Hostname: page-component-699b5d5946-jpxmw Total loading time: 0 Render date: 2026-03-02T23:14:18.158Z Has data issue: false hasContentIssue false
  • English
  • Français

Nasal muco-ciliary clearance in snuff users

Published online by Cambridge University Press:  29 June 2007

Shashi Chetan
Shashi Chetan*
Affiliation:
Karnataka, India
*
Dr Shashi Chetan, M.S., D.N.B., Lecturer, Dept. of Otolaryngology, Dr T. M. A. Pai Rotary Hospital (a unit of Kasturba Medical College), Bejai, Mangalore–575 004, Karnataka, India.
Get access Rights & Permissions [Opens in a new window]

Abstract

The inhalation of nasal snuff (powdered tobacco) is widely prevalent in the Indian sub-continent. The effect of snuff application on the nasal mucociliary clearance (NMMC) time has been suspected but not demonstrated before. In this study the saccharin test is used to demonstrate the rate of nasal mucociliary clearance among chronic snuff users. The study demonstrates the depressant action of snuff on the nasal mucociliary clearance rate. A pharmacological and pathological basis for the depressant action of snuff on the NMMC rate is hypothesised on the basis of the results obtained.

Keywords

TobaccosmokelessMucociliary clearanceSaccharintest

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 1 , January 1993 , pp. 24 - 26
Copyright
Copyright © JLO (1984) Limited 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Auerbach, O., Stout, A.P., Hammond, E. C., Garfinkel, L. (1962) Changes in bronchial epithelium in relation to sex, age, residence, smoking and pneumonia. New England Journal of Medicine 267: 111–119.CrossRefGoogle ScholarPubMed
Bhide, S. V., Kulkarni, J. R., Padma, P. R., Amonkar, A. J., Maru, G. B., Nair, U. J., Nair, J. (1989) Studies on tobacco specific nitrosamines and other carcinogenic agents in smokeless tobacco products. In Tobacco and Health: The Indian Scene (Sanghvi, L. D. and Notani, P. eds.) UICC Workshop, Tata Memorial Centre, Bombay, p 121–131.Google Scholar
Dalhamn, T. (1966) Effect of cigarette smoke on ciliary activity. American Review of Respiratory Diseases, 93: 108–114.Google ScholarPubMed
Ide, G.Suntzeff, V., Cowdry, E. V. (1959) A comparison of the histopathology of tracheal and bronchial epithelium of smokers and non-smokers. Cancer, 12: 473–484.3.0.CO;2-Q>CrossRefGoogle Scholar
Jaffe, J. H. (1990) Drug addiction and drug abuse. In Goodman and Gilmans, The Pharmacological Basis of Therapeutics. 8th edition (Gilman, A. G., Rail, T. W., Nies, A. S., Taylor, P. eds.) Pergamon Press, New York, p 522–573.Google Scholar
Kensler, C. J., Battista, S. P. (1963) Components of cigarette smoke with ciliary depressant activity. New England Journal of Medicine, 269: 1161–1166.CrossRefGoogle ScholarPubMed
Procter, D. F.Andersen, I., Lundqvist, G. (1979) Clearance of inhaled particles from the human nose. Archives of Internal Medicine, 131: 132–139.CrossRefGoogle Scholar
Sanghvi, L. D. (1989) Tobacco related cancers. In Tobacco and Health: The Indian Scene (Sanghvi, L. D. and Notani, P. eds.) UICC Workshop, Tata Memorial Centre, Bombay, p 9–15.Google Scholar
Stanley, P., MacWilliam, L., Greenstone, M., Mackay, I., Cole, P. (1984) Efficacy of a saccharin test for screening to detect abnormal muco-ciliary clearance. British Journal for Diseases of Chest, 78: 62–65.CrossRefGoogle Scholar