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Early diagnosis and stage-adapted treatment of Wegener’s granulomatosis

Published online by Cambridge University Press:  10 May 2006

G. Cadoni ,
S. Agostino ,
E. Campobasso ,
P. Vulpiani ,
R. Manna  and
J. Galli
G. Cadoni
Affiliation:
Institute of Otolaryngology, Catholic University of the Sacred Heart, Rome, Italy.
S. Agostino
Affiliation:
Institute of Otolaryngology, Catholic University of the Sacred Heart, Rome, Italy.
E. Campobasso
Affiliation:
Institute of Otolaryngology, Catholic University of the Sacred Heart, Rome, Italy.
P. Vulpiani
Affiliation:
Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy.
R. Manna
Affiliation:
Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy.
J. Galli
Affiliation:
Institute of Otolaryngology, Catholic University of the Sacred Heart, Rome, Italy.
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Abstract

A case of Wegener’s granulomatosis (WG) presenting with hearing loss and right facial nerve palsy is reported. The definitive diagnosis was based upon clinical data and serum cANCA and AECA detection. Early assessment of WG prevented surgical facial nerve decompression to treat a chronic otitis media complication. Immunosuppressive therapy with steroids, cyclophosphamide and methotrexate was required for relief of clinical symptoms and cANCA negativity as an expression of disease remission. The effectiveness of co-trimoxazole for preventing relapses of WG is discussed.

Keywords

Wegener’s GranulomatosisHearing LossBilateralAntibodiesAntineutrophil CytoplasmicFacial Paralysis
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 117 , Issue 3 , March 2003 , pp. 208 - 211
Copyright
© Royal Society of Medicine Press Limited 2003

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