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Article contents
Contour improvements in skin graft reconstruction of nasal defects
Published online by Cambridge University Press: 17 December 2025
Abstract
Objectives
This study aimed to describe a one-stage technique for nasal skin defect reconstruction using an oxidised regenerated cellulose/collagen matrix (Promogran™) to enhance contour and graft survival.
Methods
Following excision of a skin lesion, Promogran™ is cut to size, placed in the wound bed to restore contour and provide bulk, saturated with blood and covered with a full-thickness skin graft.
Results
The technique improves cosmesis and enables graft survival over avascular structures, including exposed bone and cartilage. Promogran™ exerts wound-healing effects such as matrix metalloprotease inhibition, regulation of growth factors and cytokines, free-radical scavenging and fibroblast proliferation.
Conclusion
This simple, one-stage approach offers an alternative to complex or multistage reconstruction for patients unsuitable for, or preferring to avoid, more invasive procedures.
Keywords
Information
- Type
- Short Communications
- Information
- Copyright
- © The Author(s), 2025. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED.
Footnotes
Neil D McNiven takes responsibility for the integrity of the content of the paper
References
Nguyen, CV, Washington, CV, Soon, SL. Hydrocolloid dressings promote granulation tissue on exposed bone. Dermatol Surg 2013;39:123–5CrossRefGoogle ScholarPubMed
von Lindern, JJ, Niederhagen, B, Appel, T, Bergé, S. Treatment of soft tissue defects with exposed bone in the head and face region with alginates and hydrocolloid dressings. J Oral Maxillofac Surg 2002;60:1126–30CrossRefGoogle ScholarPubMed
Kok, K, White, N. Grafts and Local Flaps in Head and Neck Cancer. In: Watkinson, JC, Clarke, RW, editors. Scott-Brown’s Otorhinolaryngology, Head and Neck Surgery. 8th edn. Vol 3. Boca Raton, FL: CRC Press, 2018Google Scholar
Adams, DC, Ramsey, ML. Grafts in dermatologic surgery: review and update on full- and split-thickness skin grafts, free cartilage grafts, and composite grafts. Dermatol Surg 2005;31:1055–67CrossRefGoogle ScholarPubMed
Ramsey, ML, Walker, B, Patel, BC. Full-thickness skin grafts. In: StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing, 2023Google Scholar
Cullen, B, Smith, R, McCulloch, E, Silcock, D, Morrison, L. Mechanism of action of Promogran, a protease modulating matrix, for the treatment of diabetic foot ulcers. Wound Repair Regen 2002;10:16–25CrossRefGoogle ScholarPubMed
Guarnera, G, Restuccia, A. Promogran and complex surgical lesions: a case report. J Wound Care 2004;13:237–9CrossRefGoogle ScholarPubMed
Barrett, SA, Moore, K. Use of Promogran to treat venous leg ulcers. J Wound Care 2004;13:2–7CrossRefGoogle ScholarPubMed
Cullen, B, Watt, PW, Lundqvist, C, Silcock, D, Schmidt, RJ, Bogan, D, et al. The role of oxidised regenerated cellulose/collagen in chronic wound repair and its potential mechanism of action. Int J Biochem Cell Biol 2002;34:1544–56CrossRefGoogle ScholarPubMed
Angel, MF, Zhang, F, Rogers, B, Caplan, J, Dorsett-Martin, W, Blain, B, et al. Role of free radicals in necrosis of skin graft compromised with hematoma. Ann Plast Surg 2002;48:665–9CrossRefGoogle ScholarPubMed
Hart, J, Silcock, D, Gunnigle, S, Cullen, B, Light, ND, Watt, PW. The role of oxidised regenerated cellulose/collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557–70CrossRefGoogle Scholar
Jeschke, MG, Sandmann, G, Schubert, T, Klein, D. Effect of oxidized regenerated cellulose/collagen matrix on dermal and epidermal healing and growth factors in an acute wound. Wound Repair Regen 2005;13:324–31CrossRefGoogle Scholar