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Sodium fluoride in otosclerosis treatment: review

Published online by Cambridge University Press:  18 February 2010

A S Cruise ,
A Singh  and
R E Quiney
A S Cruise*
Affiliation:
Department of Otolaryngology, Royal Free Hospital, London, UK
A Singh
Affiliation:
Department of Otolaryngology, Royal Free Hospital, London, UK
R E Quiney
Affiliation:
Department of Otolaryngology, Royal Free Hospital, London, UK
*
Address for correspondence: Mr A S Cruise, Department of Otolaryngology, Royal Free Hospital, 330 Gray's Inn Road, London WC1X 8DA, UK. Fax: 0207915 1430 E-mail: mr.andrew.cruise@gmail.com
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Abstract

Objectives:

To review the current literature on the use of sodium fluoride in the treatment of otosclerosis.

Design:

A literature review was conducted, searching the Medline and PubMed database from 1966 to 2009, using the terms ‘otosclerosis’ and ‘fluoride’. Article abstracts were reviewed and relevant full articles acquired.

Results:

There has been only one double-blind, placebo-controlled trial of the use of sodium fluoride in otosclerosis patients, and this found a reduced incidence of deterioration in hearing after two years in the treatment group. Several case–control series have described a hearing benefit in the sodium fluoride treated group. Treatment doses vary greatly, and there is no evidence regarding the optimum duration of treatment.

Conclusions:

There is low quality evidence suggesting that sodium fluoride may be of benefit to preserve hearing and reduce vestibular symptoms in patients with otosclerosis.

Keywords

OtosclerosisSodium FluorideHearing Loss

Information

Type
Review Articles
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 6 , June 2010 , pp. 583 - 586
Copyright
Copyright © JLO (1984) Limited 2010

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