Hostname: page-component-6766d58669-zlvph Total loading time: 0 Render date: 2026-05-17T03:14:18.587Z Has data issue: false hasContentIssue false
  • English
  • Français

Magnetic resonance imaging of Ménière's disease: early clinical experience in a UK centre

Published online by Cambridge University Press:  03 April 2020

I Pai ,
S Mendis ,
L Murdin ,
P Touska  and
S Connor
I Pai*
Affiliation:
Department of Otolaryngology, Guy's and St Thomas’ Hospital, London, UK
S Mendis
Affiliation:
Department of Otolaryngology, Guy's and St Thomas’ Hospital, London, UK
L Murdin
Affiliation:
Department of Otolaryngology, Guy's and St Thomas’ Hospital, London, UK
P Touska
Affiliation:
Department of Radiology, Guy's and St Thomas’ Hospital, London, UK
S Connor
Affiliation:
Department of Radiology, Guy's and St Thomas’ Hospital, London, UK School of Biomedical Engineering and Imaging Sciences Clinical Academic Group, King's College London, UK Department of Neuroradiology, Kings College Hospital, London, UK
*
Author for correspondence: Miss Irumee Pai, St Thomas’ Hearing Implant Centre, 2nd floor Lambeth Wing, St Thomas’ Hospital, Westminster Bridge Road, London SE1 7EH, UK E-mail: Irumee.Pai@gstt.nhs.uk Fax: +44 (0)20 7188 8905
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

Recent developments in magnetic resonance imaging have enabled demonstration of endolymphatic hydrops, and the clinical application of these imaging studies in Ménière's disease is being explored.

Objective

To evaluate our centre's experience to date of hydrops magnetic resonance imaging in patients with episodic vertigo.

Methods

Magnetic resonance imaging was performed using a high-resolution three-dimensional fluid-attenuated inversion recovery sequence on a 3 Tesla scanner at 4 hours following double-dose gadolinium administration.

Results

The study included 31 patients, 28 of whom had a clinical diagnosis of Ménière's disease. In unilateral Ménière's disease, magnetic resonance imaging was able to lateralise endolymphatic hydrops to the clinically symptomatic ear in all cases. Mild hydrops was often seen in clinically asymptomatic ears.

Conclusion

There is a good correlation between the clinical symptoms and lateralisation of hydropic changes on magnetic resonance imaging. Further refinements of imaging techniques and grading system will likely improve the diagnostic accuracy and clinical utilisation of hydrops magnetic resonance imaging.

Keywords

Magnetic Resonance ImagingMeniere's DiseaseEndolymphatic HydropsVertigo

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 134 , Issue 4 , April 2020 , pp. 302 - 310
Copyright
Copyright © JLO (1984) Limited, 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

Footnotes

Miss I Pai takes responsibility for the integrity of the content of the paper

References

Pyykko, I, Nakashima, T, Yoshida, T, Zou, J, Naganawa, S. Meniere's disease: a reappraisal supported by a variable latency of symptoms and the MRI visualisation of endolymphatic hydrops. BMJ Open 2013;14:3Google Scholar
Belinchon, A, Perez-Garrigues, H, Tenias, JM. Evolution of symptoms in Ménière's disease. Audiol Neurootol 2012;17:126–32CrossRefGoogle ScholarPubMed
Hallpike, GS, Cairns, H. Observations on the pathology of Meniere's syndrome. J Laryngol Otol 1938;53:625–55CrossRefGoogle Scholar
Lindsay, JR. Meniere's disease: histopathologic observations. Arch Otolaryngol 1944;39:313–18CrossRefGoogle Scholar
Lindsay, JR. Labyrinthine dropsy. Laryngoscope 1946;56:325–41Google ScholarPubMed
Lawrence, M, McCabe, BF. Inner ear mechanics and deafness: special consideration of Meniere's syndrome. J Am Med Assoc 1959;171:1927–32CrossRefGoogle ScholarPubMed
Schuknecht, HF, Benitez, JT, Beekhuis, J. Further observations on the pathology of Meniere's disease. Ann Otol Rhinol Laryngol 1962;71:1039–53CrossRefGoogle ScholarPubMed
Altmann, F, Kornfeld, M. Histological studies of Meniere's disease. Ann Otol Rhinol Laryngol 1965;74:915–43CrossRefGoogle ScholarPubMed
Rauch, SD, Merchant, SN, Thedinger, BA. Meniere's syndrome and endolymphatic hydrops: double-blind temporal bone study. Ann Otol Rhinol Laryngol 1989;98:873–83CrossRefGoogle ScholarPubMed
Merchant, SN, Adams, JC, Nadol, JB Jr. Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops? Otol Neurotol 2005;26:74–81CrossRefGoogle ScholarPubMed
Fraysse, BG, Alonso, A, House, WF. Meniere's disease and endolymphatic hydrops: clinical histopathological correlations. Ann Otol Rhinol Laryngol Suppl 1980;89:2–22CrossRefGoogle ScholarPubMed
Kariya, S, Cureoglu, S, Fukushima, H, Kusunoki, T, Schachern, PA, Nishizaki, K et al. Histopathologic changes of contralateral human temporal bone in unilateral Meniere's disease. Otol Neurotol 2007;28:1063–8CrossRefGoogle ScholarPubMed
Egami, N, Kakigi, A, Sakamoto, T, Takeda, T, Hyodo, M, Yamasoba, T. Morphological and functional changes in a new animal model of Ménière's disease. Lab Invest 2013;93:1001–11CrossRefGoogle Scholar
Kim, M, Kim, KS. Vestibular function change in a vasopressin-induced hydrops model. Otol Neurotol 2017;38:e495–500CrossRefGoogle Scholar
Foster, CA, Breeze, RE. Endolymphatic hydrops in Ménière's disease: cause, consequence, or epiphenomenon? Otol Neurotol 2013;34:1210–14CrossRefGoogle ScholarPubMed
Gibson, WPR, Moffat, DA, Ramsden, RT. Clinical electrocochleography in the diagnosis and management of Meniere's disorder. Audiology 1977;16:398–401Google Scholar
Hornibrook, J. Tone burst electrocochleography for the diagnosis of clinically certain Meniere's disease. Front Neurosci 2017;16:301CrossRefGoogle Scholar
Iseli, C, Gibson, WPR. A comparison of three methods of using transtympanic electrocochleography for the diagnosis of Meniere's disease: click summating potential measurements, tone burst summating potential measurements amplitude measures, and biasing of the summating potential with a low tone. Acta Otolaryngol 2010;130:95–101CrossRefGoogle Scholar
Nguyen, LT, Harris, JP, Nguyen, QT. Clinical utility of electrocochleography in the diagnosis and management of Ménière's disease: AOS and ANS membership survey data. Otol Neurotol 2010;31:455–9CrossRefGoogle ScholarPubMed
Nakashima, T, Naganawa, S, Sugiura, M, Teranishi, M, Sone, M, Hayashi, H et al. Visualization of endolymphatic hydrops in patients with Meniere's disease. Laryngoscope 2007;117:415–20CrossRefGoogle ScholarPubMed
Naganawa, S, Sugiura, M, Kawamura, M, Fukatsu, H, Sone, M, Nakashima, T. Imaging of endolymphatic and perilymphatic fluid at 3T after intratympanic administration of gadolinium-diethylene-triamine pentaacetic acid. Am J Neuroradiol 2008;29:724–6CrossRefGoogle ScholarPubMed
Naganawa, S, Yamazaki, M, Kawai, H, Bokura, K, Sone, M, Nakashima, T. Visualization of endolymphatic hydrops in Meniere's disease with single-dose intravenous gadolinium-based contrast media using heavily T(2)-weighted 3D-FLAIR. Magn Reson Med Sci 2010;9:237–42CrossRefGoogle Scholar
Naganawa, S, Nakashima, T. Visualization of endolymphatic hydrops with MR imaging in patients with Meniere's disease and related pathologies: current status of its methods and clinical significance. Jpn J Radiol 2014;32:191–204CrossRefGoogle ScholarPubMed
Barath, K, Schuknecht, B, Naldi, AM, Schrepfer, T, Bockisch, CJ, Hegemann, SC. Detection and grading of endolymphatic hydrops in Meniere's disease using MR imaging. AJNR Am J Neuroradiol 2014;35:1387–92CrossRefGoogle ScholarPubMed
Attye, A, Eliezer, M, Boudiaf, N, Tropres, I, Chechin, D, Schmerber, S et al. MRI of endolymphatic hydrops in patients with Meniere's disease: a case-controlled study with a simplified classification based on saccular morphology. Eur Radiol 2017;27:3138–46CrossRefGoogle ScholarPubMed
Nakashima, T, Naganawa, S, Katayama, N, Teranishi, M, Nakata, S, Sugiura, M et al. Clinical significance of endolymphatic imaging after intratympanic gadolinium injection. Acta Otolaryngol Suppl 2009;560:9–14CrossRefGoogle Scholar
Lopez-Escamez, JA, Carey, J, Chung, WH, Goebel, JA, Magnusson, M, Mandalà, M et al. Diagnostic criteria for Menière's disease. J Vestib Res 2015;25:1–7CrossRefGoogle ScholarPubMed
Naganawa, S, Yamazaki, M, Kawai, H, Sone, M, Nakashima, T. Contrast enhancement of the anterior eye segment and subarachnoid space: detection in the normal state by heavily T2-weighted 3D FLAIR. Magn Reson Med Sci 2011;10:193–9CrossRefGoogle ScholarPubMed
Sepahdari, AR, Ishiyama, G, Vorasubin, N, Peng, KA, Linetsky, M, Ishiyama, A. Delayed intravenous contrast-enhanced 3D FLAIR MRI in Meniere's disease: correlation of quantitative measures of endolymphatic hydrops with hearing. Clin Imaging 2015;39:26–31CrossRefGoogle ScholarPubMed
Sano, R, Teranishi, M, Yamazaki, M, Isoda, H, Naganawa, S, Sone, M et al. Contrast enhancement of the inner ear in magnetic resonance images taken at 10 minutes or 4 hours after intravenous gadolinium injection. Acta Otolaryngol 2012;132:241–6CrossRefGoogle ScholarPubMed
Tagaya, M, Yamazaki, M, Teranishi, M, Naganawa, S, Yoshida, T, Otake, H et al. Endolymphatic hydrops and blood-labyrinth barrier in Ménière's disease. Acta Otolaryngol 2011;131:474–9CrossRefGoogle ScholarPubMed
Yoshida, T, Sugimoto, S, Teranishi, M, Otake, H, Yamazaki, M, Naganawa, S et al. Imaging of the endolymphatic space in patients with Ménière's disease. Auris Nasus Larynx 2018;45:33–8CrossRefGoogle ScholarPubMed
Pakdaman, MN, Ishiyama, G, Ishiyama, A, Peng, KA, Kim, HJ, Pope, WB et al. Blood-labyrinth barrier permeability in Menière disease and idiopathic sudden sensorineural hearing loss: findings on delayed postcontrast 3D-FLAIR MRI. AJNR Am J Neuroradiol 2016;37:1903–8CrossRefGoogle ScholarPubMed
Ramalho, J, Semelka, RC, Ramalho, M, Nunes, RH, AlObaidy, M, Castillo, M. Gadolinium-based contrast agent accumulation and toxicity: an update. AJNR Am J Neuroradiol 2016;37:1192–8CrossRefGoogle ScholarPubMed
Eliezer, M, Poillon, G, Gillibert, A, Horion, J, Cruypeninck, Y, Gerardin, E et al. Comparison of enhancement of the vestibular perilymph between gadoterate meglumine and gadobutrol at 3-Tesla in Meniere's disease. Diagn Interv Imaging 2018;99:271–7CrossRefGoogle ScholarPubMed
Simon, F, Guichard, JP, Kania, R, Franc, J, Herman, P, Hautefort, C. Saccular measurements in routine MRI can predict hydrops in Menière's disease. Eur Arch Otorhinolaryngol 2017;274:4113–20CrossRefGoogle ScholarPubMed
Eliezer, M, Poillon, G, Horion, J, Lelion, P, Gerardin, E, Magne, N et al. MRI diagnosis of saccular hydrops: comparison of heavily-T2 FIESTA-C and 3D-FLAIR sequences with delayed acquisition. J Neuroradiol 2019. Epub 2019 Apr 26CrossRefGoogle ScholarPubMed
Phillips, JS, Murdin, L, Rea, P, Sutton, L. Clinical subtyping of Meniere's disease. Otolaryngol Head Neck Surg 2018;159:407–9CrossRefGoogle ScholarPubMed