Hostname: page-component-6766d58669-6mz5d Total loading time: 0 Render date: 2026-05-21T18:39:50.278Z Has data issue: false hasContentIssue false
  • English
  • Français

Laryngeal Kaposi's sarcoma in patients with AIDS

Published online by Cambridge University Press:  29 June 2007

George Mochloulis ,
Richard M. Irving ,
Henry R. Grant  and
Robert F. Miller
George Mochloulis*
Affiliation:
Department of Otolaryngology, University College London Hospitals (NHS) Trust, UCLMS Middlesex Hospital Site, Mortimer Street, London, UK
Richard M. Irving
Affiliation:
Department of Otolaryngology, University College London Hospitals (NHS) Trust, UCLMS Middlesex Hospital Site, Mortimer Street, London, UK
Henry R. Grant
Affiliation:
Department of Otolaryngology, University College London Hospitals (NHS) Trust, UCLMS Middlesex Hospital Site, Mortimer Street, London, UK
Robert F. Miller
Affiliation:
Division of Pathology and Infectious Diseases, UCLMS Middlesex Hospital Site, Mortimer Street, London, UK
*
Address for correspondence: Dr D. Mochloulis, 8 Brendon Villas, Highfield Road, Winchmore Hill, London N21 3HP.
Get access Rights & Permissions [Opens in a new window]

Abstract

Over a period of 10 years 17 human immunodeficiency virus(HIV)-infected patients with laryngeal Kaposi's sarcoma were seen and treated at University College London Hospitals. All patients had advanced HIV disease. Their presentation was with symptoms of upper airway obstruction in the majority of cases and the diagnosis was made by fibreoptic examination of the larynx. Biopsy was associated with brisk haemorrhage in one patient, who required a temporary tracheostomy, and was not performed in the other 16 cases. The commonest site of laryngeal involvement was the supraglottis in 11 patients, with glottic lesions noted in eight patients: subglottic lesions were seen in only three. Treatment of laryngeal Kaposi's sarcoma was, in general, conservative, five patients received low dose radiotherapy to the larynx and 10 were treated with systemic chemotherapy for disseminated Kaposi's sarcoma. Laryngeal Kaposi's sarcoma did not contribute to patient mortality.

Keywords

SarcomaKaposi'sLaryngeal neoplasmsAcquired immunodeficiency syndromeHIV infectionsRadiotherapyDrug therapy

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 11 , November 1996 , pp. 1034 - 1037
Copyright
Copyright © JLO (1984) Limited 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Abemayor, E., Calcaterra, T. C. (1983) Kaposi's sarcoma and community-acquired immune deficiency syndrome. Archives of Otolaryngology 109: 536–542.CrossRefGoogle ScholarPubMed
Ambrosiak, J. A., Blackbourn, D. J., Herndier, B. G., Glogau, R. G., Gullett, J. H., McDonald, A. R., Lennette, E. T., Levy, J. A. (1995) Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients. Science 268: 582–583.CrossRefGoogle Scholar
Chang, Y., Cesarman, E., Pessin, M. S., Lee, F., Culpepper, J., Knowles, D. M, Moore, P. S. (1994) Identification of herpes-virus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266: 186–189.CrossRefGoogle Scholar
Coyas, A., Eliadellis, E., Anastassides, O. (1993) Kaposi's sarcoma of the larynx. Journal of Laryngology and Otology 97: 647–649.CrossRefGoogle Scholar
Friedman-Klein, A. E., Laubenstein, L. J., Marmor, M. (1981) Kaposi's sarcoma and pneumocystis pneumonia in New York and San Francisco. Morbid Mortal Weekly Report 35: 334–339.Google Scholar
Gill, P. S., Akil, B., Colletti, P., Rarick, M., Loureiro, C., Bernstein-Singer, M., Krailo, M., Levine, A. M. (1989) Pulmonary Kaposi's sarcoma: clinical findings and results of therapy. American Journal of Medicine 87: 57–61.CrossRefGoogle ScholarPubMed
Greenberg, J. G., Fischl, M. A., Berger, J. R. (1985) Upper airway obstruction secondary to acquired immunodeficiency syndrome-related Kaposi's sarcoma. Chest 88: 638–640.CrossRefGoogle ScholarPubMed
Hebeda, K. M., Huizing, M. T., Brouwer, P. A., van der Meulen, F. W., Hulsebosch, H. J., Reiss, P., Oosting, J., Veenhof, C. H. N., Bakker, P. J. M. (1995) Photodynamic therapy in AIDS-related cutaneous Kaposi's sarcoma. Journal of Acquired Immune Deficiency Syndrome 10: 61–70.Google ScholarPubMed
Howard, M., Brink, N., Miller, R., Tedder, R. (1995) Association of human herpesvirus with pulmonary Kaposi's sarcoma. Lancet 346: 712.CrossRefGoogle ScholarPubMed
Kaposi, M. (1872) Idiopathisehes multiples pigmensarkom der haut. Archives of Dermatology and Syphilogy 4: 265–273.CrossRefGoogle Scholar
Levy, F. E., Tansek, K. M. (1990) AIDS-associated Kaposi's sarcoma of the Larynx. Ear Nose and Throat Journal 69: 177–184.Google ScholarPubMed
Oettle, A. G. (1962) Geographical and racial differences in the frequency of Kaposi sarcoma as evidence of environmentalor genetic causes. Acta un int Cancer 18: 330–363.Google ScholarPubMed
Meduri, G. U., Stover, D. E., Lee, M., Myskowski, P. L., Caravelli, J. F., Zaman, M. B. (1986) Pulmonary Kaposi's sarcoma in the Acquired Immune Deficiency Syndrome. American Journal of Medicine 81: 11–18.CrossRefGoogle ScholarPubMed
Pitchenik, A. E., Fischl, M. A., Saldana, M. J. (1985) Kaposi's sarcoma of the tracheo bronchial tree clinical, bronchoscopic and pathologic features. Chest 87: 122–124.CrossRefGoogle ScholarPubMed
Simpson, J. K., Miller, R. F., Spittle, M. F. (1993) Liposomal doxorubicin for treatment of AIDS-related Kaposi's sarcoma. Clinical Oncology 5: 372–374.CrossRefGoogle ScholarPubMed
Stafford, N. D., Herdman, R. C. D., Forster, S., Munro, A. J. (1989) Kaposi's sarcoma of the head and neck in patients with AIDS. Journal of Laryngology and Otology 103: 379–382.CrossRefGoogle ScholarPubMed
Tami, T. A., Sharma, P. K. (1995) Intralesional vinblastine therapy for Kaposi's sarcoma of the epiglottis. Otolaryngology, Head and Neck Surgery 113: 282–285.CrossRefGoogle ScholarPubMed
Webster, G. F., Cockerell, C. J., Friedman-Klien, A. E. (1992) The clinical spectrum of bacilliary angiomatosis. British Journal of Dermatology 126: 535–541.CrossRefGoogle Scholar
Zibrak, J. D., Silvestri, R. C., Costello, P., Marlink, R., Jensen, W. A., Robins, A., Rose, R. M. (1986) Bronchoscopic and radiologic features of Kaposi's sarcoma involving the respiratory system. Chest 90: 476–479.CrossRefGoogle ScholarPubMed