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The efficacy and safety of radiofrequency ablation for allergic rhinitis: a systematic review and meta-analysis

Published online by Cambridge University Press:  04 December 2024

Xi Zhang Open the ORCID record for Xi Zhang [Opens in a new window] ,
Min Yan ,
Qicheng Deng  and
Ling Yang
Xi Zhang
Affiliation:
Department of Otolaryngology Head and Neck Surgery of Nanchong Central Hospital, Nanchong, China
Min Yan
Affiliation:
Nanchong Central Hospital, Nanchong, China
Qicheng Deng
Affiliation:
Public Health Clinical Center of Chengdu, Chengdu, China
Ling Yang*
Affiliation:
Department of Otolaryngology Head and Neck Surgery of Dazhou Central Hospital, Dazhou, China
*
Corresponding author: Ling Yang; Email: 1019473909@qq.com
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Abstract

Objective

This systematic review aims to synthesise findings from randomised, controlled trials and assess the efficacy and safety of radiofrequency ablation in treating allergic rhinitis.

Methods

A thorough search was conducted across PubMed, the Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure, WanFang, Chinese Scientific Journal, and Chinese Biomedical Literature databases from their inception until October 2023. The primary outcome measure was the total effective rate, with secondary outcomes including adverse events.

Results

This review included 15 randomised, controlled trials involving 1430 patients. The pooled analysis revealed a statistically significant effect on the total effective rate (odds ratio = 3.27, 95 per cent confidence interval = 2.37 to ~4.51). However, no statistical significance was observed in adverse events (odds ratio = 1.18, 95 per cent confidence interval = 0.67 to ~2.08).

Conclusions

Based on the analytical results, radiofrequency ablation emerges as an efficacious and safe treatment modality for allergic rhinitis. Given the constraints posed by a limited sample size, it is imperative that forthcoming clinical trials adhere rigorously to the gold standard of randomised, controlled trials for the purpose of corroborating these conclusions.

Keywords

radiofrequency ablationallergic rhinitissystematic reviewmeta-analysis

Information

Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 138 , Issue 12 , December 2024 , pp. 1120 - 1129
Copyright
Copyright © The Author(s), 2024. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Ling Yang takes responsibility for the integrity of the content of the paper

References

Chong, SN, Chew, FT. Epidemiology of allergic rhinitis and associated risk factors in Asia. World Allergy Organ J 2018;11:17CrossRefGoogle ScholarPubMed
Zhang, Y, Zhang, L. Increasing prevalence of allergic rhinitis in China. Allergy Asthma Immunol Res 2019;11:156–69CrossRefGoogle ScholarPubMed
Leth-Møller, KB, Skaaby, T, Linneberg, A. Allergic rhinitis and allergic sensitisation are still increasing among Danish adults. Allergy 2020;75:660–8CrossRefGoogle ScholarPubMed
Brożek, JL, Bousquet, J, Agache, I, Agarwal, A, Bachert, C, Bosnic-Anticevich, S et al. Allergic rhinitis and its impact on asthma (ARIA) guidelines—2016 revision. J Allergy Clin Immunol 2017;140:950–8CrossRefGoogle ScholarPubMed
Yoo, SH, Choi, JH, Mo, JH. Long-term efficacy of turbinoplasty compared with medical treatment in patients with allergic rhinitis. Acta Otolaryngol 2022;142:431–7CrossRefGoogle ScholarPubMed
Bousquet, J, Schünemann, HJ, Togias, A, Bachert, C, Erhola, M, Hellings, PW et al. Next-generation allergic rhinitis and its impact on asthma (ARIA) guidelines for allergic rhinitis based on grading of recommendations assessment, development and evaluation (GRADE) and real-world evidence. J Allergy Clin Immunol 2020;145:70–80CrossRefGoogle ScholarPubMed
Wise, SK, Damask, C, Roland, LT, Ebert, C, Levy, JM, Lin, S et al. International consensus statement on allergy and rhinology: allergic rhinitis—2023. Int Forum Allergy Rhinol 2023;13:293–859CrossRefGoogle Scholar
Klimek, L, Sperl, A, Becker, S, Mösges, R, Tomazic, PV. Current therapeutical strategies for allergic rhinitis. Expert Opin Pharmacother 2019;20:83–9CrossRefGoogle ScholarPubMed
Balai, E, Gupta, KK, Jolly, K, Darr, A. Posterior nasal nerve neurectomy for the treatment of rhinitis: a systematic review and meta-analysis. Eur Ann Allergy Clin Immunol 2023;55:101–14CrossRefGoogle ScholarPubMed
Lin, HC, Lin, PW, Su, CY, Chang, HW. Radiofrequency for the treatment of allergic rhinitis refractory to medical therapy. Laryngoscope 2003;113:673-8CrossRefGoogle ScholarPubMed
Irawati, N, Bashiruddin, J, Rengganis, I, Lisnawati, L, Dharma, R, Harahap, A et al. The effect of early radiofrequency turbinate reduction, intranasal steroid, and antihistamine H-1 on persistent allergic rhinitis: a randomized clinical trial. Braz J Otorhinolaryngol 2023;89:235–43CrossRefGoogle ScholarPubMed
Neiderman NN, Carmel, Caspi, I, Eisenberg, N, Halevy, N, Wengier, A, Shpigel, I et al. Quality of life after radio frequency ablation turbinate reduction (RFATR) among patients with rhinitis medicamentosa & withdrawal from decongestant topical spray abuse. Am J Otolaryngol 2023;44:103842CrossRefGoogle Scholar
Page, MJ, McKenzie, JE, Bossuyt, PM, Boutron, I, Hoffmann, TC, Mulrow, CD et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021;372:n71CrossRefGoogle ScholarPubMed
Tricco, AC, Lillie, E, Zarin, W, O'Brien, KK, Colquhoun, H, Levac, D et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med 2018;169:467–73CrossRefGoogle ScholarPubMed
Higgins, JPT, Altman, DG, Gøtzsche, PC, Jüni, P, Moher, D, Oxman, AD et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011;343:d5928CrossRefGoogle ScholarPubMed
Yang, W, Chen, ZH, Yi, ZY, Huang, XD, Han, QM, Zhang, RH. Effectiveness of intra-articular injection of hyaluronic acid versus placebo in the treatment of early and mid-stage knee osteoarthritis: a Meta-analysis based on randomized, double-blind, controlled, clinical trials. Chin J Tissue Eng Res 2021;25:3760–6Google Scholar
Higgins, JPT, Thomas, J, Chandler, J, Cumpston, M, Li, T, Page, MJ et al., eds. Cochrane Handbook for Systematic Reviews of Interventions, 2nd Edn. Chichester, UK: John Wiley & Sons, 2019.CrossRefGoogle Scholar
Liu, DQ. Therapeutic efficacy of endoscopic radiofrequency in 58 cases of perennial allergic rhinitis. Shaanxi Med J 2006;35:87–8Google Scholar
Li, CH, Zhou, GY, Huang, ZH. Coblation plasma surgery system in the treatment of perennial allergic rhinitis. Chin Arch Otolaryngol Head Neck Surg 2009;16:586–9Google Scholar
Li, Y, Xie, JH. Therapeutic efficacy of BCG polysaccharide nucleic acid in conjunction with radiofrequency therapy for the management of allergic rhinitis. Int Med Health Guid News 2009;15:30–1Google Scholar
Xu, XH. Comparative study on the efficacy of pharmacological and surgical interventions in 98 cases of allergic rhinitis. China Clin Pract Med 2010;04:133–4Google Scholar
Zhao, J, Feng, QJ, Xin, X, Zhang, D, Yang, LX, Zhang, AJ. Efficacy analysis of nasal corticosteroid combined with low-temperature plasma radiofrequency ablation in the management of perennial allergic rhinitis. Chin J Clin Electron Ed 2012;6:1329–30Google Scholar
Zhan, CG, Hao, J, Song, W. Analysis of the clinical efficacy of surgical intervention in 53 cases of allergic rhinitis. Med Inf 2014;27:509–10Google Scholar
Wang, M. Clinical observation on treatment of budesonide allergic rhinitis with plasma. Chin J Front Med Sci (Elect Ver) 2014;6:132–4Google Scholar
Zeng, J. Analysis of the impact of nasal endoscopy-assisted treatment on allergic rhinitis. Contemp Med 2015;36:73–4Google Scholar
Feng, Q. Clinical efficacy analysis of low-temperature plasma ablation assisted by nasal endoscopy in the treatment of allergic rhinitis. Psychol Doct 2016;22:64–5Google Scholar
Du, JW, Liu, WX, Feng, J, Peng, T, Li, HG, Su, LS. Therapeutic effects investigation of physical therapy and pharmacotherapy in the treatment of persistent allergic rhinitis. J North Sichuan Med Coll 2016;31:820–3Google Scholar
Zeng, J. Treatment of allergic rhinitis with the assistance of nasal endoscopy. Contemp Med 2017;23:76–7Google Scholar
Liu, C. Observation on low temperature plasma ablation and drug treatment in moderate and severe allergic rhinitis. China Contin Med Educ 2018;10:100–2Google Scholar
Wang, RP. Clinical study of mometasone furoate nasal spray combined with low-temperature plasma radiofrequency ablation in the treatment of perennial allergic rhinitis. J Med Forum 2019;40:138–9Google Scholar
Ku, EZL. Analysis of the clinical efficacy of plasma radiofrequency ablation in the treatment of allergic rhinitis. Electron J Clin Med Lit 2020;7:81,85Google Scholar
Li, Y, Hu, HL, Xing, PM, Yue, W, Zhang, YG, Liang, CC et al. Efficacy of nasal endoscopic low-temperature plasma radiofrequency ablation combined with sodium cromoglicate, naphazoline hydrochloride and chlorphenamine maleate nasal spray in the treatment of perennial allergic rhinitis. China Med Pharm 2023;13:167–70Google Scholar
Chen, J, Wu, JB, Wu, K, Zheng, JR, Mei, LY, Mei, Y. Cumulative noise exposure and the risk of high-frequency hearing loss relationships [in Chinese]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi [Chin J Ind Hyg Occup Dis] 2021;39:919–24Google ScholarPubMed
Zhang, TS, Zhong, WZ. Performance of the nonparametric trim and fill method in stata. J Evid-Based Med 2009;9:240–2Google Scholar
Zhao, Z, Hu, SX, Guan, JF, Yi, JF, Zhang, ZW, Chen, FY et al. Systematic review and sequential analysis of Xuebijing Injection in treatment of systemic inflammatory response syndrome [in Chinese]. Zhongguo Zhong Yao Za Zhi [China J Chin Mater Med] 2021;46:3980–9Google ScholarPubMed
Hsu, DW, Suh, JD. Anatomy and physiology of nasal obstruction. Otolaryngol Clin North Am 2018;51:853–65CrossRefGoogle ScholarPubMed
Ciprandi, G, Cirillo, I, Klersy, C, Marseglia, GL, Caimmi, D, Vizzaccaro, A. Nasal obstruction is the key symptom in hay fever patients. Otolaryngol Head Neck Surg 2005;133:429–35CrossRefGoogle Scholar
Ciprandi, G, Tosca, MA. Turbinate hypertrophy, allergic rhinitis, and otitis media. Curr Allergy Asthma Rep 2021;21:40CrossRefGoogle ScholarPubMed
Türk, B, Korkut, AY, Kaya, KS, Salepçi, E, Ünsal, Ö, Coşkun, BU et al. Results of radiofrequency ablation of inferior turbinate hypertrophy in patients with allergic and non-allergic rhinitis. Sisli Etfal Hastan Tip Bul 2018;52:296–301Google ScholarPubMed
Lin, HC, Lin, PW, Friedman, M, Chang, HW, Su, YY, Chen, YJ et al. Long-term results of radiofrequency turbinoplasty for allergic rhinitis refractory to medical therapy. Arch Otolaryngol Head Neck Surg 2010;136:892–5CrossRefGoogle ScholarPubMed
Bernstein, JA. Nonallergic rhinitis: therapeutic options. Curr Opin Allergy Clin Immunol 2013;13:410–6CrossRefGoogle ScholarPubMed
Banov, CH, Lieberman, P. Vasomotor Rhinitis Study Groups. Efficacy of azelastine nasal spray in the treatment of vasomotor (perennial nonallergic) rhinitis. Ann Allergy Asthma Immunol 2001;86:28–35Google Scholar
Yang, SI, Lee, IH, Kim, M, Ryu, G, Kang, SY, Kim, MA et al. KAAACI allergic rhinitis guidelines: part 1. Update in pharmacotherapy. Allergy Asthma Immunol Res 2023;15:19–31CrossRefGoogle ScholarPubMed
Park, DY, Lee, YJ, Kim, DK, Kim, SW, Yang, HJ, Kim, DH et al. KAAACI Allergic rhinitis guidelines: part 2. Update in non-pharmacological management. Allergy Asthma Immunol Res 2023;15:145–59CrossRefGoogle ScholarPubMed
Huang, W, Zhang, LN, Fu, JT, Zhong, ZB. Clinical observation on curative effect of tongbi tuomin tang in treatment of persistent allergic rhinitis and impacts on serum IgE, IL-4 and IL-12. Chin J Tradit Med Sci Technol 2017;24:138–40Google Scholar