Hostname: page-component-6766d58669-6mz5d Total loading time: 0 Render date: 2026-05-16T13:48:02.298Z Has data issue: false hasContentIssue false
  • English
  • Français

Stage is a prognostic factor for surgically treated patients with early-stage lip cancer for whom a ‘wait and see’ policy in terms of neck status has been implemented

Published online by Cambridge University Press:  15 August 2017

G Eskiizmir ,
E Ozgur ,
G Karaca ,
P Temiz ,
N Hacioglu Yanar  and
B Cengiz Ozyurt
G Eskiizmir
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Celal Bayar University, Manisa, Turkey
E Ozgur*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery Clinic, Bigadic State Hospital, Balikesir, Turkey
G Karaca
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Celal Bayar University, Manisa, Turkey
P Temiz
Affiliation:
Department of Pathology, Celal Bayar University, Manisa, Turkey
N Hacioglu Yanar
Affiliation:
Department of Otolaryngology – Head and Neck Surgery Clinic, Manisa State Hospital, Manisa, Turkey
B Cengiz Ozyurt
Affiliation:
Department of Public Health, Celal Bayar University, Manisa, Turkey
*
Address for correspondence: Dr Erdoğan Ozgur, Çavuş Gazi Blv. No: 4, 10440 Bigadiç, Balıkesir, Turkey Fax: +90 2666 141 417 E-mail: drerdoganozgur@gmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objectives:

To determine the locoregional control and survival rates (in terms of risk factors) of patients who underwent surgical resection of early-stage lip cancer and for whom a ‘wait and see’ policy in terms of neck status had been implemented.

Methods:

The sociodemographic data, tumour stage, tumour characteristics and histopathological features of 41 patients with early-stage lip cancer were evaluated. Factors predictive of survival and locoregional recurrence were analysed. The five-year overall survival and disease-free survival rates were determined, and the prognostic risk factors were compared.

Results:

The mean follow-up period was 60.5 months (range, 4–92 months). Age, sex, tumour stage, tumour thickness and volume, and perineural involvement were not predictive of locoregional recurrence or survival. Pathological tumour stage (T1 vs T2) was a prognostic factor for both five-year overall survival (87.3 vs 65.6 per cent, p = 0.042) and disease-free survival (88.6 vs 65.6 per cent, p = 0.037).

Conclusion:

Tumour stage was clearly a major factor affecting the prognosis of surgically treated patients with early-stage lip cancer for whom a ‘wait and see’ policy in terms of neck status had been implemented.

Keywords

Lip NeoplasmsCarcinoma, Squamous CellHead And Neck NeoplasmsLocal Neoplasm RecurrencePrognosisSurvivalDisease-Free Survival

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Issue 10 , October 2017 , pp. 889 - 894
Copyright
Copyright © JLO (1984) Limited 2017 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

Footnotes

Presented at the 7th European Congress on Head and Neck Oncology, 7–10 September 2016, Budapest, Hungary.

References

1 Vukadinovic, M, Jezdic, Z, Petrovic, M, Medenica, LM, Lens, M. Surgical management of squamous cell carcinoma of the lip: analysis of a 10-year experience in 223 patients. J Oral Maxillofac Surg 2007;65:675–9Google Scholar
2 Abreu, L, Kruger, E, Tennant, M. Lip cancer in Western Australia, 1982–2006: a 25-year retrospective epidemiological study. Aust Dent J 2009;54:130–5Google Scholar
3 Czerninski, R, Zini, A, Sgan-Cohen, HD. Lip cancer: incidence, trends, histology and survival: 1970–2006. Br J Dermatol 2010;162:1103–9Google Scholar
4 Luna-Ortiz, K, Guemes-Meza, A, Villavicencio-Valencia, V, Mosqueda-Taylor, A. Lip cancer experience in Mexico. An 11-year retrospective study. Oral Oncol 2004;40:992–9Google Scholar
5 Salgarelli, AC, Sartorelli, F, Cangiano, A, Pagani, R, Collini, M. Surgical treatment of lip cancer: our experience with 106 cases. J Oral Maxillofac Surg 2009;67:840–5Google Scholar
6 Zitsch, RP 3rd. Carcinoma of the lip. Otolaryngol Clin North Am 1993;26:265–77Google Scholar
7 Cerezo, L, Liu, FF, Tsang, R, Payne, D. Squamous cell carcinoma of the lip: analysis of the Princess Margaret Hospital experience. Radiother Oncol 1993;28:142–7CrossRefGoogle ScholarPubMed
8 Galyon, SW, Frodel, JL. Lip and perioral defects. Otolaryngol Clin North Am 2001;34:647–66Google Scholar
9 Grant, WB. Role of solar UVB irradiance and smoking in cancer as inferred from cancer incidence rates by occupation in Nordic countries. Dermatoendocrinol 2012;4:203–11Google Scholar
10 Shah, JP, Patel, SG, Singh, B. Jatin Shah's Head and Neck Surgery and Oncology. Philadelphia: Elsevier, 2012 Google Scholar
11 Head and Neck Cancers NCCN Guidelines. In: https://www.pdf-archive.com/2015/08/30/head-and-neck/head-and-neck.pdf [20 September 2016]Google Scholar
12 Huang, SH, Hwang, D, Lockwood, G, Goldstein, DP, O'Sullivan, B. Predictive value of tumor thickness for cervical lymph-node involvement in squamous cell carcinoma of the oral cavity: a meta-analysis of reported studies. Cancer 2009;115:1489–97Google Scholar
13 Zitsch, RP 3rd, Park, CW, Renner, GJ, Rea, JL. Outcome analysis for lip carcinoma. Otolaryngol Head Neck Surg 1995;113:589–96Google Scholar
14 Cooper, JS, Porter, K, Mallin, K, Hoffman, HT, Weber, RS, Ang, KK et al. National Cancer Database report on cancer of the head and neck: 10-year update. Head Neck 2009;31:748–58Google Scholar
15 Jaquet, Y, Pasche, P, Brossard, E, Monnier, P, Lang, FJ. Meyer's surgical procedure for the treatment of lip carcinoma. Eur Arch Otorhinolaryngol 2005;262:11–16 Google Scholar
16 Bucur, A, Stefanescu, L. Management of patients with squamous cell carcinoma of the lower lip and N0-neck. J Craniomaxillofac Surg 2004;32:16–18 Google Scholar
17 D'Cruz, AK, Vaish, R, Kapre, N, Dandekar, M, Gupta, S, Hawaldar, R et al. Elective versus therapeutic neck dissection in node-negative oral cancer. N Engl J Med 2015;373:521–9Google Scholar
18 Bhandari, K, Wang, DC, Li, SC, Jiang, BH, Guo, YX, Koirala, U et al. Primary cN0 lip squamous cell carcinoma and elective neck dissection: systematic review and meta-analysis. Head Neck 2015;37:1392–400Google Scholar
19 Morselli, P, Masciotra, L, Pinto, V, Zollino, I, Brunelli, G, Carinci, F. Clinical parameters in T1N0M0 lower lip squamous cell carcinoma. J Craniofac Surg 2007;18:1079–82Google Scholar
20 Rena, W, Lia, Y, Liua, C, Qianga, C, Zhang, L, Gaoa, L et al. Surgical management of squamous cell carcinoma of the lower lip: an experience of 109 cases. Med Oral Patol Oral Cir Bucal 2014;19:e398–402 Google Scholar
21 Rodolico, V, Barresi, E, Di Lorenzo, R, Leonardi, V, Napoli, P, Rappa, F et al. Lymph node metastasis in lower lip squamous cell carcinoma in relation to tumour size, histologic variables and p27Kip1 protein expression. Oral Oncol 2004;40:92–8Google Scholar
22 Strieder, L, Coutinho-Camillo, CM, Costa, V, da Cruz Perez, DE, Kowalski, LP, Kaminagakura, E. Comparative analysis of three histologic grading methods for squamous cell carcinoma of the lip. Oral Dis 2017;23:120–5Google Scholar
23 Onerci, M, Yilmaz, T, Gedikoğlu, G. Tumor thickness as a predictor of cervical lymph node metastasis in squamous cell carcinoma of the lower lip. Otolaryngol Head Neck Surg 2000;122:139–42Google Scholar