoogle ScholarPubMed
Li, N, Franceschi, S, Howell-Jones, R, Snijders, PJF, Clifford, GM. Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: variation by geographical region, histological type and year of publication. Int J Cancer 2011;128:927–35CrossRefGoogle ScholarPubMed
Venuti, A, Paolini, F. HPV detection methods in head and neck cancer. Head Neck Pathol 2012;6:S63–74CrossRefGoogle ScholarPubMed
Bird, Y, Obidiya, O, Mahmood, R, Nwankwo, C, Moraros, J. Human papillomavirus vaccination uptake in Canada: a systematic review and meta-analysis. Int J Prev Med 2017;8:71CrossRefGoogle ScholarPubMed
Ogilvie, G, Anderson, M, Marra, F, McNeil, S, Pielak, K, Dawar, M et al. A population-based evaluation of a publicly funded, school-based HPV vaccine program in British Columbia, Canada: parental factors associated with HPV vaccine receipt. PLoS Med 2010;7:e1000270CrossRefGoogle ScholarPubMed