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Mast cells in aural polyps: a preliminary report

Published online by Cambridge University Press:  29 June 2007

S. S. M. Hussain  and
J. M. Hopkinson
S. S. M. Hussain*
Affiliation:
Department of Otolaryngology, The General Infirmary at Leeds, and York District Hospital.
J. M. Hopkinson
Affiliation:
Department of Histopathology, The General Infirmary at Leeds, and York District Hospital.
*
Address for correspondence: Mr S. S. M. Hussain, Department of ENT Surgery, The General Infirmary at Leeds, Great George Street, Leeds LSI 3EX.
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Abstract

Mast cells are a rich source of potent biologically active mediators and are found in connective tissue, associated with blood vessels in many varied inflammatory conditions. Mast cells have been described in nasal polyps and turbinates and in adenoidal tissue in the upper aerodigestive tract. As the middle ear lining is contiguous with the nose and the nasopharynx, the presence of mast cells in aural polyps is interesting.

This preliminary study investigated the presence of mast cells in inflammatory aural polyps using light microscopy. All patients presenting to the department in one year were included. Patients with previous ear disease or surgery and in whom cholesteatoma was suspected were excluded. Except for one patient mast cells were seen in all aural polyps. The implications of these findings is discussed. Further work is needed using electron microscopy.

Keywords

Ear, middlePolypsMast cellsAllergy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 6 , June 1995 , pp. 491 - 494
Copyright
Copyright © JLO (1984) Limited 1995

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References

Borge, P. (1983) Atopy and secretory otitis media. Immunological studies and responses to topical corticosteroid therapy. Journal of Laryngology and Otology 97: 117–129.CrossRefGoogle ScholarPubMed
Browning, G. G., Gatehouse, S., Calder, I. T. (1988) Medical management of active chronic otitis media: a controlled study. Journal of Laryngology and Otology 102: 491–495.CrossRefGoogle ScholarPubMed
Burns, D. K., Meyerhoff, W. L. (1991) Granulomatous disorders and related conditions of the ear and temporal bone, In Otolaryngology. 3rd Edition. Vol. II. (Paparella, M. D., Shumrick, D. A., Gluckman, J. L., Meyerhoff, W. L., eds.), W. B. Saunders and Co., Philadelphia, pp 1529–1559.Google Scholar
Busutill, A., More, I., McSeveney, D. (1976) Ultrastructure of the stroma of nasal polyps. Archives of Otolaryngology 102: 589–595.CrossRefGoogle Scholar
Cauna, N., Hindover, K., Manzethi, G., Swanson, E. (1972) Fine structure of nasal polyps. Annals of Otology, Rhinology and Laryngology 81: 41–58.CrossRefGoogle ScholarPubMed
Drake-Lee, A., Barker, T., Thurley, K. (1984) Nasal polyps (2). Fine structure of mast cells. Journal of Laryngology and Otology 98: 285–292.CrossRefGoogle Scholar
Drake-Lee, A., Price, J. M., Milford, C. M., Bickerton, R. C. (1987) Nasal mast cells: a preliminary report on their ultrastructure. Journal of Laryngology and Otology 101 (suppl 13): 1–17.CrossRefGoogle Scholar
Drake-Lee, A., Price, J. (1992) A review of the morphology of human nasal cells as studied by light and electron microscopy. Rhinology 30: 229–239.Google ScholarPubMed
Ehrlich, P. (1879) Beitrage zur Kenntnis der granulierten Bindegewebszellen und der Eosinophilen Leukozyten. Anatomy und Physiology (Leipzig) 3: 166–169.Google Scholar
Enerback, L. (1981) The gut mucosal mast cells. Monographs of Allergy 17: 222–232.Google Scholar
Enerback, L., Pipkorn, U., Granurus, G. (1986) Intraepithelial mast cells in hay fever. International Archives of Allergy and Applied Immunology 80: 44–51.CrossRefGoogle ScholarPubMed
Hurst, D. S. (1990) Allergy management and refractory otitis media. Otolaryngology-Head and Neck Surgery 102: 664–669.CrossRefGoogle Scholar
Hussain, S. S. M. (1991) Histology of aural polyp as a predictor of middle ear disease activity. Journal of Laryngology and Otology 105: 268–269.CrossRefGoogle ScholarPubMed
Hussain, S. S. M. (1992) Conservative treatment in the management of inflammatory aural polyp. Journal of Laryngology and Otology 106: 313–315.CrossRefGoogle ScholarPubMed
Lederer, F. L. (1941) Clinical significance of aural polpys. Archives of Otolaryngology 33: 1008–1027.CrossRefGoogle Scholar
Loh, L. E. (1987) How benign are aural polyps? Singapore Medical Journal 28: 249–250.Google ScholarPubMed
Milroy, C. M., Slack, R. W. T., Maw, A. R., Bradfield, J. W. B. (1989) Aural polyps as predictors of underlying cholesteatoma. Journal of Clinical Pathology 42: 460–465.CrossRefGoogle ScholarPubMed
Naclero, R., Togias, A., Ptoud, D., Kagey-Sobotka, A., Adkinson, N., Norman, P., Lichenstein, L. (1985) The measurement of inflammatory mediators in nasal secretions. In Immunobiology, Autoimmunity and Transplantation in Otorhinolaryngology (Veldman, J. E., ed.), Kugler Publications, Amsterdam, pp 273–278.Google Scholar
Rhŷs-Williams, S., Robinson, P. J., Brightwell, A. P. (1989) Management of inflammatory aural polpy. Journal of Laryngology and Otology 103: 1040–1042.CrossRefGoogle Scholar
Scadding, G. K., Martin, J. A. M., Alles, R. S., Hawk, L. J., Darby, Y. (1993) Persistent glue ear in children. British Medical Journal 306: 455.CrossRefGoogle ScholarPubMed
Stobel, S., Miller, H., Ferguson, A. (1981) Human intestinal mast cells: evaluation of fixation and staining techniques. Journal of Clinical Pathology 34: 851–858.CrossRefGoogle Scholar
Viegas, M., Gomes, E., Brooks, J., Gatland, D., Davis, R. (1987) Effects of the pollen season in nasal mast cells. British Medical Journal 295: 414.CrossRefGoogle Scholar
Veitch, D., Brockbank, M., Whittet, H. (1988) Aural polyp and cholesteatoma. Clinical Otolaryngology 13: 395–397.CrossRefGoogle ScholarPubMed