Hostname: page-component-8448b6f56d-t5pn6 Total loading time: 0 Render date: 2024-04-25T01:52:48.853Z Has data issue: false hasContentIssue false
  • English
  • Français

A controlled study of the suppression of tinnitus by lidocaine infusion: (Relationship of therapeutic effect with serum lidocaine levels)

Published online by Cambridge University Press:  29 June 2007

E. Perucca  and
P. Jackson
Get access Rights & Permissions [Opens in a new window]

Summary

The relationship between serum lidocaine levels and tinnitus relief was assessed in 5 patients during intermittent intravenous infusions of the drug. Experiments were conducted under controlled conditions in that neither the attending physician nor the patient was aware of whether active drug or placebo was being infused at any particular time. A significant relationship between serum level and effect was observed in two patients. In the remaining patients this relationship was not readily apparent but there was still a trent for a better response to be seen at higher levels. A satisfactory response was generally seen at levels above 1 μg/m1. The results are consistent with the hypothesis that the transient nature of the symptomatic relief caused by lidocaine is related ot the fast clearance of the drug from the body.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 99 , Issue 7 , July 1985 , pp. 657 - 661
Copyright
Copyright © JLO (1984) Limited 1985

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Benowitz, N. L. and Meister, W. (1978) Clinical pharmacokinetics of lignocaine. Clinical Pharmacokinetics, 3: 177–201.CrossRefGoogle ScholarPubMed
Gejrot, T. (1976) Intravenous xylocaine in treatment of attacks of Meniére's disease. Acta Otolaryngologica, 82: 301–302.Google Scholar
Martin, F. W. and Colman, B. H. (1980) Tinnitus: a double-blind crossover trial to evaluate the use of lignocaine. Clinical Otolaryngology, 5: 3–11.Google Scholar
Melding, P. S., Goodey, R. J. and Thorne, P. R. (1978) The use of intravenous lignocaine in the diagnosis and treatment of tinnitus. Journal of Laryngology and Otology, 92: 115–121.CrossRefGoogle ScholarPubMed
Perucca, E. and Richens, A. (1979) Reduction of oral availability of lignocaine by induction of first-pass metabolism in epileptic patients. British Journal of Clinical Pharmacology, 8: 1–31.CrossRefGoogle ScholarPubMed
Sakata, E., Umeda, Y., Takahashi, K. and Ohtsu, K. (1976) Treatment of cochlear tinnitus—Blocking therapy with 4 per cent lidocaine. Journal of Otolaryngology of Japan, 9: 741–746.Google Scholar