Book contents
- Liver Disease in Children
- Liver Disease in Children
- Copyright page
- Contents
- Contributors
- Preface
- Section I Pathophysiology of Pediatric Liver Disease
- Chapter 1 Liver Development
- Chapter 2 Functional Development of the Liver
- Chapter 3 Mechanisms of Bile Formation and the Pathogenesis of Cholestasis
- Chapter 4 Acute Liver Failure in Children
- Chapter 5 Cirrhosis and Chronic Liver Failure in Children
- Chapter 6 Portal Hypertension in Children
- Chapter 7 Laboratory Assessment of Liver Function and Injury in Children
- Section II Cholestatic Liver Disease
- Section III Hepatitis and Immune Disorders
- Section IV Metabolic Liver Disease
- Section V Other Considerations and Issues in Pediatric Hepatology
- Index
- References
Chapter 1 - Liver Development
from Section I - Pathophysiology of Pediatric Liver Disease
Published online by Cambridge University Press: 19 January 2021
Book contents
- Liver Disease in Children
- Liver Disease in Children
- Copyright page
- Contents
- Contributors
- Preface
- Section I Pathophysiology of Pediatric Liver Disease
- Chapter 1 Liver Development
- Chapter 2 Functional Development of the Liver
- Chapter 3 Mechanisms of Bile Formation and the Pathogenesis of Cholestasis
- Chapter 4 Acute Liver Failure in Children
- Chapter 5 Cirrhosis and Chronic Liver Failure in Children
- Chapter 6 Portal Hypertension in Children
- Chapter 7 Laboratory Assessment of Liver Function and Injury in Children
- Section II Cholestatic Liver Disease
- Section III Hepatitis and Immune Disorders
- Section IV Metabolic Liver Disease
- Section V Other Considerations and Issues in Pediatric Hepatology
- Index
- References
Summary
The essential liver endocrine and exocrine functions require a precise spatial arrangement of the repeated hepatic lobule consisting of the central vein, portal vein, hepatic artery, intrahepatic bile duct system, and hepatocyte zonation. This allows (1) blood to be carried through the liver parenchyma and sampled by all hepatocytes, (2) hepatocytes to uptake metabolites and toxins from the blood for metabolizing and detoxification from their basal sinusoidal side, and (3) hepatocytes to produce and secrete bile from their apical canalicular side to be carried out of the liver through the biliary (i.e., intrahepatic bile duct) system composed of biliary epithelial cells (i.e., cholangiocytes).
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- Liver Disease in Children , pp. 1 - 11Publisher: Cambridge University PressPrint publication year: 2021
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