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Use of interferon-α in laryngeal papillomatosis: eight years of the Cuban national programme

Published online by Cambridge University Press:  29 June 2007

L. Deuñas ,
V. Alcantud ,
F. Alvarez ,
J. Arteaga ,
A. Benítez ,
M. Bopuza ,
L. Carniege ,
B. Cartaya ,
C. Comas  and
R. Cotayo
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L. Deuñas
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
V. Alcantud
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
F. Alvarez
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
J. Arteaga
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
A. Benítez
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
M. Bopuza
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
L. Carniege
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
B. Cartaya
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
C. Comas
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
R. Cotayo
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
H. Escobar
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
H. Fernández
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
M. Fernández
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
R. Fernández
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
M. García
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
N. Iznaga
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
F. la O
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
J Márquez
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
D. Nordet
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
J. Pérez
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
J. Quintero
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
A. Redonavich
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
M. Robeleco
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
H. Rodríguez
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
P. Ruíz
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
R. Seijas
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
E. Villavicencio
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
D. Viera
Affiliation:
Otorhinolaryngology Services of Hospitals throughout Cuba
F. Damas
Affiliation:
The Ministry of Public Health, Havana, Cuba
P. López-Saura
Affiliation:
Centre for Biological Research, Havana, Cuba
S. Haglund
Affiliation:
Department of Otorhinolaryngology, Stockholm Southern Hospital, Stockholm, Sweden
H. Strander*
Affiliation:
Department of Oncology (Radiumhemmet), Karolinska Hospital, Radiumhemmet, Stockholm, Sweden.
*
Address for correspondence: Hans Strander, M.D., Ass. Professor, Radiumhemmet, Karolinska Hospital, S-17176 Stockholm, Sweden.
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Abstract

Laryngeal papillomatosis is one of the first diseases where interferon (IFN) was found to be effective. In 1983, a programme for the treatment of all such cases started in Cuba. Up to December 1991, 125 patients (92 children, 33 adults) have been treated: 102 with leucocyte IFN-α, 12 with recombinant IFN-α-2b, and 11 have received both preparations. Case management consisted of surgical removal of the lesions followed by an IFN schedule starting with 105 IU/kg of weight in children or 6 × 106 IU in adults, i.m. daily. The dose was progressively reduced, as long as no relapses occurred. At the end of the one-year schedule the doses were reduced to 5 × 104 IU/kg in children or 3 × 106 IU in adults, weekly. If there was a relapse, it was removed surgically and the patient returned to a higher dose level. Most cases (89; 71 per cent) have not relapsed after the treatment; 60 of them have been followed for more than three years. In those with relapses, the frequency of recurrence decreased in all but four patients. The treatment seemed to be more effective if initiated less than three months after the disease onset. The tracheostomy could be removed in five out of seven patients who needed it before the IFN treatment and was necessary in only three new cases during IFN treatment. In two of these, decannulation was possible later on. In a total of 14 patients relapses persisted after several cycles of IFN treatment. They were considered resistant to such treatment. No severe side effects were reported. The most frequent ones were fever, drowsiness, increased bronchial secretion, chills and headache. The establishment of this programme has maintained the disease under control in Cuba.

Keywords

Interferon-αLaryngeal neoplasmsPapilloma

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 111 , Issue 2 , February 1997 , pp. 134 - 140
Copyright
Copyright © JLO (1984) Limited 1997

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