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Five of the nine genetically defined regions of mouse t haplotypes are involved in transmission ratio distortion

Published online by Cambridge University Press:  14 April 2009

Lee M. Silver  and
David Remis
Lee M. Silver
Affiliation:
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, U.S.A.
David Remis
Affiliation:
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, U.S.A.
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Mouse t haplotypes have been divided into nine subregions that are each defined by one or more molecular markers. In previous studies, three of these subregions were shown to contain ‘distorter loci’ that interact to effect the transmission-ratio distortion phenotype characteristic of all complete t haplotypes. To determine which of the remaining six subregions also play a role in this phenotype, we analysed the accumulated data on transmission ratio distortion from males that carried one of 26 different combinations of two partial t haplotypes. We have obtained evidence for the association of two additional subregions with distorter loci. First, we present further evidence for the existence of a previously postulated distorter locus, Tcd-3, and describe its mapping to the T66C subregion. Secondly, we describe the identification of a new distorter locus, Tcd-4, in association with the subregion defined by the structural gene for the TCP-1 protein. Further studies indicate that two doses of the Tcd-4 locus are equivalent in effect to a single dose each of Tcd-4 and a second distorter locus, Tcd-1. This result suggests that different distorter locus products could have a common mode of action.

Information

Type
Research Article
Information
Genetics Research , Volume 49 , Issue 1 , February 1987 , pp. 51 - 56
Copyright
Copyright © Cambridge University Press 1987

References

Artzt, K., Shin, H.-S. & Bennett, D. (1982). Gene mapping within the T/t-complex of the mouse. II. Anomalous position of the H-2 complex in t-haplotypes. Cell 28, 471–476.CrossRefGoogle Scholar
Dunn, L. C. & Glücksohn-Wälsch, S. (1951). On the origin and genetic behavior of a new mutation (t3) at a mutable locus in the mouse. Genetics 36, 4–12.CrossRefGoogle Scholar
Fox, H., Silver, L. M. & Martin, G. R. (1984). An alpha globin pseudogene is located within the mouse t complex. Immunogenetics 19, 125–130.CrossRefGoogle ScholarPubMed
Fox, J., Martin, G., Lyon, M. F., Herrmann, B., Frischauf, A.-M., Lehrach, H. & Silver, L. M. (1985). Molecular probes define different regions of the t complex. Cell 40, 63–69.CrossRefGoogle ScholarPubMed
Hammerberg, C. (1981). The influence of T0rl upon male fertility in t-bearing mice. Genelical Research 26, 203–211.CrossRefGoogle Scholar
Herrmann, B., Frischauf, A.-M., Mains, P., Silver, L. M. & Lehrach, H. (1986). Genetic analysis of the proximal portion of the mouse t complex reveals a second inversion within t haplotypes. Cell 44, 469–476.CrossRefGoogle Scholar
Lyon, M. F. (1956). Hereditary hair loss in the tufted mutant of the house mouse. Journal of Heredity 47, 101–103.CrossRefGoogle Scholar
Lyon, M. F. (1984). Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell 37, 621–628.CrossRefGoogle ScholarPubMed
Lyon, M. F. (1986). Male sterility of the mouse t-complex is due to homozygosity of the distorter genes. Cell 44, 357–363.CrossRefGoogle ScholarPubMed
Lyon, M. F. & Mason, I. (1977). Information on the nature of t-haplotypes from the interaction of mutant haplotypes in male fertility and segregation ratio. Genetical Research 29, 255–266.CrossRefGoogle Scholar
Mann, E. A., Silver, L. M. & Elliott, R. W. (1986). Genetic analysis of a mouse t complex locus that is homologous to a kidney cDNA clone. Genetics 114, 993–1006.CrossRefGoogle Scholar
Olds-Clarke, P. & Peitz, B. (1985). Fertility of sperm from t/+ mice: evidence that +-bearing sperm are dysfunctional. Genetical Research 47, 49–52.CrossRefGoogle Scholar
Röhme, D., Fox, H., Herrmann, B., Frischauf, A.-M., Edstrom, J.-E., Mains, P., Silver, L. M. & Lehrach, H. (1984). Molecular clones of the mouse t complex derived from microdissected metaphase chromosomes. Cell 36, 783–788.CrossRefGoogle Scholar
Sarvetnick, N., Fox, H., Mann, E., Mains, P., Elliott, R. & Silver, L. M. (1986). Nonhomologous pairing in mice heterozygous for a t haplotype can produce recombinant chromosomes with duplications and deletions. Genetics 113, 723–734.CrossRefGoogle Scholar
Silver, L. M. (1985). Mouse t haplotypes. Annual Review of Genetics 19, 179–208.CrossRefGoogle ScholarPubMed
Silver, L. M., Artzt, K. & Bennett, D. (1979). A major testicular cell protein specified by a mouse T/t complex gene. Cell 17, 275–284.CrossRefGoogle Scholar
Silver, L. M., Lukralle, D. & Garrels, J. I. (1983 a). T0rl is a novel, variant form of mouse chromosomal 17 with a deletion in a partial t haplotype. Nature 301, 422–424.CrossRefGoogle Scholar
Silver, L. M., Uman, J., Danska, J. & Garrels, J. I. (1983 b). A diversified set of testicular cell proteins specified by genes within the mouse t complex. Cell 35, 35–45.CrossRefGoogle ScholarPubMed
Silver, L. M., Hammer, M., Fox, H., Garrels, J., Bucan, M., Herrmann, B., Freischauf, A.-M., Lehrach, H., Winking, H., Figueroa, F. & Klein, J. (1987). Molecular evidence for the rapid propagation of mouse t haplotypes from a single, recent, ancestral chromosome. Molecular Biology and Evolution. (In the Press.)Google Scholar
Styrna, J. & Klein, J. (1981). Evidence for two regions in the mouse t complex controlling transmission ratios. Genetical Research 38, 315–325.CrossRefGoogle Scholar
Willison, K. R., Dudley, K. & Potter, J. (1986). Molecular cloning and sequence analysis of a haploid expressed gene encoding r complex polypeptide 1. Cell 44, 727–738.CrossRefGoogle Scholar
Winking, H. & Silver, L. M. (1984). A recombinant mouse t haplotype that expresses a dominant lethal maternal effect. Genetics 108, 1013–1020.CrossRefGoogle ScholarPubMed