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Combined therapy in advanced head and neck cancers

Published online by Cambridge University Press:  29 June 2007

Sudhir Bahadur ,
Subirendra Kumar ,
D. A. Tandon ,
G. K. Rath  and
Sudarsan De
Sudhir Bahadur*
Affiliation:
New Delhi, India
Subirendra Kumar
Affiliation:
New Delhi, India
D. A. Tandon
Affiliation:
New Delhi, India
G. K. Rath
Affiliation:
New Delhi, India
Sudarsan De
Affiliation:
New Delhi, India
*
Dr Sudhir Bahadur, Department of Otolaryngology, All India Institute of Medical Sciences, New Delhi–110029, India.
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Abstract

The results of single modality treatment using surgery or radiotherapy alone in advanced head and neck cancers are known to be unsatisfactory. The present study analyses 252 cases with stage III and IV resectable cancers of the head and neck region selected to be treated by a combined regime of pre- or post-operative radiation and radical surgery. Only 193 patients completed the treatment protocol. There were 58 cases (33.5 per cent) who failed either at primary or regional sites or both. Nine cases (five per cent) developed distant metastasis. Absolute and determinate four year disease-free survival was 55 per cent and 61 per cent respectively. Early lesions (stage I and II) have been excluded from the study. The study indicates that a reduction in primary and regional failures correlates well with a combined therapy, though prolonged treatment may affect patients' compliance to some extent.

Keywords

Neoplasmshead and neckCombined modality therapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 5 , May 1992 , pp. 412 - 415
Copyright
Copyright © JLO (1984) Limited 1992

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References

Bahadur, S., Kacker, S. K. (1985) Surgery for pyriform fossa cancer. Indian Journal of Otolaryngology, 37: 83–84.CrossRefGoogle Scholar
Bahadur, S., Iyer, S. (1985) Results of surgery in advanced carcinoma of the larynx. Indian Journal of Otolaryngology, 37: 131–134.CrossRefGoogle Scholar
Bahadur, S., Rath, G. K., De, S., Chaudhary, A. D., Tandon, D. A. (1987) Failure at primary and regional sites following combined treatment in advanced head and neck cancer. Indian Journal of Cancer, 24: 36–40.Google Scholar
Bartelink, H., Breur, K., Hart, G. (1982) Radiotherapy of lymph node metastasis in patients with squamous cell carcinoma of the head and neck region. International Journal of Radiation Oncology, Biology and Physics, 8: 983–989.CrossRefGoogle ScholarPubMed
Bataini, P., Brugere, J., Bernier, J., Jaulerry, C. H., Picot, C., Ghossein, N. A. (1982) Results of radical radiotherapeutic treatment of carcinoma of the pyriform sinus—experience of the Institute Curie. International Journal of Radiation, Oncology, Biology and Physics, 8: 1277–1286.CrossRefGoogle Scholar
Becker, S. P., Atiyah, R. A. (1985) Nasal and paranasal malignancies. Otolaryngologic Clinics of North America, 18: 491–497.CrossRefGoogle ScholarPubMed
Bryce, D. P. (1984) In Current Theory of Otolaryngology—Head and Neck Surgery [Gates, G. A., Ed.] B. C. Decker: Philadelphia.Google Scholar
Cachin, V., Eschwege, F. (1975) Combination of radiotherapy and surgery in the treatment of head and neck cancer. Cancer Treatment Reviews, 2: 177–191.CrossRefGoogle Scholar
Collins, S. L. (1987) Controversies in management of cancer of the neck. In Comprehensive Management of Head and Neck Tumours. [Thawley, S. E., Panje, W. R., Eds.] W. B. Saunders Company: Philadelphia, p. 1386–1443.Google Scholar
Constable, W. C., Marks, R. D., Robbins, J. P., Fitz Hugh, G. S. (1972) High dose preoperative radiotherapy and surgery for cancer of the larynx. Laryngoscope, 82: 1861–1868.CrossRefGoogle ScholarPubMed
El Badawi, S. A., Goepfert, H., Fletcher, G. H., Herson, J., Oswald, M. J. (1982) Squamous cell carcinoma of the pyriform sinus. Laryngoscope, 92: 357–364.CrossRefGoogle ScholarPubMed
Farr, H. W., Arthur, K. (1972) Epidermoid carcinoma of the mouth and pharynx. Journal of Laryngology and Otology, 86: 243–253.CrossRefGoogle ScholarPubMed
Fletcher, G. H. (1980) Combination of irradiation and surgery. Text book of Radiotherapy, 3rd edition. Lea and Febiger: Philadelphia, p. 219–224.Google Scholar
Goldman, J. L., Silverstone, S. M., Roffman, J. D., Birken, E. A. (1972) High dose preoperative radiation and surgery for carcinome of the larynx and hypopharynx. Laryngoscope, 82: 1869–1882.CrossRefGoogle Scholar
Jesse, R. H., Lindberg, R. D. (1975) The efficacy of combining radiation therapy with a surgical procedure in patients with a cervical metastasis from squamous cancer of the hypopharynx and oropharynx. Cancer, 35: 1163–1166.3.0.CO;2-C>CrossRefGoogle ScholarPubMed
Kalavathi, N. (1970) Factors influencing cure in the radiotherapy of postcricoid carcinoma. Clinical Radiology, 21: 248–252.CrossRefGoogle Scholar
Rammuler, D., Medina, J. E., Byers, R. M. (1985) Treatment of choice for squamous cancer of tonsillar fossa. Head and Neck Surgery, 7: 206–209.CrossRefGoogle Scholar
Rolander, T. L., Everts, E. C., Shumrick, D. A. (1971) Carcinoma of the tonsil; a planned combined therapy approach. Laryngoscope, 81: 1199–1207.CrossRefGoogle ScholarPubMed
Schuller, D. E., Laramore, G., Al-Sarraf, M., Jacob, J., Pajak, T. F. (1989) Combined therapy for resectable head and neck cancer. Archives of Otolaryngology and Head and Neck Surgery, 115: 364–368.CrossRefGoogle ScholarPubMed
Shapshay, S. M., Hybels, R. L. (1985) Treatment of cancer of the larynx. Otolaryngologic Clinics of North America, 18: 461–468.CrossRefGoogle ScholarPubMed
Snow, J. B., Gelber, R. D., Kramer, S., Davis, L. W., Marcial, V. A., Lowry, L. D. (1981) Comparison of preoperative and postoperative radiation therapy for patients with carcinoma of the Head and Neck. Acta Otolaryngologica, 91: 611–626.CrossRefGoogle ScholarPubMed
Strong, E. W. (1969) Preoperative radiation and neck dissection. Surgical Clinics of North America, 49: 271–276.CrossRefGoogle ScholarPubMed
Thawley, S. E., Simpson, J. R., Marks, J. E., Perez, C. A., Ogura, J. H. (1983) Preoperative irradiation and surgery for carcinoma of the base of tongue. Annals of Otology, Rhinology and Laryngology, 92: 485–490.CrossRefGoogle Scholar
Vikram, B., Farr, H. W. (1983) Adjuvant irradiation therapy in locally advanced head and neck cancer. Cancer, 33: 134–138.Google ScholarPubMed
Vikram, B. (1984) Changing patterns of failure in advanced head and neck cancer. Archives of Otolaryngology, 110: 564–565.CrossRefGoogle ScholarPubMed
Wang, C. C., Schultz, M. D., Miller, D. (1972) Combined radiation therapy and surgery for carcinoma of supraglottis and pyriform sinus. Laryngoscope, 82: 1883–1890.CrossRefGoogle ScholarPubMed