Hostname: page-component-5db58dd55d-qmkzp Total loading time: 0 Render date: 2026-05-25T18:11:00.977Z Has data issue: false hasContentIssue false
  • English
  • Français

Oncogenic osteomalacia in a patient with an ethmoid sinus tumour

Published online by Cambridge University Press:  11 December 2009

R Kurien ,
M T Manipadam  and
V Rupa
R Kurien
Affiliation:
Department of ENT, Christian Medical College, Vellore, Tamilnadu, India
M T Manipadam
Affiliation:
Department of Pathology, Christian Medical College, Vellore, Tamilnadu, India
V Rupa*
Affiliation:
Department of ENT, Christian Medical College, Vellore, Tamilnadu, India
*
Address for correspondence: Dr V Rupa, Department of ENT, Christian Medical College, Vellore, Tamilnadu, India 632004. Fax: +91 0416 2232035 E-mail: ent3@cmcvellore.ac.in
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

To highlight the clinical presentation and management of a rare case of oncogenic osteomalacia due to an ethmoid sinus tumour.

Materials and methods:

We examined the case records of a 55-year-old man who presented with progressive fatigue, weakness and bone pain, and noted the clinical presentation, laboratory investigations, computed tomography findings, operative notes and follow-up details.

Conclusion:

Oncogenic osteomalacia secondary to a paranasal sinus neoplasm is a rare entity. The causative tumour is often occult and may be missed by routine clinical examination. This case report illustrates the appropriate pattern of evaluation and management to ensure a successful outcome.

Keywords

OsteomalaciaParanasal Sinus NeoplasmsEthmoid Sinuses

Information

Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 7 , July 2010 , pp. 799 - 803
Copyright
Copyright © JLO (1984) Limited 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

1Weidner, N, Santa Cruz, D. Phosphaturic mesenchymal tumors: a polymorphous group causing osteomalacia or rickets. Cancer 1987;59:1442–54Google Scholar
2Koriyama, N, Nishimoto, K, Kodama, T, Nakazaki, M, Kurona, Y, Yoshida, H et al. Oncogenic osteomalacia in a case with a maxillary sinus mesenchymal tumor. Am J Med Sci 2006;332:142–7CrossRefGoogle Scholar
3Weidner, N, Bar, RS, Weiss, D, Strottmann, MP. Neoplastic pathology of oncogenic osteomalacia/rickets. Cancer 1985;55:1691–705Google Scholar
4Folpe, AL, Fanburg-Smith, JC, Billings, SD, Bisceglia, M, Bertoni, F, Cho, JY et al. Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature. Am J Surg Pathol 2004;28:1–30CrossRefGoogle Scholar
5Beech, TJ, Rokade, A, Gittoes, N, Johnson, AP. A haemangiopericytoma of the ethmoid sinus causing oncogenic osteomalacia: a case report and review of the literature. Int J Oral Maxillofac Surg 2007;36:956–8CrossRefGoogle ScholarPubMed
6Fuentealba, C, Pinto, D, Ballesteros, F, Pacheco, D, Boettiger, O, Soto, N et al. Oncogenic hypophosphatemic osteomalacia associated with a nasal hemangiopericytoma. J Clin Rheumatol 2003;9:373–9CrossRefGoogle ScholarPubMed
7Ungari, C, Rocchi, G, Rinna, C, Agrillo, A, Lattanzi, A, Pagnoni, M. Hypophosphaturic mesenchymal tumor of the ethmoid associated with oncogenic osteomalacia. J Craniofac Surg 2004;15:523–7Google Scholar
8Sandhu, FA, Martuza, RL. Craniofacial hemangiopericytoma associated with oncogenic osteomalacia: case report. J Neurooncol 2000;46:241–7CrossRefGoogle ScholarPubMed
9Gonzalez-Compta, X, Mañós-Pujol, M, Foglia-Fernandez, M, Peral, E, Condom, E, Claveguera, T et al. Oncogenic osteomalacia: case report and review of head and neck associated tumours. J Laryngol Otol 1998;112:389–92CrossRefGoogle ScholarPubMed
10Clunie, GPR, Fox, PE, Stamp, TCB. Four cases of acquired hypophosphataemic (‘oncogenic’) osteomalacia. Problems of diagnosis, treatment and long term management. Rheumatology 2000;39:1415–21CrossRefGoogle ScholarPubMed
11Weiss, D, Bar, RS, Weidner, N, Wener, M, Lee, F. Oncogenic osteomalacia: strange tumours in strange places. Postgrad Med J 1985;61:349–55CrossRefGoogle ScholarPubMed
12Ahn, JM, Kim, HJ, Cha, CM, Kim, J, Yim, SG, Kim, HJ. Oncogenic osteomalacia: induced by tumor, cured by surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103:636–41Google Scholar
13Kaylie, DM, Jackson, CG, Gardner, EK. Oncogenic osteomalacia caused by phosphaturic mesenchymal tumor of the temporal bone. Otolaryngol Head Neck Surg 2006;135:653–4Google Scholar
14Schapira, D, Ben Izhak, O, Nachtigal, A, Burstein, A, Shalom, RB, Shagrawi, I et al. Tumor-induced osteomalacia. Semin Arthritis Rheum 1995;25:35–46CrossRefGoogle ScholarPubMed
15Oka, M, Kamo, T, Sasaki, E, Kaji, H, Nishizawa, H, Imanishi, Y et al. A case of phosphaturic mesenchymal tumour (mixed connective tissue variant) that developed in the subcutaneous tissue of a patient with oncogenic osteomalacia and produced fibroblast growth factor 23. Br J Dermatol 2007;157:198–200Google Scholar
16Jacob, JJ, Finny, P, Thomas, M, Thomas, N, John, M. Oncogenic, osteomalacia. J Assoc Physicians India 2007;55:231–3Google Scholar
17Nelson, AE, Mason, RS, Robinson, BG, Hogan, JJ, Martin, EA, Ahlström, H et al. Diagnosis of a patient with oncogenic osteomalacia using a phosphate uptake bioassay of serum and magnetic resonance imaging. Eur J Endocrinol 2001;145:469–76CrossRefGoogle ScholarPubMed
18Casari, S, Rossi, V, Varenna, M, Gasparini, M, Parafioriti, A, Failoni, S et al. A case of oncogenic osteomalacia detected by 111 In- pentetreotide total body scan. Clin Exp Rheumatol 2003;21:493–6Google Scholar
19Harish, S, Jurriaans, E, Jan, E, Sur, M, Colterjohn, N. Giant cell tumour of soft tissue causing oncogenic osteomalacia: report demonstrating the use of octreotide scintigraphy in tumour localization. Clin Radiol 2008;63:101–7Google Scholar
20Chua, SC, O'Connor, SR, Wong, WL, Ganatra, RH. Case report: solitary plasmacytoma of bone with oncogenic osteomalacia: recurrence of tumour confirmed by PET/CT. A case report with a review of the radiological literature. Br J Radiol 2008;8:110–14Google Scholar
21Wenig, BM. Atlas of Head and Neck Pathology: Neoplasms of the Nasal Cavity and Paranasal Sinuses, 2nd edn. New York: Saunders Elsevier, 2008;97–100Google Scholar