Hostname: page-component-89b8bd64d-j4x9h Total loading time: 0 Render date: 2026-05-08T08:28:17.542Z Has data issue: false hasContentIssue false
  • English
  • Français

Changes in renal function in valvular and coronary patients

Published online by Cambridge University Press:  01 November 2007

G. Lema ,
W. Merino  and
C. Salinas
G. Lema*
Affiliation:
Department of AnesthesiologyPontificia Universidad Católica de ChileSantiago, Chile
W. Merino
Affiliation:
Department of AnesthesiologyPontificia Universidad Católica de ChileSantiago, Chile
C. Salinas
Affiliation:
Department of AnesthesiologyPontificia Universidad Católica de ChileSantiago, Chile
*
Correspondence to: Guillermo Lema, Department of Anesthesiology, Pontificia Universidad Católica de Chile, Santiago, Chile. E-mail: glema@med.puc.cl; Tel: +56(2) 6863415; Fax: +56(2) 6394409

Abstract

An abstract is not available for this content. As you have access to this content, full HTML content is provided on this page. A PDF of this content is also available in through the ‘Save PDF’ action button.

Information

Type
Correspondence
Information
European Journal of Anaesthesiology , Volume 24 , Issue 11 , November 2007 , pp. 984 - 985
Copyright
Copyright © European Society of Anaesthesiology 2007

EDITOR:

I read with interest the article by Landoni and colleagues [Reference Landoni, Roberti and Boroli1] regarding acute renal failure and mitral valve surgery. Acute renal failure is one of the most serious complications of cardiac surgery, with high morbidity and mortality, although the subject is still not completely understood. Most of the research related to valve surgery and cardiopulmonary bypass (CPB) is from the 1960s and 1970s [Reference Porter, Kloster and Herr2,Reference Porter, Kloster and Herr3]. The current practice of valve surgery, recent development in CPB and new postoperative strategies offers us a different situation.

Early work in valvular surgery patients stated that CPB was the main cause of renal dysfunction and acute renal failure. There are a number of papers, showing that, contrary to this belief, CPB is not the main cause of this morbidity. However, most of this work has been performed in patients undergoing coronary artery surgery [Reference Lema, Meneses and Urzua4,Reference Lema, Urzúa and Jalil5].

A recent study by our group (unpublished results) [6] shows that in valvular surgery patients (mitral and aortic valve), the pattern of renal function during CPB, studied with inulin infusion for glomerular filtration rate (GFR) and I131 Hipuran for effective renal plasma flow (ERPF) is well preserved and no differences were found when compared with our own earlier studies in coronary patients [Reference Lema, Meneses and Urzua4,Reference Lema, Urzúa and Jalil5] (Fig. 1). To our knowledge, that was the first such study in valvular surgery patients. GFR and ERPF were well preserved throughout, but ERPF was reduced before surgery. Similar results have been found in others types of surgery [Reference Colson, Ribstein and Seguin7].

Figure 1

Renal function during cardiopulmonary bypass. GFR: glomerular filtration rate; ERPF: effective renal plasma flow; ECC: extracorporeal circulation; h: hypothermia; n: normothermia; post-op: postoperative.

We agree with Landoni and colleagues that the risk for renal dysfunction and acute renal failure depends on many other factors: fasting, hypovolaemia, low cardiac output, emergencies, bleeding and preoperative renal dysfunction. Perioperative factors other than CPB should be considered the main reasons for acute renal failure in patients undergoing coronary and valvular surgery.

References

1.Landoni, G, Roberti, A, Boroli, F et al. . Mitral valve surgery and acute failure. Eur J Anesthesiol 2006; 24: 100–101.CrossRefGoogle Scholar
2.Porter, GA, Kloster, FE, Herr, RJ et al. . Renal complications associated with valve replacement surgery. J Thorac Cardiovasc Surg 1967; 53: 145–152.CrossRefGoogle ScholarPubMed
3.Porter, GA, Kloster, FE, Herr, RJ et al. . Relationship between alterations in renal hemodynamics during cardiopulmonary bypass and postoperative renal function. Circulation 1966; 34: 1005–1021.CrossRefGoogle ScholarPubMed
4.Lema, G, Meneses, G, Urzua, J et al. . Effects of extracorporeal circulation on renal function in coronary surgical patients. Anesth Analg 1995; 81: 446–451.Google ScholarPubMed
5.Lema, G, Urzúa, J, Jalil, R et al. . Renal protection in patients undergoing cardiopulmonary bypass with preoperative abnormal renal function. Anesth Analg 1998; 86: 3–8.CrossRefGoogle ScholarPubMed
6. Lema G, Canessa R, Carvajal C et al. Renal function in valvular and coronary patients undergoing surgery with extracorporeal circulation. Abstract. 29th Annual Meeting & Workshops, Society of Cardiovascular Anesthesiologist, Montreal, Canada, 2007.Google Scholar
7.Colson, P, Ribstein, J, Seguin, JR et al. . Mechanisms of renal hemodynamic impairment during infrarenal aortic cross-clamping. Anesth Analg 1993; 76 (2): 458–460.Google Scholar
Figure 0

Figure 1 Renal function during cardiopulmonary bypass. GFR: glomerular filtration rate; ERPF: effective renal plasma flow; ECC: extracorporeal circulation; h: hypothermia; n: normothermia; post-op: postoperative.