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Preliminary report of associated factors in wound infection after major head and neck neoplasm operations — does the duration of prophylactic antibiotic matter?

Published online by Cambridge University Press:  20 April 2007

S-A Liu ,
K-C Tung ,
J-Y Shiao  and
Y-T Chiu
S-A Liu
Affiliation:
Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan
K-C Tung
Affiliation:
Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
J-Y Shiao
Affiliation:
Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan
Y-T Chiu*
Affiliation:
Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan
*
Address for correspondence: Y-T Chiu, Department of Education and Research, Taichung Veterans General Hospital, No. 160 Sec. 3, Chung-Kang Road, Taichung, Taiwan. Fax: 886 4 23596868 E-mail: an1654@seed.net.tw
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Abstract

The aim of this study was to investigate whether an extended course of prophylactic antibiotic could reduce the wound infection rate in a subtropical country. Fifty-three consecutive cases scheduled to receive major head and neck operations were randomised into one-day or three-day prophylactic antibiotic groups. Thirteen cases (24.5 per cent) developed wound infections after operations. The duration of prophylactic antibiotic was not related to the surgical wound infection. However, pre-operative haemoglobulin less than 10.5 g/dl (odds ratio: 7.24, 95 per cent confidence interval: 1.28–41.0) and reconstruction with a free flap or pectoris major myocutaneous flap during the operation (odds ratio: 11.04, 95 per cent confidence interval: 1.17–104.7) were associated factors significantly influencing post-operative wound infection. Therefore, one day of prophylactic antibiotic was effective in major head and neck procedures but should not be substituted for proper aseptic and meticulous surgical techniques.

Keywords

Head and Neck NeoplasmsWound InfectionProphylactic AntibioticsOtorhinolaryngological Surgical Procedures

Information

Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 4 , April 2008 , pp. 403 - 408
Copyright
Copyright © JLO (1984) Limited 2007

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