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Laryngeal dysplasia: relationship between anterior commissure involvement and progression to invasive cancer

Published online by Cambridge University Press:  01 August 2025

Ebru Karakaya Gojayev ,
Zahide Çiler Büyükatalay Yaldız Open the ORCID record for Zahide Çiler Büyükatalay Yaldız [Opens in a new window] ,
Gürsel Dursun  and
Kürşat Gökcan Open the ORCID record for Kürşat Gökcan [Opens in a new window]
Ebru Karakaya Gojayev
Affiliation:
Department of Otorhinolaryngology, Sincan Education and Research Hospital, Ankara, Turkey
Zahide Çiler Büyükatalay Yaldız
Affiliation:
Department of Otorhinolaryngology, Ankara University, Medical School, Ankara, Turkey
Gürsel Dursun
Affiliation:
Department of Otorhinolaryngology, Ankara University, Medical School, Ankara, Turkey
Kürşat Gökcan*
Affiliation:
Department of Otorhinolaryngology, Ankara University, Medical School, Ankara, Turkey
*
Corresponding author: Kürşat Gökcan; Email: kgokcan@gmail.com
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Abstract

Objectives

Laryngeal dysplasia is a pre-cancerous lesion within the larynx. This study aims to identify factors influencing progression to cancer by analysing long-term follow-up data.

Methods

Data from 221 patients diagnosed between 2005 and 2017 were reviewed retrospectively. Patient demographics, treatment strategies and follow-up results were compared.

Results

Progression to cancer occurred in 26 patients (11.7 per cent). A significant association was found between cancer progression and initial biopsies obtained from the anterior commissure (34.6 per cent in progressing cases vs. 6.2 per cent in non-progressing; p < 0.001). Carcinoma in situ cases showed a higher progression rate (21.7%) compared to mild dysplasia (3.4 per cent) (p = 0.007). The group with cancer progression also had higher rates of other cancers (15.4 per cent vs. 2.1 per cent; p = 0.008), including lung cancer (11.5 per cent vs. 0 per cent; p = 0.001).

Conclusion

The study determined an 11.7 per cent progression rate of laryngeal dysplasia to cancer. Lesions involving the anterior commissure carried an approximately 8.1-fold increased risk of progression.

Keywords

cancerchemoradiotherapydysphonialarynxvoice

Information

Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 139 , Issue 10 , October 2025 , pp. 923 - 927
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED.

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Footnotes

Mustafa Kürşat Gökcan takes responsibility for the integrity of the content of the paper

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