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Risk of contamination of lidocaine hydrochloride and phenylephrine hydrochloride topical solution: in vivo and in vitro analyses

Published online by Cambridge University Press:  30 July 2013

M Jog ,
R Sachidananda  and
K Saeed
M Jog*
Affiliation:
Department of Otolaryngology, Hampshire Hospitals NHS Foundation Trust, Royal Hampshire County Hospital, Winchester, UK
R Sachidananda
Affiliation:
Department of Otolaryngology, Hampshire Hospitals NHS Foundation Trust, Royal Hampshire County Hospital, Winchester, UK
K Saeed
Affiliation:
Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Royal Hampshire County Hospital, Winchester, UK
*
Address for correspondence: Mr M Jog, Department of Otolaryngology, Royal Hampshire County Hospital, Winchester SO22 5DG, UK Fax: 01962 824429 E-mail: mandar_jog@hotmail.com
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Abstract

Objective:

To investigate the risk of contamination of lidocaine hydrochloride 5 per cent weight/volume and phenylephrine hydrochloride 0.5 per cent weight/volume topical solution, both in patients (in vivo) and in the laboratory setting (in vitro).

Methods:

This paper reports a prospective study involving 10 samples of the lidocaine hydrochloride and phenylephrine hydrochloride topical anaesthetic spray. The samples were assessed for microbiological contamination after a single use on patients in a controlled laboratory environment. Additional samples were assessed for baseline contamination and later assessed for contamination in an in vitro setting.

Results:

In the in vivo setting, 2 of the 10 samples were positive for cultures from both the pump and the bottles. However, in the in vitro setting, the pump and the contents of the bottles were contaminated after a single use when the sterile solution was sprayed from distances of 1 and 2 cm.

Conclusion:

The lidocaine hydrochloride and phenylephrine hydrochloride topical solution assembly was contaminated in both in vivo and in vitro settings after a single use.

Keywords

Anesthetics, LocalCross InfectionLidocainePhenylephrineEndoscopyDrug Contamination

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 8 , August 2013 , pp. 799 - 801
Copyright
Copyright © JLO (1984) Limited 2013 

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References

1Bossart, PJ, Wolfe, T. Venturi atomizers as potential sources of patient cross-infection. Am J Infect Control 2003;31:441–4CrossRefGoogle ScholarPubMed
2Dubin, MG, White, DR, Melroy, CT, Gergan, MT, Rutala, WA, Senior, BA. Multi-use Venturi nasal atomizer contamination in a clinical rhinologic practice. Am J Rhinol 2004;18:151–6CrossRefGoogle Scholar
3Scianna, JM, Chow, JM, Hotaling, A. Analysis of possible cross-contamination with the Venturi system atomizer. Am J Rhinol 2005;19:503–7CrossRefGoogle ScholarPubMed
4Spraggs, PD, Hanekom, WH, Mochloulis, G, Joseph, T, Kelsey, MC. The assessment of the risk of cross-infection with a multi-use nasal atomizer. J Hosp Infect 1994;28:315–21CrossRefGoogle ScholarPubMed
5Wolfe, TR, Hillman, TA, Bossart, PJ. The comparative risks of bacterial contamination between a venturi atomizer and a positive displacement atomizer. Am J Rhinol 2002;16:181–6CrossRefGoogle Scholar
6Coakley, JF, Arthurs, GJ, Wilsher, TK. The need for and development of a single use disposable nasal spray. J Laryngol Otol 1993;107:20–3CrossRefGoogle ScholarPubMed
7Microbiology and pathology. In: www.hpa.org.uk/ProductsServices/InfectiousDiseases/UKStandardsForM [23 July 2012]Google Scholar
8Aydin, E, Hizal, E, Akkuzu, B, Azap, O. Risk of contamination of nasal sprays in otolaryngologic practice. BMC Ear Nose Throat Disord 2007;7:2CrossRefGoogle ScholarPubMed
9Rashid, M, Karagama, YG. Study of microbial spread when using multiple-use nasal anaesthetic spray. Rhinology 2011;49:281–5CrossRefGoogle ScholarPubMed
10Visosky, AM, Murr, AH, Ng, V, Dentoni, T, Weir, L, Haller, BL. Multiple-use atomizers in outpatient otolaryngology clinics are not necessarily an infectious risk. Otolaryngol Head Neck Surg 2003;128:447–51Google Scholar
11Sunkaraneni, VS, Jones, SE. Topical anaesthetic or vasoconstrictor preparations for flexible fibre-optic nasal pharyngoscopy and laryngoscopy. Cochrane Database Syst Rev 2011;(3):CD005606CrossRefGoogle ScholarPubMed