Hostname: page-component-8448b6f56d-sxzjt Total loading time: 0 Render date: 2024-04-24T16:37:45.066Z Has data issue: false hasContentIssue false
  • English
  • Français

Does the human immunodeficiency virus influence the vestibulocollic reflex pathways? A comparative study

Published online by Cambridge University Press:  28 August 2014

B M Heinze ,
B M Vinck  and
D W Swanepoel
B M Heinze*
Affiliation:
Department of Speech-Language Pathology and Audiology, University of Pretoria, South Africa
B M Vinck
Affiliation:
Department of Speech-Language Pathology and Audiology, University of Pretoria, South Africa
D W Swanepoel
Affiliation:
Department of Speech-Language Pathology and Audiology, University of Pretoria, South Africa Ear Sciences Centre, School of Surgery, University of Western Australia, Nedlands, Australia Ear Science Institute Australia, Subiaco, Australia
*
Address for correspondence:Dr Barbara M Heinze, Department of Speech-Language Pathology and Audiology, Private Bag X20, Hatfield, Pretoria 0028, South Africa Fax: +27 12 4203517 E-mail: barbara.heinze@up.ac.za
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

This study compared vestibulocollic reflex and vestibulo-ocular reflex functioning in subjects with and without human immunodeficiency virus. It also described test results throughout progression of the disease and compared the results of human immunodeficiency virus positive subjects who were receiving antiretroviral therapies with those not receiving this treatment.

Methods:

Subjects comprised 53 adults with human immunodeficiency virus (mean age 38.5 ± 4.4 years) and 38 without human immunodeficiency virus (mean age 36.9 ± 8.2 years). Clinical examinations included cervical vestibular-evoked myogenic potential and bithermal caloric testing.

Results:

Abnormal cervical vestibular-evoked myogenic potential and caloric results were significantly higher in the human immunodeficiency virus positive group (p = 0.001), with an odds ratio of 10.2. Vestibulocollic reflex and vestibulo-ocular reflex involvement increased with progression of the disease. There were more abnormal test results in subjects receiving antiretroviral therapies (66.7 per cent) than in those not receiving antiretroviral therapies (63.6 per cent), but this difference was insignificant.

Conclusion:

Human immunodeficiency virus seems to influence vestibulocollic reflex pathways. Combining cervical vestibular-evoked myogenic potential and caloric testing may be useful to detect early neurological involvement in human immunodeficiency virus positive subjects.

Keywords

Human Immunodeficiency VirusVestibulocollic ReflexVestibulo-Ocular ReflexVestibular Evoked Myogenic PotentialsCaloric Testing
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 128 , Issue 9 , September 2014 , pp. 772 - 779
Copyright
Copyright © JLO (1984) Limited 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Goebel, JA. Practical anatomy and physiology. In: Goebel, JA, ed. Practical Management of the Dizzy Patient, 2nd edn.Philadelphia: Wolters Kluwer, 2008;1–13Google Scholar
2Fife, TD. Overview of anatomy and physiology of the vestibular system. In: Eggers, SDZ, Zee, DS, eds. Vertigo and Imbalance: Clinical Neurophysiology of the Vestibular System. Handbook of Clinical Neurophysiology. Amsterdam: Elsevier, 2010;9(2):5–17Google Scholar
3Ito, K, Ishimoto, S, Murofushi, T. Narrow internal auditory meatus: an idiopathic case confirming the origin and pathway of vestibular evoked myogenic potentials in humans. Arch Otolaryngol Head Neck Surg 2001;127:275–8Google Scholar
4Wilson, VJ, Boyle, R, Fukushima, K, Rose, PK, Shinoda, Y, Suqiuchi, Y et al. The vestibulocollic reflex. J Vestib Res 1995;5:147–70Google Scholar
5Rosengren, SM, Welgampola, MS, Colebatch, JG. Vestibular evoked myogenic potentials: past, present and future. Clin Neurophysiol 2010;121:636–51CrossRefGoogle ScholarPubMed
6Uchino, Y, Sato, H, Sasaki, M, Imaqawa, M, Ikeqami, H, Isu, N et al. Sacculocollic reflex arcs in cats. J Neurophysiol 1997;77:3003–12Google Scholar
7Colebatch, JG, Halmagyi, GM, Skuse, NF. Myogenic potentials generated by a click-evoked vestibulocollic reflex. J Neurol Neurosurg Psychiatry 1994;57:190–7CrossRefGoogle ScholarPubMed
8Colebatch, JG, Rothwell, JC. Motor unit excitability changes mediating vestibulocollic reflexes in the sternocleidomastoid muscle. Clin Neurophysiol 2004;115:2567–73Google Scholar
9Welgampola, MS, Colebatch, JG. Characteristics and clinical applications of vestibular-evoked myogenic potentials. Neurology 2005;64:1682–8CrossRefGoogle ScholarPubMed
10Wester, M. Vestibular evoked myogenic potentials. In: Atcherson, SR, Stoody, TM, eds. Auditory Electrophysiology: A Clinical Guide. New York: Thieme Medical Publishers, 2012;289–306Google Scholar
11Baloh, RW, Kerber, KA. Clinical Neurophysiology of the Vestibular System, 4th edn.Oxford: University Press, 2011Google Scholar
12Brandt, T, Strupp, M. General vestibular testing. Clin Neurophysiol 2005;116:406–26CrossRefGoogle ScholarPubMed
13Heinze, BM, Swanepoel, DW, Hofmeyr, LM. Systematic review of vestibular disorders related to human immunodeficiency virus and acquired immunodeficiency syndrome. J Laryngol Otol 2011;125:881–90Google Scholar
14Maes, L, Dhooge, I, D'haenens, W, Bockstael, A, Keppler, H, Philips, B et al. The effect of age on the sinusoidal harmonic acceleration test, pseudorandom rotation test, velocity step test, caloric test, and vestibular evoked myogenic potential test. Ear Hear 2010;31:84–94CrossRefGoogle ScholarPubMed
15CDC. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Recomm Rep 1992;41(RR-17):1–19Google Scholar
16Jerger, J. Clinical experience with impedance audiometry. Arch Otolaryngol 1970;92:311–24CrossRefGoogle ScholarPubMed
17Zikk, D, Rapoport, Y, Himelfarb, MZ. Invasive external otitis after removal of impacted cerumen by irrigation. N Engl J Med 1991;325:969–70Google Scholar
18Jongkees, LB, Maas, J, Philipszoon, A. Clinical nystagmography: a detailed study of electro-nystagmography in 341 patients with vertigo. Pract Otorhinolaryngol (Basel) 1962;24:65–93Google ScholarPubMed
19Jacobson, GP, Newman, CW, Peterson, EL. Interpretation and usefulness of caloric testing. In: Jacobson, GP, Newman, CW, Kartush, JM, eds. Handbook of Balance Function Testing. San Diego: Singular Publishing Group, 1997;193–234Google Scholar
20Barber, HO, Stockwell, CW. Manual of Electronystagmography, 2nd edn.St Louis: CV Mosby, 1980Google Scholar
21Maes, L, Vinck, BM, De Vel, E, D'Haenens, W, Bockstael, A, Keppler, H et al. The vestibular evoked myogenic potential: a test-retest reliability study. Clin Neurophysiol 2009;120:594–600Google Scholar
22Akin, FW, Murnane, OD.Vestibular evoked myogenic potentials. In: Jacobson, GP, Shepard, NT, eds. Balance Function Assessment and Management. San Diego: Plural Publishing, 2008;405–34Google Scholar
23Castello, E, Baroni, N, Pallestrini, E. Neurotological and auditory brain stem response findings in human immunodeficiency virus positive patients without neurologic manifestations. Ann Otol Rhinol Laryngol 1998;107:1054–60CrossRefGoogle ScholarPubMed
24Hausler, R, Vibert, D, Koralnik, IJ, Hirschel, B. Neuro-otological manifestations in different stages of HIV infection. Acta Otolaryngol Suppl 1991;481:515–21Google Scholar
25Teggi, R, Giordano, L, Pistorio, V, Bussi, M. Vestibular function in HIV patients: preliminary report. Acta Otolaryngol 2006;26: 140–6Google Scholar
26Teggi, R, Ceserani, N, Luce, FL, Lazzarin, A, Bussi, M. Otoneurological findings in human immunodeficiency virus positive patients. J Laryngol Otol 2008;122:1289–94CrossRefGoogle ScholarPubMed
27White, JA. Laboratory tests of vestibular and balance functioning. In: Hughes, GB, Pensak, ML, eds. Clinical Otology, 3rd edn.New York: Thieme, 2007;132–49Google Scholar
28Young, YH. Vestibular evoked myogenic potentials: a clinical tool for testing the inferior vestibular nerve integrity [in Chinese]. Acta Neurologica Taiwanica 2002;11:120–7Google Scholar
29Ozeki, H, Iwasaki, S, Ushio, M, Takeuchi, N, Murofushi, T. The lesion site of vestibular dysfunction in Ramsay Hunt syndrome: a study by click and galvanic VEMP. J Vestib Res 2006;16:217–22Google Scholar
30Zagólski, O. Vestibular-evoked myogenic potentials and caloric stimulation in infants with congenital cytomegalovirus infection. J Laryngol Otol 2008;122:574–9Google Scholar
31Meynard, JL, El Amrani, M, Meyohas, MC, Fligny, I, Gozlan, J, Rozenbaum, W et al. Two cases of cytomegalovirus infection revealed by hearing loss in HIV-infected patients. Biomed Pharmacother 1997;51:461–3CrossRefGoogle ScholarPubMed
32Vancíková, Z, Dvorák, P. Cytomegalovirus infection in immunocompetent and immunocompromised individuals–a review. Curr Drug Targets Immune Endocr Metabol Disord 2001;1:179–87CrossRefGoogle ScholarPubMed
33Matas, CG, Silva, SM, de Almeida Marcon, B, Gonçalves, IC. Electrophysiological manifestations in adults with HIV/AIDS submitted and not submitted to antiretroviral therapy. Pro Fono 2010;22:107–12CrossRefGoogle Scholar
34Moyle, G. Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity. Clin Ther 2000;22:911–36Google Scholar
35Warnke, D, Barreto, J, Temesgen, Z. Therapeutic review: antiretroviral drugs. J Clin Pharmacol 2007;47:1570–9Google Scholar
36Simdon, J, Watters, D, Bartlett, S, Connick, E. Ototoxicity associated with use of nucleoside analog reverse transcriptase inhibitors: a report of 3 possible cases and review of the literature. Clin Infect Dis 2001;32:1623–7CrossRefGoogle ScholarPubMed
37Cohen, HS, Cox, C, Springer, G, Hoffman, HJ, Young, MA, Margolick, JB et al. Prevalence of abnormalities in vestibular function and balance among HIV-seropositive and HIV-seronegative women and men. PLoS One 2012;7:1–7Google Scholar
38Bankaitis, AE, Keith, RW. Audiological changes associated with HIV infection. Ear Nose Throat J 1995;74:353–9Google Scholar
39Reyes-Contreras, L, Silva-Rojas, A, Ysunza-Rivera, A, Jiménez-Ruíz, G, Berruecos-Villalobos, P, Romo-Gutiérrez, G. Brainstem auditory evoked response in HIV-infected patients with and without AIDS. Arch Med Res 2002;33:25–8CrossRefGoogle ScholarPubMed
40Dellepiane, M, Medicina, MC, Mora, R, Salami, A. Static and dynamic posturography in patients with asymptomatic HIV-1 infection and AIDS. Acta Otorhinolaryngol Ital 2005;25:353–8Google Scholar