Hostname: page-component-8448b6f56d-c4f8m Total loading time: 0 Render date: 2024-04-19T06:51:38.853Z Has data issue: false hasContentIssue false
  • English
  • Français

Acute labyrinthitis associated with systemic Candida albicans infection in ageing mice

Published online by Cambridge University Press:  29 June 2007

Robert B. Ashman ,
John M. Papadimitriou  and
Alma Fulurija
Robert B. Ashman*
Affiliation:
Department of Pathology, University of Western Australia, Nedlands, WA. 6009. Australia
John M. Papadimitriou
Affiliation:
Department of Pathology, University of Western Australia, Nedlands, WA. 6009. Australia
Alma Fulurija
Affiliation:
Department of Pathology, University of Western Australia, Nedlands, WA. 6009. Australia
*
Address for correspondence: Dr R. B. Ashman, Department of Pathology, University of Western Australia, Nedlands, W.A. 6009. Australia. Fax: 61 9 346 2891
Get access Rights & Permissions [Opens in a new window]

Abstract

The yeast Candida albicans is an important opportunistic pathogen that has been associated with disease of the inner ear. This study describes the histopathology of acute labyrinthitis caused by systemic infection with C. albicans in ageing inbred mice. Within four days after infection, yeast and hyphal forms of C. albicans were found in the membranous labyrinth. The utricle and the adjacent parts of the ampullary regions of the semicircular canals were most severely affected, but damage was also seen in the scala media, the Scala tympani, the saccule, and the scala vestibuli. In the utricle, the lining epithelium of the membranous labyrinth was disrupted, and the lining cells of the vestibular membrane showed foci in which the membrane was disrupted. The data suggest that age may represent a risk factor for fungal labyrinthitis.

Keywords

Candida a1bican LabyrinthitisAgeing
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 1 , January 1996 , pp. 13 - 18
Copyright
Copyright © JLO (1984) Limited 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ashman, R. B. (1982) Persistence of cell-mediated immunity to influenza A virus in mice. Immunology 47: 165–168.Google ScholarPubMed
Ashman, R. B., Papadimitriou, J. M. (1987) Murine candidiasis. Pathogenesis and host responses in genetically distinct inbred mice. Immunolbgy and Cell Biology 65: 163–171.CrossRefGoogle ScholarPubMed
Ashman, R. B., Papadimitriou, J. M. (1989) Genetic regulation of pathogenesis and host responses in fungal infection. In Immunology of Fungal Infection (Kurstak, E., Marquis, G., eds.), Marcel Dekker, New York, pp 347–371.Google ScholarPubMed
Ashman, R. B., Papadimitriou, J. M. (1990) What's new in the mechanisms of host resistance to Candida albicans infection? Pathology Research and Practice 186: 527–534.CrossRefGoogle ScholarPubMed
Ashman, R. B., Papadimitriou, J. M. (1991) Chronic osteomyelitis as a consequence of systemic Candida albicans infection. Immunology and Cell Biology 69: 427–429.CrossRefGoogle ScholarPubMed
Bergestrom, L., Hemenway, W., Barnhart, R. (1970) Rhino-cerebral and otologic mucormycosis. Annals of Otology, Rhinology and Laryngology 79: 70–81.CrossRefGoogle Scholar
Bhatt, S., Halpin, C., Hsu, W., Thedinger, B. A., Levine, R. A., Tuomanen, E., Nadol, J. B. Jr (1991) Hearing loss and pneumococcal meningitis: an animal model. Laryngoscope 101: 1285–1292.CrossRefGoogle ScholarPubMed
Blank, A. L., Davis, G. J., Van De Water, T. R., Ruben, R. J. (1994) Acute Streptococcus pneumoniae meningogenic labyrinthitis. An experimental guinea pig model and literature review. Archives of Otolaryngology–Head and Neck Surgery 120: 1342–1346.Google Scholar
Bodey, G. P. (1966) Fungal infections complicating acute leukemia. Journal of Chronic Disease 19: 667–687.Google Scholar
Fukuda, S., Ishikawa, K., Inuyama, Y. (1994) Acute measles infection in hamster cochlea. Acta Oto-Laryngologica (suppl) 514: 111–116.Google Scholar
Gussen, R., Canalis, R. (1982) Muco-mycosis of the temporal bone. Annals of Otology, Rhinology and Laryngology 91: 27–32.CrossRefGoogle ScholarPubMed
Hanna, E., Hughes, G., Eliachar, I., Wanamaker, J., Tomford, W. (1993) Fungal osteomyelitis of the temporal bone: a review of reported cases. Ear, Nose, and Throat Journal 72: 537–541.Google Scholar
Kim, M. H., Rodey, G. E., Good, R. A., Chilgren, R. A., Quie, P. G. (1969) Defective candidacidal capacity of polymorphonuclear leukocytes in chronic granulomatous disease of childhood. Journal of Pediatrics 75: 300–303.Google Scholar
Lehrer, R. I., Cline, M. J. (1971) Leukocyte candidacidal activity and resistance to systemic candidiasis in patients with cancer. Cancer 27: 1211–1217.3.0.CO;2-3>CrossRefGoogle ScholarPubMed
Louis, T. III, Lockey, M. (1974) Blastomycosis of the middle ear. Southern Medical Journal 67: 1489–1491.CrossRefGoogle ScholarPubMed
McGill, T. J. (1978) Mycotic infection of the temporal bone. Archives of Otolaryngology – Head and Neck Surgery 104: 140–144.CrossRefGoogle ScholarPubMed
Meyerhoff, W. L., Paparella, M. M., Oda, M., Shea, D. (1979) Mycotic infections of the inner ear. Laryngoscope 89: 1725–1734.CrossRefGoogle ScholarPubMed
Papadimitriou, J. M., Ashman, R. B. (1986) The pathogenesis of acute systemic candidiasis in a susceptible inbred mouse strain. Journal of Pathology 150: 257–265.CrossRefGoogle Scholar
Rarey, K. E., Davis, L. E. (1993) Temporal bone histopathology 14 years after cytomegalic inclusion disease: a case study. Laryngoscope 103: 904–909.Google Scholar
Wade, J. C. (1993) Epidemiology of Candida infections. In Candidiasis. Patho genesis, Diagnosis, and Treatment. 2nd Edition. (Bodey, G. P., ed.) Raven Press, New York, pp. 85–107.Google Scholar