Hostname: page-component-6766d58669-kl59c Total loading time: 0 Render date: 2026-05-21T04:00:21.717Z Has data issue: false hasContentIssue false
  • English
  • Français

Post-radiation primary intranodal leiomyosarcoma

Published online by Cambridge University Press:  29 June 2007

Hiroaki Fujii ,
Leon Barnes ,
Jonas T. Johnson  and
Silloo B. Kapadia
Hiroaki Fujii
Affiliation:
Departments of Pathology, Presbyterian University Hospital, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582.
Leon Barnes
Affiliation:
Departments of Pathology, Presbyterian University Hospital, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582.
Jonas T. Johnson
Affiliation:
Departments of Otolaryngology, The Eye and Ear Institute, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582.
Silloo B. Kapadia*
Affiliation:
Departments of Pathology, Presbyterian University Hospital, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582.
*
Address for correspondence: Silloo B. Kapadia, M.D., Department of Pathology, Presbyterian University Hospital, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA.
Get access Rights & Permissions [Opens in a new window]

Abstract

An unusual case of post-radiation primary intranodal leiomyosarcoma of the cervical lymph node is presented. The patient was a 32-year-old white man who was treated in 1986 with hemiglossectomy and right neck dissection, followed by radiation therapy, for squamous cell carcinoma of the tongue. Six years later, he presented with an enlarged left cervical lymph node which on biopsy showed a high grade spindle cell malignant neoplasm. Immunohistochemistry and electron microscopic study verified the smooth muscle origin of the tumour.

Extensive work-up for a second primary lesion was negative. Primary intranodal leiomyosarcoma is extremely rare. We briefly discuss the histological differential diagnosis of spindle cell lesions of lymph nodes, leiomyosarcoma of the vessel wall and radiation-associated sarcoma.

Keywords

LeiomyosarcomaLymph nodesNeckRadiotherapy, complicationsCarcinoma, squamous cellTongue

Information

Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 1 , January 1995 , pp. 80 - 83
Copyright
Copyright © JLO (1984) Limited 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

Footnotes

Supported by the Pathology Education and Research Foundation, Department of Pathology, University of Pittsburgh School of Medicine.

References

Amendola, B. E., Amendola, M. A., McClatchey, K. D., Miller, C. H. Jr. (1989) Radiation-associated sarcoma: a review of 23 patients with post-radiation sarcoma over a 50-year period. American Journal of Clinical Oncology 12: 411–415.CrossRefGoogle Scholar
Berman, M. A., Nalesnik, M. A., Kapadia, S. B., Rinaldo, C. R., Jensen, F. (1986) Primary lymphadenopathic Kaposi's sarcoma in an immunocompetent 23-year-old man. American Journal of Clinical Pathology 86: 366–369.CrossRefGoogle Scholar
Chen, K. T. K. (1992) Mycobacterial spindle cell pseudotumor of lymph nodes. American Journal of Surgical Pathology 16: 276–281.CrossRefGoogle ScholarPubMed
Fletcher, C. D., Stirling, R. W. (1990) Intranodal myofibroblastoma presenting in the submandibular region: evidence of a broader clinical and histological spectrum. Histopathology 16: 287–294.CrossRefGoogle ScholarPubMed
Fong, Y., Coit, D. G., Woodruff, J. M., Brennan, M. F. (1993) Lymph node metastasis from soft tissue sarcoma in adults. Analysis of data from a prospective database of 1772 sarcoma patients. Annals of Surgery 217: 72–77.CrossRefGoogle ScholarPubMed
Lee, J. Y., Abell, E., Shevechik, G. J. (1989) Solitary spindle cell tumor with myoid differentiation of the lymph node. Archives of Pathology and Laboratory Medicine 113: 547–550.Google ScholarPubMed
Nakhleh, R. E., Zarbo, R. J., Ewing, S., Carey, J. L., Gown, A. M. (1993) Myogenic differentiation in spindle cell (sarcomatoid) carcinomas of the upper aerodigestive tract. Applied Immunohistochemistry 1: 58–68.Google Scholar
Starasoler, L., Vuitch, E, Albores-Saavedra, J. (1991) Intranodal leiomyoma. Another distinctive primary spindle cell neoplasm of lymph node. American Journal of Clinical Pathology 95: 858–862.CrossRefGoogle ScholarPubMed
Suster, S., Rosai, J. (1989) Intranodal hemorrhagic spindle-cell tumor with 'amianthoid' fibers. Report of six cases of a distinctive mesenchymal neoplasm of the inguinal region that simulates Kaposi's sarcoma. American Journal of Surgical Pathology 13: 347–357.CrossRefGoogle ScholarPubMed
Weiss, K. S., Zidar, B. L., Wang, S., Magovern, G. J., Raju, R. N., Lupetin, A. R., Shackney, S. E., Simon, S. R., Singh, M., Pugh, R. P. (1987) Radiation-induced leiomyosarcoma of the great vessels presenting as superior vena cava syndrome. Cancer 60: 1238–1242.3.0.CO;2-V>CrossRefGoogle ScholarPubMed
Weiss, S. W, Gnepp, D. R., Bratthauser, G. L. (1989) Palisaded myofibroblastoma. A benign mesenchymal tumor of lymph node. American Journal of Surgical Pathology 13: 341–346.CrossRefGoogle ScholarPubMed
Weiss, L. M., Berry, G. J., Dorfman, R. E, Banks, P., Kaiserling, E., Curtis, J., Rosai, J., Warnke, R. A. (1990) Spindle cell neoplasms of lymph nodes of probable reticulum cell lineage. True reticulum cell sarcoma? American Journal of Surgical Pathology 14: 405–414.CrossRefGoogle Scholar
Wiklund, T. A., Blomqvist, C. P., Raty, J., Elomaa, I., Rissanen, P., Miettinen, M. (1991) Postirradiation sarcoma. Analysis of a nationwide cancer registry material. Cancer 68: 245–531.3.0.CO;2-E>CrossRefGoogle ScholarPubMed