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Does HMGB1 predict occult neck lymph node metastasis in early tongue carcinoma? A case–control study of 26 patients

Published online by Cambridge University Press:  17 September 2014

H Hanakawa ,
Y Orita ,
Y Sato ,
M Takeuchi ,
S Takao ,
K Ohno ,
T Kohno ,
N Iwaki ,
H Marunaka  and
R Tamamura
...Show all authors
H Hanakawa
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
Y Orita*
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
Y Sato
Affiliation:
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
M Takeuchi
Affiliation:
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
S Takao
Affiliation:
Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
K Ohno
Affiliation:
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
T Kohno
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
N Iwaki
Affiliation:
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
H Marunaka
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Okayama Medical Center, Japan
R Tamamura
Affiliation:
Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
M Nishibori
Affiliation:
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
H Nagatsuka
Affiliation:
Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
K Nishizaki
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
T Yoshino
Affiliation:
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
*
Address for correspondence: Dr Yorihisa Orita, Department of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Kita-Ku, 700-8558 Okayama, Japan Fax: (+81)-86-235-7308 E-mail: y.orita@live.jp
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Abstract

Objective:

This study examined whether the occurrence of late neck metastasis in early tongue squamous cell carcinoma can be predicted by evaluating HMGB1 (high mobility group box 1) expression in the primary lesion.

Methods:

A case–control study was conducted. The cases comprised 10 patients with late neck metastasis. The controls consisted of 16 patients without recurrence. All were examined immunohistochemically for HMGB1 protein expression. The odds ratio for late neck metastasis in relation to HMGB1 was estimated.

Results:

Results for HMGB1 were dichotomised into positive staining scores (score, 5–7) and negative scores (0–4). Six cases (60 per cent) and four controls (25 per cent) were HMGB1-positive. Although no significant result was seen, compared with HMGB1-negative patients the odds ratio for late neck metastasis in HMGB1-positive patients was 3.8 (95 per cent confidence interval, 0.6–26.5) after adjusting for other factors.

Conclusion:

In the present study, immunohistochemical study of HMGB1 in early tongue squamous cell carcinoma did not appear to be very useful for predicting occult neck metastasis. Further study is necessary to clarify the relationship between HMGB1 expression and late neck metastasis in early tongue squamous cell carcinoma.

Keywords

HMGB1TongueCarcinomaMetastasis

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 128 , Issue 10 , October 2014 , pp. 926 - 931
Copyright
Copyright © JLO (1984) Limited 2014 

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Footnotes

Presented at the 37th annual meeting of the Japan Head and Neck Cancer Society, 13–14 June 2013, Tokyo, Japan.

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