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Return-on-investment of a mental health intervention for war-affected youth in Sierra Leone

Published online by Cambridge University Press:  16 October 2025

Diana Bowser*
Affiliation:
William F. Connell School of Nursing, Boston College , 140 Commonwealth Ave., Chestnut Hill, MA, USA
Brielle Ruscitti
Affiliation:
William F. Connell School of Nursing, Boston College , 140 Commonwealth Ave., Chestnut Hill, MA, USA
Kathryn Noon
Affiliation:
School of Social Work, Boston College , 140 Commonwealth Ave., Chestnut Hill, MA, USA
Matias Placencio-Castro
Affiliation:
School of Social Work, Boston College , 140 Commonwealth Ave., Chestnut Hill, MA, USA
Jordan Freeman
Affiliation:
Bloomberg School of Public Health, Johns Hopkins University , 615 N Wolfe Street, Baltimore, MD, USA
Theresa S. Betancourt
Affiliation:
School of Social Work, Boston College , 140 Commonwealth Ave., Chestnut Hill, MA, USA
*
Corresponding author: Diana Bowser; Emails: diana.bowser@bc.edu
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Abstract

Mental health interventions, such as Youth Readiness Intervention (YRI), offer an opportunity for improving the mental health of war-affected youth in fragile and conflict-affected regions. The YRI has demonstrated effectiveness in improving mental health outcomes, yet prior analyses have not examined the economic impact of the YRI integrated within with an entrepreneurship (ENTR) program. A costing analysis was conducted using standard activity-based costing methodology to estimate implementation costs. Next, economic benefits (productivity, healthcare offsets and local returns) were estimated, using participant-reported and secondary data. Total benefits were compared with total costs to calculate the return on investment (ROI), taking into consideration varying unemployment rates as a result of the intervention. Results show that the YRI + ENTR implementation cost is $117,289.00 ($305.44 per participant) and the ENTR-alone implementation is $67,279.10 ($177.05 per participant). The ROI for the YRI + ENTR varies from $1.01 to $1.95. The ROI for the ENTR alone varies from $2.53 to $6.92. In one of the ROI pathways – that is, healthcare savings – we find that the YRI + ENTR results in an 8.5-fold larger healthcare saving compared to the ENTR alone. This is one of the first studies to examine the broader economic returns of the YRI and ENTR program and are important to consider in future implementation due to the broad nature of economic benefits.

Information

Type
Research Article
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - ND
This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use and/or adaptation of the article.
Copyright
© The Author(s), 2025. Published by Cambridge University Press
Figure 0

Figure 1. Return on investment analysis theory of change framework.

Figure 1

Table 1. Costs of the YRI and ENTR implementation (2024 USD)

Figure 2

Table 2. Productivity and local multiplier

Figure 3

Table 3. Healthcare utilization and costs estimates, monthly and 12 months (2024 USD)

Figure 4

Table 4. Annual productivity and monthly local multiplier and healthcare offsets

Figure 5

Table 5. Estimated ROI of YRI and ENTR implementation (2024 USD)

Figure 6

Table 6. Estimated ROI of YRI and ENTR Implementation with subsidized implementation of the YRI program (2024 USD)

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Author comment: Return-on-investment of a mental health intervention for war-affected youth in Sierra Leone — R0/PR1

Comments

Dear Global Mental Health Editors,

Please find the attached manuscript entitled Return-on-Investment of a Mental Health Intervention for

War-affected Youth in Sierra Leone, which is under consideration for publication in Global Mental

Health.

This analysis used a comprehensive Return-on-Investment (ROI) analysis framework to quantify the

economic benefits of the Youth Readiness Intervention (YRI) implemented alongside an

entrepreneurship (ENTR) program for war-affected youth in Sierra Leone. The benefits included

productivity (employment), healthcare savings and economic returns to the local community. We first

conducted a costing analysis using standard Activity-Based Costing methodology to determine the

implementation costs associated with the YRI and ENTR programs. The total benefits were

approximated using national secondary and participant level data to estimate healthcare costs,

employment and returns to the local community. The ROI then captured the return per dollar invested

based on the sum of total benefits divided by the total costs. We additionally conduct sensitivity

analyses to estimate the ROI under conditions where implementation costs could be subsidized by

government funding.

The results show that the YRI+ENTR has a higher implementation cost compared to implementing the

ENTR alone. Both programs (compared to the control) have a positive ROI: $2.76 for the YRI+ENTR and

$3.39 for the ENTR alone. We find that the YRI+ENTR results in an 8.5-fold larger healthcare saving

compared to the ENTR alone. Using sensitivity analysis to simulate a reduction in implementation costs

for the YRI+ENTR through government subsidized programs increases the ROI to $3.60. These findings

are important for mental health researchers and policy makers for future implementation of the YRI or

similar programs as we demonstrate the broad range of economic benefits.

This paper has not been published nor submitted for publication by another journal. We confirm that all

authors made substantial contributions to the concept, design, analysis, or interpretation of data and

the drafting or revising of the manuscript, and that all authors have approved the manuscript for

submission. We declare that no authors have any competing interests.

Review: Return-on-investment of a mental health intervention for war-affected youth in Sierra Leone — R0/PR2

Conflict of interest statement

I know the authors, but had no prior knowledge of this work and my knowing them has in no way influenced my review. No other competing interests.

Comments

The study provides a useful input. As the authors note, estimating the value of mental health interventions in such contexts is difficult and traditional cost effectiveness analysis is limited. Providing an analysis of the ROI seeks to address these limitations. The paper could, however, be improved in a few ways related mainly to making decisions clearer and better justified.

The paper would benefit from more explanation of why traditional CEA is not appropriate in this case. The reasons are broadly given, but some further explanation and links to the literature on this topic would be helpful

The ABC is explained, but not the selection of cost categories. Efforts have been made to develop costing guidelines and reporting guidelines. No reference was made to either. I do not have a problem with them not being used, although it does limit comparability, but reasons for their exclusion in favour of these specific categories and this reporting format should be given.

It is not clear what perspective the costing is taking, this should be clarified. The costs to participants of being involved are included, suggesting a fairly broad perspective. But then only the stipend for the facilitators is included, is this because the stipend is considered an appropriate full compensation, or because the volunteer aspect of the contribution is not included from this perspective? If the latter, this would suggest a narrow view, in contracts to that implied by the inclusion of the participant costs. Similarly, in sensitivity analysis, a subsidy is suggested to decrease costs, when it only shifts who carries them, unless you have a (very in this case) narrow perspective.

There appear to be no management or indirect costs. This is a curious omission and needs to be justified. Similarly, only fuel costs are included, and no wear and tear on the cars. The case for inclusion or exclusion would have been helped by the use of standard guidelines.

The approach to estimating productivity returns via employment variations and GDP needs further explanation. I think, by the end, I understood the approach, but it could certainly be clearer. It also requires some justification, including for its application to this particular population.

The multiplier should also be justified better. Is the assumption that the increased income/productivity for the participants is entirely new as opposed to redirected? The interventions may make them more competitive in the labour market, leading to them taking jobs from others, rather than leading to new jobs. They may then be more productive in those positions than the people they took them from, but this would mean only a portion of the income increase is new.

The comparison to ROI results from other mental health interventions should be more detailed. There are other studies which have shown higher returns and some lower, the full range should be commented on.

The writing in general is fine, but could be improved. The introduction needs the most attention as there are a few grammatical errors, but more importantly, it does not flow well. Also, the term ‘treatment gap’ is inappropriately used.

Review: Return-on-investment of a mental health intervention for war-affected youth in Sierra Leone — R0/PR3

Conflict of interest statement

Reviewer declares none.

Comments

Thank you for your paper.

Some comments/feedback:

1. Please state the perspective of the analysis (e.g. “societal” “health system” etc.). More generally, I would suggest more generally that you complete a “CHEERS” checklist for reporting of economic evidence relating to programe evaluation/appraisal (or the US equivalent). https://www.equator-network.org/reporting-guidelines/cheers/

2. You’ve converted to USD using a simple exchange rate approach (page 4). You may also want to consider (alongside your existing values) presenting purchasing power parity (PPP) adjusted $ values to allow for differences in input price differentials (i.e. what would the same programme package cost if provided in the US).

3. The method for selecting the the survey sample isn’t included in the paper (random, convenience sample etc.). Also, how did survey respondents compare to those who were originally randomized in your hybrid trial (e.g. against trial baseline characteristics)? Were response rates better by trial arm? There is also a risk that people who participated in the trial who didn’t respond had worse/better employment and other outcomes to those who could be observed. Bias arising from sample section and missing data isn’t discussed in the paper (particularly your section on limitations).

4. Table 3 (page 9): its unclear what the N values are referring to in this table.

5. In table 4, your refer to “annual health care off-sets”. But this is misleading, as they are just extrapolations from 3 month data from the survey to cover a 12 month period. They cannot be reasonably be assumed to be annual offsets over future periods has participants get older. If you intended these to refer to short-term 12 month offsets then please make this clearer in the table. Similarly for the impacts related to the multiplier effect.

5. From page 5 “We utilized a standard GDP growth rate of 2.5% and a discount rate of 5% for the calculation”. Why is this standard? It isn’t clear where the 2.5% value comes from (is from the World Bank citation?)? Either way, this must be based on a projection of future growth in GDP which will carry a degree of uncertainty over such an extended period. I feel this should either be brought out in the limitations section or perhaps handled in the sensitivity analysis by adopting varying growth assumptions.

6. Your survey based estimates of health care costs (table 3) and employment/mortality rates used to adjusted productivity benefits do not report measures of uncertainty around mean values within trial groups or the differences (I would recommend using 95% confidence intervals). It is important that these uncertainties are communicated given that your trial estimates are sampled from a population. Ideally these would be incorporated into the sensitivity analysis but at the very least should be discussed as a risk or limitation to the what can be inferred from the ROI analysis using the “base case” numbers reported in the tables.

7. I am not familiar with estimating multiplier effects for use within economic evaluation/appraisal. While the logic of their inclusions seems justified, they could potentially magnify estimated programme benefits. I would therefore recommend that you provide a more detailed justification for the methods employed to estimate these impacts backed-up with some appropriate references to the relevant methods literature.

8. I think your reported ROI values could risk overstating the case for the programme options considered in your analysis. The estimate of productivity benefits will to some extent assume that the effect of YRI on mental health and employment participation levels will be sustained overtime - this seems optimistic to me (unless there is longer-term follow-up evidence to back this up). Also, employment rates will be dependent on external factors (e.g. wider economic climate, presence/absence of conflict). I would suggest communicating these risks and uncertainties in your discussion section (and ideally it would be good to try and accommodate formally in sensitivity analysis if feasible).

I hope these comments are helpful.

Review: Return-on-investment of a mental health intervention for war-affected youth in Sierra Leone — R0/PR4

Conflict of interest statement

Reviewer declares none.

Comments

Thank you for the opportunity to review your manuscript. It presents a timely and well-structured analysis of the YRI combined with an ENTR, focusing on its economic impact in a post-conflict setting. Integrating cost analysis and ROI modelling provides valuable insights for mental health policy in LMICs. I commend your team for addressing a critical knowledge gap and for employing a clear, evidence-based economic evaluation framework. After a detailed review, I find the manuscript to be methodologically sound and a strong candidate for publication, pending minor revisions to enhance clarity, consistency, and completeness. Below, I outline specific comments and suggestions for your consideration:

1) While you acknowledge the limited reach of the follow-up telephone survey (approximately half of the original participants), I encourage you to elaborate on how this may affect the generalisability of your ROI estimates. Discuss whether attrition could introduce bias in income or healthcare utilisation metrics.

2) The finding that the YRI+ENTR group had higher inpatient hospital costs but lower overall healthcare costs deserves deeper exploration. This may be due to increased health literacy or improved financial access. A brief paragraph clarifying this nuance would enhance the discussion.

3) If possible, consider adding a note on whether subgroup effects (e.g., by gender or age) were explored or feasible given the sample size. Alternatively, mention this as a limitation.

4) Your sensitivity analysis showing improved ROI under government-subsidised implementation is compelling. I recommend briefly commenting on any systemic or logistical barriers that may exist for scaling up in real-world settings in Sierra Leone.

5) Make minor corrections throughout. These include, but are not limited to: minor typographic issues (e.g., “offers opportunity” → “offer an opportunity”; “there is is” → “there is”); standardising the format of monetary units (“$305.44” vs “305.44usd”); clarifying abbreviations such as “NPV” and “DERS” at their first mention in the text and in tables; improve figure/table formatting—especially Figure 1—to enhance the Theory of Change framework visually (currently, it lacks the directional clarity expected of such logic models); and check the references section, ensuring that all citations are unique (e.g., McBain et al. appears twice as #24 and #25).

In short, I believe this study makes an important contribution to the literature on economic evaluation of mental health programs in post-conflict and low-resource settings. The work is innovative, relevant, and appropriately grounded in both policy and scientific evidence. I recommend acceptance with minor revisions. Thank you again for your important contribution to the field.

Recommendation: Return-on-investment of a mental health intervention for war-affected youth in Sierra Leone — R0/PR5

Comments

No accompanying comment.

Decision: Return-on-investment of a mental health intervention for war-affected youth in Sierra Leone — R0/PR6

Comments

No accompanying comment.

Author comment: Return-on-investment of a mental health intervention for war-affected youth in Sierra Leone — R1/PR7

Comments

June 18th, 2025

From: Diana Bowser

140 Commonwealth Ave, Chestnut Hill, MA

To: Cambridge Prisms: Global Mental Health

Subject: Cambridge Prisms: Global Mental Health - Decision on GMH-2025-0057

Dear Global Mental Health Reviewers,

This document presents the research team’s responses to the comments received from Global Mental Health reviewers. The latest revised manuscripts are attached, and responses to revisions are detailed below (in bold). We have provided a clean copy and a marked copy of the manuscript, with tracked changes turned on. We hope this clarifies all the comments and feedback and remain at your disposal to resolve any remaining doubts. We want to thank the reviewers for their excellent comments and believe that the manuscript is considerably improved with all the revisions incorporated.

Editorial Comments:

- Please include an Impact Statement below the abstract (max. 300 words). This must not be a repetition of the abstract but a plain worded summary of the wider impact of the article.

We have moved the Impact Statement below the abstract, and edited accordingly to ensure that the wider impact of the article is captured.

- Submission of graphical abstracts is encouraged for all articles to help promote their impact online. A Graphical Abstract is a single image that summarises the main findings of a paper, allowing readers to quickly gain an overview and understanding of your work. Ideally, the graphical abstract should be created independently of the figures already in the paper, but it could include a (simplified version of) an existing figure or a combination thereof. If you do not wish to include a graphical abstract please let me know.

We have included a graphical abstract for this manuscript and have uploaded it with the revisions.

- Please ensure references are correctly formatted. In text citations should follow the author and year style. When an article cited has three or more authors the style ‘Smith et al. 2013’ should be used on all occasions. At the end of the article, references should first be listed alphabetically, with a full title of each article, and the first and last pages. Journal titles should be given in full.

We have reviewed all references to ensure they are formatted correctly.

- Statements of the following are required at the end of all articles: ‘Author Contribution Statement’, ‘Financial Support’, ‘Conflict of Interest Statement’, ‘Ethics statement’ (if appropriate), ‘Data Availability Statement’. Please see the author guidelines for further information.

We have reviewed the requirements and confirm they are listed at the end of the article.

- Please submit figures as separate files in jpg/tiff format and please ensure all main text files are submitted in an editable electronic format (word/tex).

The figure has been uploaded as a jpg file.

Reviewer 1:

Comments to the Author

The study provides a useful input. As the authors note, estimating the value of mental health interventions in such contexts is difficult and traditional cost effectiveness analysis is limited. Providing an analysis of the ROI seeks to address these limitations. The paper could, however, be improved in a few ways related mainly to making decisions clearer and better justified.

The paper would benefit from more explanation of why traditional CEA is not appropriate in this case. The reasons are broadly given, but some further explanation and links to the literature on this topic would be helpful

Thank you for this comment, we have expanded on the limitations of CEA in the introduction and discussion and rationale for the ROI methodology in the discussion.

The ABC is explained, but not the selection of cost categories. Efforts have been made to develop costing guidelines and reporting guidelines. No reference was made to either. I do not have a problem with them not being used, although it does limit comparability, but reasons for their exclusion in favor of these specific categories and this reporting format should be given.

Thank you for this comment. In order to respond to this comment and better explain the ABC methodology and how our cost categories overlap with ABC methodology (including references), we have expanded upon and clarified the explanation of the cost categories in the methods. As explained, while we followed ABC methodology and collected three standard categories of costs (personnel, recurrent and capital), since there were no salaried personnel and no capital purchases, all costs fell into the recurrent cost category. The costing analysis was conducted in coordination with in-country staff and other members of the research team who participated in implementation.

It is not clear what perspective the costing is taking, this should be clarified. The costs to participants of being involved are included, suggesting a fairly broad perspective. But then only the stipend for the facilitators is included, is this because the stipend is considered an appropriate full compensation, or because the volunteer aspect of the contribution is not included from this perspective? If the latter, this would suggest a narrow view, in contracts to that implied by the inclusion of the participant costs. Similarly, in sensitivity analysis, a subsidy is suggested to decrease costs, when it only shifts who carries them, unless you have a (very in this case) narrow perspective.

Thank you for this comment, we utilized a societal perspective that included both staff and participant time in the cost analysis and health care offsets and productivity as part of the benefit analysis. We have clarified in the methods that the stipend for facilitators was considered appropriate full compensation. In regard to the sensitivity analysis, we agree that the costs would shift, however, the sensitivity analysis captures what would happen if participant stipends were reduced to match the stipend that was given for the ENTR program, reducing the overall cost.

There appear to be no management or indirect costs. This is a curious omission and needs to be justified. Similarly, only fuel costs are included, and no wear and tear on the cars. The case for inclusion or exclusion would have been helped by the use of standard guidelines.

These are key points. We have added an additional explanation of the rental costs-to capture the space for some of the intervention activities and as a proxy for indirect cost of implementing the YRI and ENTR. In addition, we have clarified in the methods that only fuel costs were included as the vehicles were rented and therefore no depreciation of the vehicles was needed.

The approach to estimating productivity returns via employment variations and GDP needs further explanation. I think, by the end, I understood the approach, but it could certainly be clearer. It also requires some justification, including for its application to this particular population.

Thank you for this comment. We have reviewed the paragraph to ensure the explanation of the productivity returns accounting for employment and mortality is clearer. Given the uncertainty in the self-reported income in the telephone survey we used GDP per capita as a proxy for the participant’s income. We have noted in the limitation section that the use of GDP per capita is subject to limitations.

The multiplier should also be justified better. Is the assumption that the increased income/productivity for the participants is entirely new as opposed to redirected? The interventions may make them more competitive in the labour market, leading to them taking jobs from others, rather than leading to new jobs. They may then be more productive in those positions than the people they took them from, but this would mean only a portion of the income increase is new.

We have clarified that the local multiplier approach captures where individuals are spending their income. This does not capture their income, but rather their spending and the returns to the community. We have added additional references for the local multiplier and clarified the approach.

The comparison to ROI results from other mental health interventions should be more detailed. There are other studies which have shown higher returns and some lower, the full range should be commented on.

Thank you for this comment, we have expanded upon the comparison to other ROI results in the discussion. A scoping review has noted that economic evaluations using a social return on investment framework result in even larger returns, which is an area for future study.

The writing in general is fine, but could be improved. The introduction needs the most attention as there are a few grammatical errors, but more importantly, it does not flow well. Also, the term ‘treatment gap’ is inappropriately used.

We have reviewed the manuscript to ensure that the introduction has improved flow and reframed the information around the treatment gap.

Reviewer 2:

Comments to the Author

Thank you for your paper.

Some comments/feedback:

1. Please state the perspective of the analysis (e.g. “societal” “health system” etc.). More generally, I would suggest more generally that you complete a “CHEERS” checklist for reporting of economic evidence relating to programe evaluation/appraisal (or the US equivalent). https://www.equator-network.org/reporting-guidelines/cheers/

Thank you for this comment, we have clarified that the costing analysis used a societal perspective. We have also completed a CHEERS checklist for this analysis and have provided this as an annex material.

2. You’ve converted to USD using a simple exchange rate approach (page 4). You may also want to consider (alongside your existing values) presenting purchasing power parity (PPP) adjusted $ values to allow for differences in input price differentials (i.e. what would the same programme package cost if provided in the US).

Thank you for this comment, we have created an additional annex table of the cost analysis, which in terms of purchasing power parity. This is shown in Annex Table 5. We agree that the use of the PPP allows for a broader understanding of the cost of the intervention.

3. The method for selecting the survey sample isn’t included in the paper (random, convenience sample etc.). Also, how did survey respondents compare to those who were originally randomized in your hybrid trial (e.g. against trial baseline characteristics)? Were response rates better by trial arm? There is also a risk that people who participated in the trial who didn’t respond had worse/better employment and other outcomes to those who could be observed. Bias arising from sample section and missing data isn’t discussed in the paper (particularly your section on limitations).

We have added a section to the methods (Data Collection) that explains the methodology for the telephone survey sample and data collection. We have also provided a full sampling methodology for both YRI participation and follow-up surveys, and provided this as a Methods Annex.

4. Table 3 (page 9): its unclear what the N values are referring to in this table.

We have updated Table 3 to explain the N values, which refer to the number of respondents in each study arm that reported using each type of healthcare service. We have updated the note to reflect this explanation.

5. In table 4, your refer to “annual health care off-sets”. But this is misleading, as they are just extrapolations from 3 month data from the survey to cover a 12 month period. They cannot be reasonably be assumed to be annual offsets over future periods has participants get older. If you intended these to refer to short-term 12 month offsets then please make this clearer in the table. Similarly for the impacts related to the multiplier effect.

Thank you for this comment. Yes, as you suggest, we have extrapolated the reported healthcare utilization from the survey to the 12 month period. We agree that this 12 month utilization cannot be assumed over a longer period of time. We have only utilized the 12 month estimate throughout the analysis. We have renamed the annual healthcare offsets to make it clearer in the Table 4 that this is 12-month utilization.

5. From page 5 “We utilized a standard GDP growth rate of 2.5% and a discount rate of 5% for the calculation”. Why is this standard? It isn’t clear where the 2.5% value comes from (is from the World Bank citation?)? Either way, this must be based on a projection of future growth in GDP which will carry a degree of uncertainty over such an extended period. I feel this should either be brought out in the limitations section or perhaps handled in the sensitivity analysis by adopting varying growth assumptions.

Thank you for this comment, we have removed the word standard, and added references to support this choice. We utilized this rate to capture an average growth rate to account for unobserved future variations. We have created an additional annex table to show the ROI using a higher growth rate (GDP growth rate of 5% and 5% discount) in Annex Table 6. As suggested, we have noted in the limitations the uncertainty of the future GDP growth, especially for Sierra Leone.

6. Your survey-based estimates of health care costs (table 3) and employment/mortality rates used to adjusted productivity benefits do not report measures of uncertainty around mean values within trial groups or the differences (I would recommend using 95% confidence intervals). It is important that these uncertainties are communicated given that your trial estimates are sampled from a population. Ideally these would be incorporated into the sensitivity analysis but at the very least should be discussed as a risk or limitation to the what can be inferred from the ROI analysis using the “base case” numbers reported in the tables.

We agree that reporting uncertainty measures are important. As such, we have added standard deviations where possible on survey-based estimates for income utilized in the local multiplier and unemployment utilized in the productivity estimation—adding a revised analysis that incorporated both low and high unemployment---which has changed the overall ROI results.

We are unable to report standard deviations on healthcare costs as these data were extracted from secondary literature that did not report standard deviations. We have noted this as a limitation and that our estimates would be impacted if costs were to increase or decrease.

7. I am not familiar with estimating multiplier effects for use within economic evaluation/appraisal. While the logic of their inclusions seems justified, they could potentially magnify estimated programme benefits. I would therefore recommend that you provide a more detailed justification for the methods employed to estimate these impacts backed-up with some appropriate references to the relevant methods literature.

Thank you for this comment we have clarified the methods related to the local multiplier effect and added additional references. We want to note that the local multiplier does not capture the participant income, but rather their spending and the returns to the community.

8. I think your reported ROI values could risk overstating the case for the programme options considered in your analysis. The estimate of productivity benefits will to some extent assume that the effect of YRI on mental health and employment participation levels will be sustained overtime - this seems optimistic to me (unless there is longer-term follow-up evidence to back this up). Also, employment rates will be dependent on external factors (e.g. wider economic climate, presence/absence of conflict). I would suggest communicating these risks and uncertainties in your discussion section (and ideally it would be good to try and accommodate formally in sensitivity analysis if feasible).

We agree that demonstrating sustainment of program benefits is key. Follow-up analyses on program outcomes, not yet published, show that YRI+ENTR youth maintain improvements in depression and combined depression and anxiety symptoms.

We have also expanded upon the discussion related to employment levels of youth as a limitation. We utilize the average unemployment rate throughout the productivity analysis to capture that across the working life, an average percent of individuals in each study arm will be unemployed—based on the unemployment rate estimated within the study (1.80% YRI+ENTR, 0.70% ENTR, and 2.68% Control). While these rates may change over time (higher or lower), we have applied these rates to the entire life time earning to account for unemployment over time. We have noted that this is subject to external factors which could be explored further with additional follow-up data.

I hope these comments are helpful.

Reviewer 3:

Reviewer: 3

Comments to the Author

Thank you for the opportunity to review your manuscript. It presents a timely and well-structured analysis of the YRI combined with an ENTR, focusing on its economic impact in a post-conflict setting. Integrating cost analysis and ROI modelling provides valuable insights for mental health policy in LMICs. I commend your team for addressing a critical knowledge gap and for employing a clear, evidence-based economic evaluation framework. After a detailed review, I find the manuscript to be methodologically sound and a strong candidate for publication, pending minor revisions to enhance clarity, consistency, and completeness. Below, I outline specific comments and suggestions for your consideration:

1) While you acknowledge the limited reach of the follow-up telephone survey (approximately half of the original participants), I encourage you to elaborate on how this may affect the generalisability of your ROI estimates. Discuss whether attrition could introduce bias in income or healthcare utilisation metrics.

We have updated the methods section with an additional data collection section to clarify the sampling strategy and data collection methods for the follow-up telephone survey. We have provided a full explanation of the sampling and recruitment methodology in the Methods Annex. We have noted in the limitations that this may still impact the estimates for healthcare utilization.

2) The finding that the YRI+ENTR group had higher inpatient hospital costs but lower overall healthcare costs deserves deeper exploration. This may be due to increased health literacy or improved financial access. A brief paragraph clarifying this nuance would enhance the discussion.

This is a key insight, we have expanded upon this in the discussion to highlight that YRI program benefits may include better reasoning, symptom knowledge and problem solving, which may lead these individuals to seek necessary care.

3) If possible, consider adding a note on whether subgroup effects (e.g., by gender or age) were explored or feasible given the sample size. Alternatively, mention this as a limitation.

Thank you for noting this – we have added this as a limitation as subgroup effects were not examined due to the sample size. The study was powered to estimate significant differences in program outcomes, the study was not powered by gender nor for the cost analysis.

4) Your sensitivity analysis showing improved ROI under government-subsidised implementation is compelling. I recommend briefly commenting on any systemic or logistical barriers that may exist for scaling up in real-world settings in Sierra Leone.

Thank you for highlighting this as we think the government-subsidized implementation may lead to broader uptake, but agree there may be additional barriers faced. We have expanded upon this in our discussion.

5) Make minor corrections throughout. These include, but are not limited to: minor typographic issues (e.g., “offers opportunity” → “offer an opportunity”; “there is is” → “there is”); standardising the format of monetary units (“$305.44” vs “305.44usd”); clarifying abbreviations such as “NPV” and “DERS” at their first mention in the text and in tables; improve figure/table formatting—especially Figure 1—to enhance the Theory of Change framework visually (currently, it lacks the directional clarity expected of such logic models); and check the references section, ensuring that all citations are unique (e.g., McBain et al. appears twice as #24 and #25).

We have adjusted these typographic issues throughout. We have also updated Figure 1 to improve directional clarity.

In short, I believe this study makes an important contribution to the literature on economic evaluation of mental health programs in post-conflict and low-resource settings. The work is innovative, relevant, and appropriately grounded in both policy and scientific evidence. I recommend acceptance with minor revisions. Thank you again for your important contribution to the field.

Review: Return-on-investment of a mental health intervention for war-affected youth in Sierra Leone — R1/PR8

Conflict of interest statement

Reviewer declares none.

Comments

Thank you for the opportunity to review the revised manuscript. I commend the authors for their thorough and thoughtful response to the previous round of feedback. The revised manuscript is significantly improved in both clarity and methodological transparency. The authors have successfully addressed nearly all major concerns raised by reviewers.

Minor copyediting issues remain, particularly in the abstract and throughout a few sections where grammar or stylistic consistency could be improved, but these are easily addressed with a final proofread. As an example, the revised abstract “offers an opportunity” should be “offer an opportunity”, suggesting one more copyediting pass would be helpful.

In sum, the manuscript is now methodologically sound, well-contextualized, and policy-relevant. I recommend acceptance pending minor editorial corrections.

Review: Return-on-investment of a mental health intervention for war-affected youth in Sierra Leone — R1/PR9

Conflict of interest statement

Reviewer declares none.

Comments

Overall I appreciate the authors' efforts to engage with all of the comments. I have some remaining concerns about the multiplier and the use of GDP per capita as a proxy for income, but given the supporting references provided I don’t think it necessary to press this issue.

I understand the addition of a proxy for indirect costs but am still unclear about the management costs. Was no one employed to manage this program? Who managed the funding? Maybe I have missed something.

Recommendation: Return-on-investment of a mental health intervention for war-affected youth in Sierra Leone — R1/PR10

Comments

Thank you for your careful revision of the manuscript. I’m happy to share a positive outcome. Kindly review the few minor comments noted below.

Decision: Return-on-investment of a mental health intervention for war-affected youth in Sierra Leone — R1/PR11

Comments

No accompanying comment.

Author comment: Return-on-investment of a mental health intervention for war-affected youth in Sierra Leone — R2/PR12

Comments

Dear Global Mental Health Editors,

Please find the attached manuscript entitled Return-on-Investment of a Mental Health Intervention for

War-affected Youth in Sierra Leone, which is under consideration for publication in Global Mental

Health.

This analysis used a comprehensive Return-on-Investment (ROI) analysis framework to quantify the

economic benefits of the Youth Readiness Intervention (YRI) implemented alongside an

entrepreneurship (ENTR) program for war-affected youth in Sierra Leone. The benefits included

productivity (employment), healthcare savings and economic returns to the local community. We first

conducted a costing analysis using standard Activity-Based Costing methodology to determine the

implementation costs associated with the YRI and ENTR programs. The total benefits were

approximated using national secondary and participant level data to estimate healthcare costs,

employment and returns to the local community. The ROI then captured the return per dollar invested

based on the sum of total benefits divided by the total costs. We additionally conduct sensitivity

analyses to estimate the ROI under conditions where implementation costs could be subsidized by

government funding.

The results show that the YRI+ENTR has a higher implementation cost compared to implementing the

ENTR alone. Both programs (compared to the control) have a positive ROI: $1.01 for the YRI+ENTR and

$2.53 for the ENTR alone. We find that the YRI+ENTR results in an 8.5-fold larger healthcare saving

compared to the ENTR alone. Using sensitivity analysis to simulate a reduction in implementation costs

for the YRI+ENTR through government subsidized programs increases the ROI to $1.32. These findings

are important for mental health researchers and policy makers for future implementation of the YRI or

similar programs as we demonstrate the broad range of economic benefits.

This paper has not been published nor submitted for publication by another journal. We confirm that all

authors made substantial contributions to the concept, design, analysis, or interpretation of data and

the drafting or revising of the manuscript, and that all authors have approved the manuscript for

submission. We declare that no authors have any competing interests.

Sincerely,

Diana Bowser

Professor and Associate Dean for Research and Integrated Science

REACH Lab (Research on Economic Analyses and Costing for Health systems)

William F. Connell School of Nursing

Boston College

Email: diana.bowser@bc.edu

Review: Return-on-investment of a mental health intervention for war-affected youth in Sierra Leone — R2/PR13

Conflict of interest statement

Reviewer declares none.

Comments

I would still prefer the inclusion of at least a portion of the time of higher level managers. That said, I appreciate the difficulty of separating this for their research duties and think that the note in the limitations allows readers to better understand the situation.

Recommendation: Return-on-investment of a mental health intervention for war-affected youth in Sierra Leone — R2/PR14

Comments

Thank you for addressing reviewers comments

Decision: Return-on-investment of a mental health intervention for war-affected youth in Sierra Leone — R2/PR15

Comments

No accompanying comment.