Hostname: page-component-6766d58669-kl59c Total loading time: 0 Render date: 2026-05-19T16:45:50.483Z Has data issue: false hasContentIssue false
  • English
  • Français

The effects of peracetic acid solution on the treatment of otomycosis in an animal model: a new antifungal drug?

Published online by Cambridge University Press:  15 December 2022

S Nemati ,
M Akbarpour ,
E Lotfali ,
R Nosrati ,
E Rafiee  and
N Zebardast Open the ORCID record for N Zebardast [Opens in a new window]
S Nemati
Affiliation:
Otorhinolaryngology Research Center, Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
M Akbarpour
Affiliation:
Otorhinolaryngology Research Center, Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
E Lotfali
Affiliation:
Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
R Nosrati
Affiliation:
Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
E Rafiee
Affiliation:
Razi Clinical Research Development Unit, Guilan University of Medical Sciences, Rasht, Iran
N Zebardast*
Affiliation:
Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
*
Author for correspondence: Dr N Zebardast, Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, 6th Kilometer of Rasht-Tehran Highway, Rasht 41937-1311, Iran E-mail: nszebardast@gmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

This study aimed to investigate the therapeutic effects of 1 per cent and 0.01 per cent peracetic acid as an antifungal agent in animal otomycosis.

Method

After creating a superficial scratch in the external auditory canal of guinea pigs, a suspension of Aspergillus niger, Aspergillus fumigatus and candida were inoculated into the ears of the animals. After otomycosis, the effect of 1 per cent or 0.01 per cent peracetic acid on otomycosis was evaluated by otomicroscopy and culture at 10 days post-treatment and compared with 2 per cent acetic acid as the control.

Results

A 10-day treatment with 1 per cent peracetic acid and 2 per cent acetic acid (control) showed normal otomicroscopy and negative cultures compared with 0.01 per cent peracetic acid. Drug sedimentation or other side effects in the external auditory canal or tympanic membrane were not observed during treatment with peracetic acid.

Conclusion

The findings of this study confirm that the treatment of otomycosis with 1 per cent peracetic acid in an animal model is beneficial and may be a novel therapeutic treatment for otomycosis.

Keywords

OtomycosisPeracetic AcidAcetic AcidGuinea Pigs

Information

Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 137 , Issue 7 , July 2023 , pp. 799 - 803
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

Footnotes

Dr N Zebardast takes responsibility for the integrity of the content of the paper

References

Nemati, S, Hassanzadeh, R, Jahromi, SK, Abadi, ADN. Otomycosis in the north of Iran: common pathogens and resistance to antifungal agents. Eur Arch Otorhinolaryngol 2014;271:953–710.1007/s00405-013-2486-0CrossRefGoogle ScholarPubMed
Munguia, R, Daniel, SJ. Ototopical antifungals and otomycosis: a review. Int J Pediatr Otorhinolaryngol 2008;72:453–910.1016/j.ijporl.2007.12.005CrossRefGoogle ScholarPubMed
Vennewald, I, Klemm, E. Otomycosis: diagnosis and treatment. Clin Dermatol 2010;28:202–1110.1016/j.clindermatol.2009.12.003CrossRefGoogle ScholarPubMed
Gharaghani, M, Seifi, Z, Mahmoudabadi, AZ. Otomycosis in Iran: a review. Mycopathologia 2015;179:415–2410.1007/s11046-015-9864-7CrossRefGoogle ScholarPubMed
Jia, X, Liang, Q, Chi, F, Cao, W. Otomycosis in Shanghai: aetiology, clinical features and therapy. Mycoses 2012;55:404–910.1111/j.1439-0507.2011.02132.xCrossRefGoogle ScholarPubMed
Bineshian, F, Irajian, GR, Fredonian, M. A study on the frequency of fungal agents in otitis externa in Semnan. Iran J Pathol 2006;1:141–4Google Scholar
Viswanatha, B, Naseeruddin, K. Fungal infections of the ear in immunocompromised host: a review. Mediterr J Hematol Infect Dis 2011;3:e201100310.4084/mjhid.2011.003CrossRefGoogle ScholarPubMed
Kitis, M. Disinfection of wastewater with peracetic acid: a review. Environ Int 2004;30:47–5510.1016/S0160-4120(03)00147-8CrossRefGoogle ScholarPubMed
Kim, J, Huang, C-H. Reactivity of peracetic acid with organic compounds: a critical review. ACS ES&T Water 2021;1:15–3310.1021/acsestwater.0c00029CrossRefGoogle Scholar
Shahbaz, B, Norouzi, M, Tabatabai, H. Mechanism of action and application of virocids in health care associated viral infections. Tehran Univ Med J 2016;73:837–55Google Scholar
Costa, SAdS, Paula, OFPd, Leão, MVP, Santos, SSFD. Stability of antimicrobial activity of peracetic acid solutions used in the final disinfection process. Braz Oral Res 2015;29:1–6Google ScholarPubMed
Yoganarasimha, S, Trahan, WR, Best, AM, Bowlin, GL, Kitten, TO, Moon, PC et al. Peracetic acid: a practical agent for sterilizing heat-labile polymeric tissue-engineering scaffolds. Tissue Eng Part C Methods 2014;20:714–2310.1089/ten.tec.2013.0624CrossRefGoogle ScholarPubMed
Hushangi, R, Hosseini Shekarabi, SP. Effect of a peracetic acid-based disinfectant on growth, hematology and histology of juvenile rainbow trout (Oncorhynchus mykiss). Fishes 2018;3:1–810.3390/fishes3010010CrossRefGoogle Scholar
Salihoglu, M, Dogru, S, Cesmeci, E, Caliskan, H, Kurt, O, Kuçukodaci, Z et al. Ototoxicity of boric acid powder in a rat animal model. Braz J Otorhinolaryngol 2018;84:332–710.1016/j.bjorl.2017.03.010CrossRefGoogle Scholar
Nemati, S, Gerami, H, Habibi, AF, Kazemnejad, E, Shabani, N, Aghsaghloo, V et al. Sertaconazole versus clotrimazole and miconazole creams in the treatment of otomycosis: a placebo-controlled clinical trial. Iran J Otorhinolaryngol 2022;34:27–34Google ScholarPubMed
Jackman, A, Ward, R, April, M, Bent, J. Topical antibiotic induced otomycosis. Int J Pediatr Otorhinolaryngol 2005;69:857–6010.1016/j.ijporl.2005.01.022CrossRefGoogle ScholarPubMed
Than, KM, Naing, KS, Min, M. Otomycosis in Burma, and its treatment. Am J Trop Med Hyg 1980;29:620–310.4269/ajtmh.1980.29.620CrossRefGoogle ScholarPubMed
Anwar, K, Gohar, MS. Otomycosis; clinical features, predisposing factors and treatment implications. Pak J Med Sci Q 2014;30:564Google ScholarPubMed
Ozcan, KM, Ozcan, M, Karaarslan, A, Karaarslan, F. Otomycosis in Turkey: predisposing factors, aetiology and therapy. J Laryngol Otol 2003;117:39–4210.1258/002221503321046621CrossRefGoogle ScholarPubMed
Erkan, M, Asian, T, Soyuer, O. Treatment of otomycosis with acetic acid and boric acid. Erciyes Tip Dergisi 1992;14:1–30Google Scholar
Yeganeh-Moghadam, A, Asadi, MA, Dehghani, R, Mahmoudabadi, AZ, Raygan, F, Hooshyar, H et al. Evaluating the effect of a mixture of alcohol and acetic acid for otomycosis therapy. Jundishapur J Microbiol 2010;3:66–70Google Scholar