Hostname: page-component-6766d58669-bkrcr Total loading time: 0 Render date: 2026-05-16T21:51:33.045Z Has data issue: false hasContentIssue false
  • English
  • Français

Ototoxicity of ear drops in patients suffering from chronic otitis media*

Published online by Cambridge University Press:  29 June 2007

L. Podoshin ,
M. Fradis  and
J. Ben David
L. Podoshin*
Affiliation:
From the Department of Otolaryngology, Haifa Medical Center (Rothschild), Faculty of Medicine, Tehnion-Israel Institute of Technology, Haifa, Israel.
M. Fradis
Affiliation:
From the Department of Otolaryngology, Haifa Medical Center (Rothschild), Faculty of Medicine, Tehnion-Israel Institute of Technology, Haifa, Israel.
J. Ben David
Affiliation:
From the Department of Otolaryngology, Haifa Medical Center (Rothschild), Faculty of Medicine, Tehnion-Israel Institute of Technology, Haifa, Israel.
*
Correspondence and reprints address: Prof. L. Podoshin, M.D., Dept of Otolaryngology, The Haifa Medical Center (Rothschild), P.O. Box 4940, Haifa 31048, Israel.
Get access Rights & Permissions [Opens in a new window]

Abstract

The sensorineural hearing loss in 150 patients with chronic otitis media who were treated in the Haifa Medical Center (Rothschild) during a ten year period was studied. There were 124 patients treated with a mixture containing neomycin, polymyxin B and dexamethasone and a control group of 26 patients with dexamethasone only.

All patients were followed up for a period of 1–2 years. Patients with hearing loss due to factors such as previous ear surgery, family history, exposure to noise etc., have been excluded.

The conclusions reached were that there is a relationship between the period of disease and the sensorineural hearing loss and that the local treatment with a mixture containing neomycin + polymyxin B appears to contribute to the worsening of the sensorineural hearing loss in patients with chronic otitis media.

Our numbers are small and further studies must be done, but the fact that currently used ear drops may produce a sensorineural hearing loss should not be ignored.

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 103 , Issue 1 , January 1989 , pp. 46 - 50
Copyright
Copyright © JLO (1984) Limited 1989

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

Footnotes

*

Presented at the XI'I World Congress of Otolaryngology, May 1985, Miama Beach, Florida.

References

Belluci, R. J., Fisher, E. G. and Rhodin, J. (1972). Ultra-structure of the round window membrane. Laryngoscope, 82: 1021–1026.CrossRefGoogle Scholar
Dumas, G., Bessord, G., Gavend, M. and Cherachou, R. (1980). Risque de surdite pour instillation de goubte auriculaires couteriant aminosides. Therapie, 35: 357–363.Google Scholar
English, M. G., Northern, J. L. and Fria, T. (1973). Chronic otitis media as a cause of sensorineural hearing loss. Archives of Otolaryngology, 98: 18–22.CrossRefGoogle ScholarPubMed
Fairbanks, D. N. F. (1981). Antimicrobial therapy for chronic suppurative otitis media. Annals of Otology, Rhinology and Laryngology, suppl.58–62.CrossRefGoogle ScholarPubMed
Fradis, M., Ben-David, J., Podoshin, L. and Bashara, B. (1985). Sensorineural hearing loss in chronic otitis media patients treated topically with car drops. New Dimensions in Otolaryngology, Head and Neck Surgery, Vol. 2, p 863–865, Elsevier Science Publishers.Google Scholar
Goycoolea, M. V. (1978). Pathogenesis of otitis media: an experimental study in the cat. Dissertation Abstracts International, 39: 132–210.Google Scholar
Goycoolea, M. V., Paparella, M. M. and Juhn, S. K. (1978). Oval and round window changes in otitis media. Surgery Forum, 29: 578–580.Google ScholarPubMed
Goycoolea, M. V., Paparella, M. M., Goldberg, M. S. and Carpenter, A. M. (1980). Permeability of the round window membrane in otitis media. Archives of Otolaryngology, 106: 430–433.CrossRefGoogle ScholarPubMed
Harada, T., Ikamori, M., Nogai, J. and Nomura, J. (1986) Ototoxicity of neomycin and its penetration through the round window membrane into the perilymph. Annals of Otology, Rhinology and Laryngology, 95: 404–408.CrossRefGoogle ScholarPubMed
Huizing, E. H. (1964). Bone conduction loss due to middle ear pathology: pseudoperceptual deafness. International Audiology, 3: 89, 98–102.CrossRefGoogle Scholar
Hulka, J. H. (1941). Bone conduction changes in acute otitis media. Archives of Otolaryngology, 33: 333–350.CrossRefGoogle Scholar
Kawabala, I. and Paparella, M. M. (1971). Fine structure of round window membrane. Annals of Otology, Rhinology and Laryngology, 80: 13–27.CrossRefGoogle Scholar
Kohonen, A. and Tarkanen, J. (1969). Cochlear damage from ototoxic antibiotics by intratympanic application. Acta Otolaryngologica (Stockholm), 68: 90–97.CrossRefGoogle ScholarPubMed
Murphy, K. W. (1970). Deafness after topical neomycin. British Medical Journal, 2: 114–117.CrossRefGoogle ScholarPubMed
Nomura, J. (1984). Otological significance of the round window. In Pfoltz, C. R. (ed) Advances in Oto-Rhino-Laryngology. Vol. 33, New York, S. Karger, pp. 1–162.Google Scholar
Paparella, M. M., Brady, D. R. and Hoel, R. (1970). Sensorineural hearing loss in chronic otitis media and mastoiditis. Transactions of the American Academy of Ophthalmology and Otolaryngology, 24: 108–115.Google Scholar
Paparella, M. M., Makoto, O., Fumihishe, H. and Brady, D. (1972). Pathology of sensorineural hearing loss in otitis media. Annals of Otology, Rhinology and Laryngology, 81: 632–649.CrossRefGoogle ScholarPubMed
Paparella, M. M., Goycoolea, M. W., Meterhoff, W. L. and Shea, D. (1979). Endolymphatic hydrops and otitis media. Laryngoscope, 89: 43–54.CrossRefGoogle ScholarPubMed
Paparella, M. M. and Shumrick, D. A. (1980). W.B. Saunders Company, vol. II, chapter 15, pp 1422–1444.Google Scholar
Rhodes, T. (1980). Round window membrane permeability to horseradish peroxidase. An electron microscopy study. Thesis, University of Minnisota Graduate School, Minneapolis.Google Scholar
Sakata, E. and Umeda, Y. (1976). Treatment of tinnitus by transtympanic infusion of lidocaine. Auris Nasus Larynx 133–138.CrossRefGoogle Scholar
Schuknecht, H. F. (1957). Ablation therapy in the management of Meniere's disease. Acta Otolaryngologica, Supplement 132: 1–42.Google ScholarPubMed
Shani, R. S., Paparella, M. M., Schadern, P. A., Goycoolea, M. W. and Chep, T. L. (1987). Thickness of the human round window membrane in different forms of otitis media. Archives of Otolaryngology–Head and Neck Surgery, 113: 630–634.CrossRefGoogle Scholar
Smith, B. M. and Myers, M. G. (1978). The penetration of gentamicin and neomycin into perilymph across the round window membrane. Read before the Research Forum of the American Association of Otolaryngology and the Association for Research in Otolaryngology, Las Vegas, Sept. 9.Google Scholar
Stecker, R. H. and Cody, T. R. (1966) Iontophoresis of 22 Na and 131 into the inner ear. Archives of Otolaryngology, 83: 213–217.CrossRefGoogle Scholar
Weinstein, M. J., Oden, E. M., Zeman, W. V. and Wagman, G. H. (1965). Antibiotic absorption after otitis administration in dogs. Antimicrobial Agents Chemotherapy, 5: 239–244.Google Scholar
Wright, C. G., Haloma, A. R. and Meyeroff, W. L. (1987). Ototoxicity of an ototopical preparation in a primate. American Journal of Otology, 8: 56–60.Google ScholarPubMed