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Diagnostic importance of the nucleolar organizer regions in Wegener's granulomatosis

Published online by Cambridge University Press:  29 June 2007

Wen L. Yue ,
Zheng Z. Ma  and
Zhi H. Sun
Wen L. Yue*
Affiliation:
Department of Otolaryngology, Pingdingshan People's HospitalNo. 1, Henan, People's Republic of China.
Zheng Z. Ma
Affiliation:
Department of Otolaryngology, Pingdingshan People's HospitalNo. 1, Henan, People's Republic of China.
Zhi H. Sun
Affiliation:
Department of Otolaryngology, Pingdingshan People's HospitalNo. 1, Henan, People's Republic of China.
*
Address for correspondence: Wen L. Yue, M.D., Department of Otolaryngology, Pingdingshan People's Hospital No. 1, Henan 467000, People's Republic of China.
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Abstract

The number and distribution pattern of silver staining nucleolar organizer regions (AgNORs) were thought to reflect the cellular proliferative activity and the malignancy of tumours. Using a silver-staining method, the variations of AgNORs have been studied in patients with atypical inflammatory lesion (n = 5), malignant reticulosis (n = 5) and Wegener's granulomatosis (n = 6). Our results reveal that there was a statistically significant difference (p<0.01), highly suggestive of a difference in AgNOR counts between the atypical inflammatory lesion and Wegener's granulomatosis, with the Wegener's granulomatosis specimens having the higher irregular AgNORs, but the difference between Wegener's granulomatosis and malignant reticulosis is probably not clinically important. It is concluded that AgNORs may be useful in differentiating Wegener's granulomatosis from an atypical inflammatory lesion, and the simplified counting technique is adequate for the purpose.

Keywords

Wegener's granulomatosisNucleolus organizer regionSilver staining
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 111 , Issue 9 , September 1997 , pp. 825 - 828
Copyright
Copyright © JLO (1984) Limited 1997

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References

Buys, C. H. C. H., Osinga, J. (1984) Selective staining of the same set of nucleolar phosproteins by silver and Giemsa. Chromosoma 89: 387–396.CrossRefGoogle ScholarPubMed
Carbajo, S., Orfao, A., Vicente Villardon, J. L. (1993) Expression of silver-stained nucleolar organizer regions is coupled to cell cycle in rat thymic cells. Cytometry 14: 46–52.CrossRefGoogle ScholarPubMed
Clark, M. W., Yip, M. L. R., Campbell, S. (1990) SSB-1 of the yeast Saccharomyces cerevisiae is a nucleolar-specific, silverbinding protein that is associated with the SnR 10 and SnR 11 small nucleolar RNAs. Journal of Cell Biology 111(5): 1741–1751.CrossRefGoogle Scholar
Crocker, J., Nar, P. (1987) Nucleolar organizer regions in lymphomas. Journal of Pathology 151: 111–118.CrossRefGoogle ScholarPubMed
Crocker, J., Skilbeck, N. (1987) Nucleolar organizer region associated proteins in cutaneous melanotic lesions. Journal of Clinical Pathology 40: 885–889.CrossRefGoogle Scholar
Delahunt, B., Mostonfi, F. K., Sesterhenn, I. A. (1990) Nucleolar organizer regions in seminoma and intralobular malignant germ cells. Modern Pathology 3: 141–145.Google Scholar
Dervan, P. A., Gilmartin, L. C. (1989) Argyrophic nucleolar organizer region counts correlated with Ki-67 score. American Journal of Cell Pathology 92: 401–407.Google Scholar
Friedmann, I. (1982) McBride and the midfacial granuloma syndrome. Journal of Laryngology and Otology 96: 1–23.CrossRefGoogle ScholarPubMed
Gee, M. S., DuCanto, J., Caldarelli, D. D. (1992) Nucleolar organizer regions in paragangliomas of the head and neck. Archives of Otolaryngology – Head and Neck Surgery 118: 380–382.CrossRefGoogle ScholarPubMed
Gephardt, G. N., Shah, L. F., Tubbs, R. R. (1990) Wegener's granulomatosis: immunomicroscopic and ultrastructural study of four cases. Archives of Pathology, Laboratory and Medicine 114: 961–965.Google ScholarPubMed
Hernadez-Verdun, D. (1983) The nucleolar organizer regions. Biology of the Cell 49: 191–202.Google Scholar
Hirsch, S. M., DuCanto, J., Caldarelli, D. D. (1992) Nucleolar organizer regions in squamous cell carcinoma of the head and neck. Laryngoscope 102: 39–44.CrossRefGoogle ScholarPubMed
Ilium, T., Thorling, K. (1981) Wegener's granulomatosis: longterm results of treatment. Annals of Otology, Rhinology and Laryngology 90: 231–235.CrossRefGoogle Scholar
Kornblut, A. D., Wolff, S. M., DeFries, H. O. (1980) Wegener's granulomatosis. Laryngoscope 90: 1453–1463.CrossRefGoogle ScholarPubMed
Meyer, J., McDivitt, R. W. (1986) Reliability and stability of the thymidine labeling index of breast cancer. Laboratory Investigation 54: 160–164.Google Scholar
Peebles, S. E., McNicol, A. M. (1989) AgNOR number in rat pituitary corticotrophs following adrenalectomy or corticotrophin releasing factors administration. Virchow's Archives of Pathology B57: 209–212.CrossRefGoogle Scholar
Ploton, D., Menager, M., Jeannesson, D. (1986) Improvement in the staining and visualization of the argyrophilic proteins of the nucleolar organizer region at the optical level. Histochemistry 18: 5–14.CrossRefGoogle ScholarPubMed
Raymond, W. A., Leong, A. S. Y. (1989) Nucleolar organizer regions related to growth fractions in human carcinoma. Human Pathology 20: 741–746.CrossRefGoogle Scholar
Shibuya, M., Ito, S., Miwa, T. (1993) Proliferative potential of brain tumor. Cancer 111 199–206.3.0.CO;2-S>CrossRefGoogle Scholar
Smetana, K., Likovsky, Z. (1984) Nucleolar silver-stained granule in maturing erythroid and granulocytic cells. Cell and Tissue Research 237: 367–370.CrossRefGoogle ScholarPubMed
Smith, P. J., Skilbeck, N., Harrison, A. (1988) The effect of a series of fixation on the AgNOR technique. Journal of Pathology 155: 109–112.CrossRefGoogle ScholarPubMed
Trere, D., Pession, A., Derenzini, M. (1989) The silverstaining protein of interphasic nucleolar organizer regions as a parameter of cell duplication rate. Experimental Cellular Research 184: 131–137.CrossRefGoogle ScholarPubMed
Van Diest, P. J., Mouriquand, S., Schipper, N. M. (1990) Prognostic value of nucleolar morphometric variable in cytological breast cancer specimens. Journal of Clinical Pathology 43: 157–159.CrossRefGoogle ScholarPubMed
Viera, R., Rueiroz, A., Viegas, W. (1990) Visualization of nucleolar organizer regions in nucleoli of interphase plant cells. Cytologia 55: 339–347.CrossRefGoogle Scholar
White, R., Abreo, K., Veillon, D. (1992) Rapidly progressic crescentic glomerulonephritis associated with ANCA. Journal of Lake States Medical Society 144: 501–507.Google ScholarPubMed