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Computerised Tomography in Schizophrenia

Familial Versus Non-Familial Forms of Illness

Published online by Cambridge University Press:  02 January 2018

H. Kaiya ,
M. Uematsu ,
M. Ofuji ,
A. Nishida ,
M. Morikiyo  and
S. Adachi
H. Kaiya*
Affiliation:
Department of Neurology and Psychiatry, Gifu University School of Medicine, 40 Tsukasamachi, 500 Gifu, Japan
M. Uematsu
Affiliation:
Department of Neurology and Psychiatry, Gifu University School of Medicine
M. Ofuji
Affiliation:
Department of Neurology and Psychiatry, Gifu University School of Medicine
A. Nishida
Affiliation:
Department of Neurology and Psychiatry, Gifu University School of Medicine
M. Morikiyo
Affiliation:
Department of Neurology and Psychiatry, Gifu University School of Medicine
S. Adachi
Affiliation:
Department of Psychiatry, Gifu City Hospital
*
∗ Correspondence
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Abstract

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Findings on CT and demographical or clinical data in 80 patients with DSM–III schizophrenia and 45 medical controls were evaluated. Multiple-discriminant analysis showed that the enlargement of the third ventricle and frontal and parietal atrophy could significantly predict the diagnosis of schizophrenia. Widening of Sylvian fissures and parietal atrophy differentiated familial schizophrenics of both horizontal transmission (who had affected siblings) and vertical transmission (who had affected parents or/and offspring) from non-familial patients. Parietal atrophy and a history of birth complications differentiated horizontal from vertical transmission. The CT findings together with some clinical characteristics could differentiate the three subgroups classified by the hereditary form; thus each of these subgroup may belong to a different disease entity, of a different pathophysiology.

Information

Type
Papers
Information
The British Journal of Psychiatry , Volume 155 , Issue 4 , October 1989 , pp. 444 - 450
Copyright
Copyright © Royal College of Psychiatrists 1989 

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