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An evaluation of vestibular functions in substance misuse

Published online by Cambridge University Press:  18 June 2025

Sanem Can Çolak Open the ORCID record for Sanem Can Çolak [Opens in a new window] ,
Deniz Uğur Cengiz Open the ORCID record for Deniz Uğur Cengiz [Opens in a new window] ,
Tuba Bayındır  and
Birgül Cumurcu
Sanem Can Çolak*
Affiliation:
Department of Audiology, Faculty of Health Sciences, İnönü University, Malatya, Turkey
Deniz Uğur Cengiz
Affiliation:
Department of Audiology, Faculty of Health Sciences, İnönü University, Malatya, Turkey
Tuba Bayındır
Affiliation:
Department of Otorhinolaryngology, Batıkent Medical Park Hospital, Ankara, Turkey
Birgül Cumurcu
Affiliation:
Department of Psychiatry, Faculty of Medicine, İnönü University, Malatya, Turkey
*
Corresponding author: Sanem Can Çolak; Email: sanemcan.colak@inonu.edu.tr
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Abstract

Objective

The aim of this study was to evaluate the vestibular system in substance addicts.

Methods

A total of 34 substance addicts were included in the study. A demographic data form, the Dizziness Handicap Inventory, the Addiction Profile Index Screening – Short Form, the Video Head Impulse Test, videonystagmography, and cervical and ocular vestibular evoked myogenic potentials tests were administered in all participants.

Results

A statistically significant difference was found between the study group and the control group (p < 0.05) in terms of gaze, saccade, pursuit and optokinetic results in the videonystagmography test; lateral, anterior and posterior semicircular canal gain values in the Video Head Impulse Test; P1 latency, P1–N1 interlatency, P1–N1 amplitude and asymmetry values in the cervical vestibular evoked myogenic potentials test; and N1–P1 interlatency, N1–P1 amplitude and asymmetry values in the ocular vestibular evoked myogenic potentials test (p < 0.05).

Conclusion

As a result of our study, it was observed that the vestibular system was affected in substance addicts.

Keywords

balancevertigoaudiologyneurotologyaddiction

Information

Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 139 , Issue 10 , October 2025 , pp. 928 - 933
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED.

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Footnotes

Sanem Can Çolak takes responsibility for the integrity of the content of the paper

Presented as an abstract at the 15th International Ear Nose Throat and Head and Neck Surgery Congress, 9–11 June 2023.

References

Dickman, JD. The vestibular system. In:. Fundamental Neuroscience for Basic and Clinical Applications, 1st edn. Philadelphia: Elsevier, 2018;320–33CrossRefGoogle Scholar
Gökler, R, Koçak, R. Uyuşturucu ve madde bağımlılığı. Sosyal Bilimler Araştırmaları Dergisi 2008;3:89–104Google Scholar
American Psychiatric Association. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders. Arlington: American Psychiatric Association, 2013Google Scholar
Rottach, KG, Wohlgemuth, WA, Dzaja, AE, Eggert, T, Straube, A. Effects of intravenous opioids on eye movements in humans: possible mechanisms. J Neurol 2002;249:1200–5CrossRefGoogle ScholarPubMed
Ramaioli, C, Colagiorgio, P, Saglam, M, Heuser, F, Schneider, E, Ramat, S, et al. The effect of vestibulo-ocular reflex deficits and covert saccades on dynamic vision in opioid-induced vestibular dysfunction. PLoS One 2014;9:e110322CrossRefGoogle ScholarPubMed
Ögel, K, Güneş, R, Koç, C, Görücü, S, Başabak, A. Bağımlılık Profil İndeksi (BAPİ) Ölçeğinin Kısa Formunun Geliştirilmesi, Geçerlilik ve Güvenilirlik Araştırması. Bağımlılık Dergisi 2015;16:175–81Google Scholar
Canbal, M, Cebeci, S, Çamur Duyan, G, Kurtaran, H, İ, Arslan. Baş Dönmesi Engellilik Envanterinin Türkçe Geçerlilik ve Güvenilirlik Çalışması. Turk J Family Med Primary Care 2016;10:19–24Google Scholar
Alpar, R. Uygulamalı İstatistik ve Geçerlik-Güvenirlik 6. Detay Yayıncılık: Ankara, 2020Google Scholar
Volkow, ND, Michaelides, M, Baler, R. The neuroscience of drug reward and addiction. Physiol Rev 2019;99:2115–40CrossRefGoogle ScholarPubMed
Müller, TE, Fontana, BD, Bertoncello, KT, Franscescon, F, Mezzomo, NJ, Canzian, J, et al. Understanding the neurobiological effects of drug abuse: lessons from zebrafish models. Prog Neuropsychopharmacol Biol Psychiatry 2020;100:109873CrossRefGoogle ScholarPubMed
Ishiyama, A, Ishiyama, G, Baloh, RW, Evans, CJ. Heroin-induced reversible profound deafness and vestibular dysfunction. Addiction 2001;99:1363–4Google Scholar
Rubin, A, Winston, J. The role of the vestibular apparatus in the production of nausea and vomiting following the administration of morphine to man: clinical and experimental data including the effects of dramamine and benzedrine. J Clin Invest 1950;29:1261–6CrossRefGoogle Scholar
Baykara, S, Alban, K. Erkek eroin bağimlilarinda fiziksel etkinlik düzeylerinin değerlendirilmesi. Anadolu Psikiyatri Derg 2017;18:211CrossRefGoogle Scholar
Lehnen, N, Heuser, F, Saglam, M, Schulz, CM, Wagner, KJ, Taki, M, et al. Opioid-induced nausea involves a vestibular problem preventable by head-rest. PLoS One 2015;10(8):e0135263CrossRefGoogle ScholarPubMed
Kurnatowski, P, Garganisz, J. Lesions of vestibular organs in opioid addicts: results of the tests recorded by electronystagmography. Eur Addict Res 1996;2:163–8CrossRefGoogle Scholar
da Silva Schmidt, PM, Giordani, AM, Rossi, AG, Cóser, P. Balance assessment in alcoholic subjects. Braz J Otorhinolaryngol 2010;76:148–55Google Scholar
Barnes, G. The effects of ethyl alcohol on visual pursuit and suppression of the vestibulo-ocular reflex. Acta Otolaryngol 1983;96:161–6CrossRefGoogle Scholar
Feyissa, AM, Masel, T, Busby, SP. Acute peripheral vestibulopathy in a cocaine addict: cracking the vestibular nucleus. Neurol Clin Pract 2014;4:532–3CrossRefGoogle Scholar
Carpenter, DO, Hori, D. Neurotransmitter and peptide receptors on medial vestibular nucleus neurons. Ann N Y Acad Sci 1996;656:668–86CrossRefGoogle Scholar
Popper, P, Cristobal, R, Wackym, P. Expression and distribution of μ opioid receptors in the inner ear of the rat. Neuroscience 2004;129:225–33CrossRefGoogle ScholarPubMed
Platzer, S, Winkler, A, Schadrack, J, Dworzak, D, Tölle, TR, Zieglgansberger, W, et al. Autoradiographic distribution of mu-, delta- and kappa 1-opioid stimulated [35S]guanylyl-5ʹ-O-(gamma-thio)-triphosphate binding in human frontal cortex and cerebellum. Neuro Lett 2000;283:213–16CrossRefGoogle Scholar
Odkvist, LM, Larsby, B, Tham, R, Aschan, G. On the mechanism of vestibular disturbances caused by industrial solvents. Adv Otorhinolaryngol 1979;25:167–72Google ScholarPubMed
Nylen, P, Larsby, B, Johnson, AC, Eriksson, B, Höglund, G, Tham, R. Vestibular-oculomotor, opto-oculomotor and visual function in the rat after long-term inhalation exposure to toluene. Acta Otolaryngol 1991;111:36–43CrossRefGoogle ScholarPubMed
Rosengren, SM, Weber, KP, Hegemann, SCA, Roth, TN. The effect of alcohol on cervical and ocular vestibular evoked myogenic potentials in healthy volunteers. Clin Neurophysiol 2014;125:1700–8CrossRefGoogle ScholarPubMed
Spector, M. Chronic vestibular and auditory effects of marijuana. Laryngoscope 1974;84:816–20CrossRefGoogle ScholarPubMed
Chiang, HH, Young, YH. Impact of alcohol on vestibular function in relation to the legal limit of 0.25 mg/l breath alcohol concentration. Audiol Neurootol 2007;12:183–8CrossRefGoogle Scholar
Treistman, SN. Electrophysiological approaches to studying ethanol targets. Alcohol Suppl 1991;1:191–5Google ScholarPubMed