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Investigation of a Mycobacterium fortuitum prosthetic joint infection outbreak at two ambulatory surgery centers in Tennessee

Published online by Cambridge University Press:  14 October 2025

Simone Godwin Open the ORCID record for Simone Godwin [Opens in a new window] ,
Ashley Gambrell Open the ORCID record for Ashley Gambrell [Opens in a new window] ,
Becky A. Meyer Open the ORCID record for Becky A. Meyer [Opens in a new window] ,
Christopher Wilson ,
Melphine M. Harriott Open the ORCID record for Melphine M. Harriott [Opens in a new window] ,
Morgan Duckett ,
Kendall Ferrell ,
Morgan McMahan ,
Tracey Rhodes  and
Kelley M. Tobey
...Show all authors
Simone Godwin*
Affiliation:
Healthcare-Associated Infections and Antimicrobial Resistance Program of the Communicable and Environmental Diseases and Emergency Preparedness Division, Tennessee Department of Health, Nashville, TN, USA
Ashley Gambrell
Affiliation:
Healthcare-Associated Infections and Antimicrobial Resistance Program of the Communicable and Environmental Diseases and Emergency Preparedness Division, Tennessee Department of Health, Nashville, TN, USA
Becky A. Meyer
Affiliation:
Healthcare-Associated Infections and Antimicrobial Resistance Program of the Communicable and Environmental Diseases and Emergency Preparedness Division, Tennessee Department of Health, Nashville, TN, USA
Christopher Wilson
Affiliation:
Healthcare-Associated Infections and Antimicrobial Resistance Program of the Communicable and Environmental Diseases and Emergency Preparedness Division, Tennessee Department of Health, Nashville, TN, USA
Melphine M. Harriott
Affiliation:
Healthcare-Associated Infections and Antimicrobial Resistance Program of the Communicable and Environmental Diseases and Emergency Preparedness Division, Tennessee Department of Health, Nashville, TN, USA
Morgan Duckett
Affiliation:
Knox County Health Department, Knoxville, TN, USA
Kendall Ferrell
Affiliation:
Knox County Health Department, Knoxville, TN, USA
Morgan McMahan
Affiliation:
Knox County Health Department, Knoxville, TN, USA
Tracey Rhodes
Affiliation:
Healthcare-Associated Infections and Antimicrobial Resistance Program of the Communicable and Environmental Diseases and Emergency Preparedness Division, Tennessee Department of Health, Nashville, TN, USA
Kelley M. Tobey
Affiliation:
Healthcare-Associated Infections and Antimicrobial Resistance Program of the Communicable and Environmental Diseases and Emergency Preparedness Division, Tennessee Department of Health, Nashville, TN, USA
Megan Edwards
Affiliation:
Knox County Health Department, Knoxville, TN, USA
Corinne Tandy
Affiliation:
Knox County Health Department, Knoxville, TN, USA
*
Corresponding author: Simone Godwin; Email: Simone.Godwin@tn.gov
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Abstract

Objective:

This study outlines the investigation into an outbreak of Mycobacterium fortuitum infections involving 17 cases undergoing hip or knee surgeries at two ambulatory surgery centers (ASCs) in Tennessee from January 2023 to November 2024. Notably, the outbreak could not be attributed to contaminated water sources, which are typically associated with non-tuberculous mycobacteria (NTM) outbreaks, presenting a unique challenge.

Methods:

Outbreak investigation steps included Infection Prevention (IP) assessments, case-control study, environmental sampling, whole genome sequencing, and a healthcare personnel (HCP) exposure questionnaire.

Results:

IP assessment highlighted several concerns, including no formal facility water management program (WMP), a lack of dedicated IP personnel and certified sterile processing staff, the absence of a formalized system for tracking surgical site infections, and a notable gap in understanding the requirements for reporting diseases. The case-control findings revealed a significant association between the presence of a surgical technologist in the operating room during the procedures and the occurrence of NTM infections, indicated by an odds ratio of 55.77 (95% CI [3.16–985.44]; P = 0.0097). Thirteen clinical isolates collected at one ASC and three additional isolates collected at a second ASC were highly related by whole genome sequencing.

Conclusion:

The study further elucidates valuable insights gained from the outbreak response, including the gaps in surveillance within the ambulatory surgical setting and systematic collection of cultures from environmental sources. It emphasizes the importance of thorough vetting, onboarding, continuing education, and practice monitoring for HCP.

Information

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 46 , Issue 12 , December 2025 , pp. 1215 - 1221
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Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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