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NF-κB: a mediator that promotes or inhibits angiogenesis in human diseases?

Published online by Cambridge University Press:  28 July 2023

Yijing Jiang Open the ORCID record for Yijing Jiang [Opens in a new window] ,
Jie Zhang ,
Conglin Shi ,
Xingjuan Li ,
Yongying Jiang  and
Renfang Mao Open the ORCID record for Renfang Mao [Opens in a new window]
Yijing Jiang
Affiliation:
Department of Pathophysiology, School of Medicine, Nantong University, 19 Qixiu Road, Nantong 226001, Jiangsu, People's Republic of China
Jie Zhang
Affiliation:
Department of Oncology, Affiliated Tumor Hospital of Nantong University, 30Tongyang North Road, Pingchao Town, Nantong 226361, Jiangsu, People's Republic of China
Conglin Shi
Affiliation:
Department of Pathogenic Biology, School of Medicine, Nantong University, 19 Qixiu Road, Nantong 226001, Jiangsu, People's Republic of China
Xingjuan Li
Affiliation:
Department of Pathophysiology, School of Medicine, Nantong University, 19 Qixiu Road, Nantong 226001, Jiangsu, People's Republic of China
Yongying Jiang
Affiliation:
Department of Pathophysiology, School of Medicine, Nantong University, 19 Qixiu Road, Nantong 226001, Jiangsu, People's Republic of China
Renfang Mao*
Affiliation:
Department of Pathophysiology, School of Medicine, Nantong University, 19 Qixiu Road, Nantong 226001, Jiangsu, People's Republic of China
*
Corresponding author: Renfang Mao; Email: maorenfang@ntu.edu.cn
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Abstract

The nuclear factor of κ-light chain of enhancer-activated B cells (NF-κB) signaling pathway, which is conserved in invertebrates, plays a significant role in human diseases such as inflammation-related diseases and carcinogenesis. Angiogenesis refers to the growth of new capillary vessels derived from already existing capillaries and postcapillary venules. Maintaining normal angiogenesis and effective vascular function is a prerequisite for the stability of organ tissue function, and abnormal angiogenesis often leads to a variety of diseases. It has been suggested that NK-κB signalling molecules under pathological conditions play an important role in vascular differentiation, proliferation, apoptosis and tumourigenesis by regulating the transcription of multiple target genes. Many NF-κB inhibitors are being tested in clinical trials for cancer treatment and their effect on angiogenesis is summarised. In this review, we will summarise the role of NF-κB signalling in various neovascular diseases, especially in tumours, and explore whether NF-κB can be used as an attack target or activation medium to inhibit tumour angiogenesis.

Keywords

nuclear factor-κB (NF-κB)pathological angiogenesistherapytumourigenesis

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Type
Review
Information
Expert Reviews in Molecular Medicine , Volume 25 , 2023 , e25
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Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press

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Footnotes

*

These authors made equal contributions to this work.

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