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Lactate dehydrogenase in human maxillary adenocarcinoma and in experimental adenocarcinoma in mice

Published online by Cambridge University Press:  29 June 2007

Wiesław Gołabek  and
Leonard M. Franks
Wiesław Gołabek
Affiliation:
Department of Otolaryngology, Academy of Medicine, Lublin, Poland
Leonard M. Franks*
Affiliation:
Department of Cellular Pathology, Imperial cancer Research Fund, Lincoln' UK
*
L. M. Franks, M. D., Senior Consulting Scientist, Imperial Cancer Research Fund Laboratories, P.O. Box No. 123, Lincoln's Inn Fields, London WC2A 3PX
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Abstract

Total lactate dehydrogenase (LDH) activity and isoenzyme pattern were studied in tumore tissue from eight patients with maxillary adenocarcinoma, chronic inflammatory mucosa from 12 patients, normal maxillary mucosa from 12 patients, and an experimental lung adenocarcinoma and normal lung tissue from 12 mice.

An increase in the total LDH activity and cathodic shift in LDH isoenzyme pattern was found in human maxillary adenocarcinoma as compared to normal and inflammatory mucosa. The inflammatory mucosa showed an increase in the total LDH activity and a normal isoenzyme pattern. The LDH alterations in the total LDH activity and a normal isoenzyme pattern. The LDH alterations in the experimental lung adenocarcinoma in mice were similar to those in the human tumours but they were much more marked.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 99 , Issue 2 , February 1985 , pp. 171 - 175
Copyright
Copyright © JLO (1984) Limited 1985

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