Allostasis, Homeostasis, and the Costs of Physiological Adaptation

doi:10.1017/CBO9781316257081

The concept of homeostasis, the maintenance of the internal physiological environment of an organism within tolerable limits, is well established in medicine and physiology. In contrast, allostasis is a relatively new idea of 'viability through change'. With allostatic regulation by cephalic involvement, the body adapts to potentially diverse and dangerous situations through the activation of neural, hormonal, or immunological mechanisms. Allostasis explains how regulatory events maintain organismic viability, or not, in diverse contexts with varying set points of bodily needs and competing motivations. This 2005 book introduces the concept of allostasis and sets it alongside traditional views of homeostasis. It addresses basic regulatory systems and examines the behavior of bodily regulation under duress. The basic concepts of physiological homeostasis are integrated with disorders like depression, stress, anxiety and addiction. It will therefore appeal to graduate students, medical students and researchers working in physiology, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology.

Review of the hardback:'This book … is very welcome as it goes a good way towards introducing readers of all levels to the concept … it is well balanced … this book will be an important text for those who want to know more.'

Source: Biologist

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Contents

Frontmatter
pp i-iv
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Dedication
pp v-vi
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Contents
pp vii-viii
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Preface
pp ix-x
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Contributors
pp xi-xii
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Introduction
pp 1-16
- By Jay Schulkin, Georgetown University
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1 - Principles of Allostasis: Optimal Design, Predictive Regulation, Pathophysiology, and Rational Therapeutics
pp 17-64
- By Peter Sterling, University of Pennsylvania
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2 - Protective and Damaging Effects of the Mediators of Stress and Adaptation: Allostasis and Allostatic Load
pp 65-98
- By Bruce S. McEwen, The Rockefeller University
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3 - Merging of the Homeostat Theory with the Concept of Allostatic Load
pp 99-112
- By David S. Goldstein, National Institute of Neurological Disorders and Stroke
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4 - Operationalizing Allostatic Load
pp 113-149
- By Burton Singer, Princeton University, Carol D. Ryff, University of Wisconsin, Teresa Seeman, University of California, Los Angeles
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5 - Drug Addiction and Allostasis
pp 150-163
- By George F. Koob, The Scripps Research Institute, Michel Le Moal, Institut National de la Sante et de la Recherche Medicale
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6 - Adaptive Fear, Allostasis, and the Pathology of Anxiety and Depression
pp 164-227
- By Jeffrey B. Rosen, University of Delaware, Jay Schulkin, Georgetown University
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7 - A Chronobiological Perspective on Allostasis and Its Application to Shift Work
pp 228-301
- By Ziad Boulos, Columbia University, Alan M. Rosenwasser, University of Maine
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8 - Allostatic Load and Life Cycles: Implications for Neuroendocrine Control Mechanisms
pp 302-342
- By John C. Wingfield, University of Washington
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Commentary: Viability as Opposed to Stability: An Evolutionary Perspective on Physiological Regulation
pp 343-364
- By Michael L. Power, none
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Index
pp 365-372
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Allostasis, Homeostasis, and the Costs of Physiological Adaptation

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Contents

Frontmatter
pp i-iv

Dedication
pp v-vi

Contents
pp vii-viii

Preface
pp ix-x

Contributors
pp xi-xii

Introduction
pp 1-16

1 - Principles of Allostasis: Optimal Design, Predictive Regulation, Pathophysiology, and Rational Therapeutics
pp 17-64

2 - Protective and Damaging Effects of the Mediators of Stress and Adaptation: Allostasis and Allostatic Load
pp 65-98

3 - Merging of the Homeostat Theory with the Concept of Allostatic Load
pp 99-112

4 - Operationalizing Allostatic Load
pp 113-149

5 - Drug Addiction and Allostasis
pp 150-163

6 - Adaptive Fear, Allostasis, and the Pathology of Anxiety and Depression
pp 164-227

7 - A Chronobiological Perspective on Allostasis and Its Application to Shift Work
pp 228-301

8 - Allostatic Load and Life Cycles: Implications for Neuroendocrine Control Mechanisms
pp 302-342

Commentary: Viability as Opposed to Stability: An Evolutionary Perspective on Physiological Regulation
pp 343-364

Index
pp 365-372

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Allostasis, Homeostasis, and the Costs of Physiological Adaptation

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