Monitoring and Advanced Control of Crystallization Processes

doi:10.1017/9781139026949.011

Chapter 11 - Monitoring and Advanced Control of Crystallization Processes

Published online by Cambridge University Press: 14 June 2019

Mitsuko Fujiwara and

Edited by

Deniz Erdemir and

Allan S. Myerson: Affiliation:
Massachusetts Institute of Technology
Deniz Erdemir: Affiliation:
Bristol-Myers Squibb, USA
Alfred Y. Lee: Affiliation:
Merck & Co., Inc

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Summary

Crystallization is one of the main separation and purification processes in the pharmaceutical, biotechnology, food, microelectronics, fine and bulk chemicals industries. The production of more than 70 percent of all solid products involves at least one crystallization as a key processing step, which can have a significant effect on the overall performance of the entire production process and the properties of the final product. The control of crystallization processes is challenging because of the highly nonlinear dynamics, large variations in length and time scales at which the various simultaneous mechanisms occur, variations in crystallization rates over time owing to variations in the impurity profiles of chemical feedstocks, unexpected polymorphic transformations, and nonideal mixing conditions.

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Type: Chapter
Information: Handbook of Industrial Crystallization , pp. 313 - 345

DOI: https://doi.org/10.1017/9781139026949.011 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2019

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