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Surgery alone versus post-operative radiotherapy for sinonasal malignant melanoma: a meta-analysis

Published online by Cambridge University Press:  24 January 2019

R Hu  and
B-B Yang
R Hu
Affiliation:
Department of Otolaryngology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China
B-B Yang*
Affiliation:
Department of Otolaryngology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China
*
Author for correspondence: Dr Bei-Bei Yang, Department of Otolaryngology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Jiefang Road 88, Hangzhou 310000, Zhejiang, China E-mail: 2187006@zju.edu.cn
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Abstract

Objective

Sinonasal malignant melanoma is a relatively rare malignancy with poor prognosis, and effective treatments remain elusive. This analysis aimed to explore whether post-operative radiotherapy conferred any survival advantages in patients with this disease when compared with surgery alone.

Methods

Published studies were identified by searching four electronic databases. The endpoints evaluated were: rates of overall survival, disease-free survival and local control.

Results

Twenty-eight studies including 1392 patients were identified. The results indicated that post-operative radiotherapy led to a significantly better three-year overall survival rate (p = 0.02), and suggested a borderline significant benefit for five-year overall survival (p = 0.05), when compared with surgery alone. However, no statistical advantage was found for disease-free survival, local control or one-year overall survival.

Conclusion

This meta-analysis indicated that adjuvant radiotherapy prolonged survival, but showed no benefit for disease-free survival or local control.

Keywords

MelanomaNasal CavityParanasal SinusesSurgical OncologyAdjuvant Radiotherapy

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 12 , December 2018 , pp. 1051 - 1060
Copyright
Copyright © JLO (1984) Limited, 2019 

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Footnotes

Dr B-B Yang takes responsibility for the integrity of the content of the paper

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