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A non-homogeneous alternating renewal process model for interval censoring

Published online by Cambridge University Press:  16 September 2024

M. N. M. van Lieshout*
Affiliation:
CWI, University of Twente
R. L. Markwitz*
Affiliation:
CWI, University of Twente
*
*Postal address: Stochastics Research Group, Centrum Wiskunde & Informatica (CWI), P.O. Box 94079, NL-1090 GB Amsterdam, The Netherlands. Email: Marie-Colette.van.Lieshout@cwi.nl
**Postal address: Department of Applied Mathematics, University of Twente, P.O. Box 217, NL-7500 AE, Enschede, The Netherlands.
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Abstract

Previous approaches to modelling interval-censored data have often relied on assumptions of homogeneity in the sense that the censoring mechanism, the underlying distribution of occurrence times, or both, are assumed to be time-invariant. In this work, we introduce a model which allows for non-homogeneous behaviour in both cases. In particular, we outline a censoring mechanism based on a non-homogeneous alternating renewal process in which interval generation is assumed to be time-dependent, and we propose a Markov point process model for the underlying occurrence time distribution. We prove the existence of this process and derive the conditional distribution of the occurrence times given the intervals. We provide a framework within which the process can be accurately modelled, and subsequently compare our model to the homogeneous approach through a number of illustrative examples.

Information

Type
Original Article
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of Applied Probability Trust
Figure 0

Figure 1. Visualisation of a non-homogeneous alternating renewal process with initial values $S_0 = 1$ and $X_0 = 0$. At the dotted line, one cycle has passed – i.e. the process has taken both possible state values. The jump times correspond to a change of state. Since t falls in state 1, a non-zero age A(t) and excess B(t) are recorded. If t were to fall in state 0, an exact time would be recorded.

Figure 1

Figure 2. The unbroken line corresponds to the actual probability density of interval length for $k=1$ and $\lambda(0.6;\ 1) = 1$. The dotted line corresponds to the estimated survival time density.

Figure 2

Figure 3. Probability density function of the starting time $f_x({\cdot})$ with $x=1$ for various choices of $g_Y$ and m.

Figure 3

Figure 4. A comparison between a regular and clustered model with a ‘peak time’ added by changing the intensity function within a critical range.